Cryo-EM structure of noradrenaline transporter in apo state
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8wtu
Q-score: 0.614
Hu T, Yu Z, Zhao J, Meng Y, Salomon K, Bai Q, Wei Y, Zhang J, Xu S, Dai Q, Yu R, Yang B, Loland CJ, Zhao Y
Nature (2024) 632 pp. 930-937 [ DOI: doi:10.1038/s41586-024-07638-z Pubmed: 39085602 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sodium-dependent noradrenaline transporter (63 kDa, Protein from Homo sapiens)
- Structure of a protein (63 MDa, Complex from Homo sapiens)
Cryo-EM structure of noradrenaline transporter in complex with noradrenaline
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8wtv
Q-score: 0.655
Hu T, Yu Z, Zhao J, Meng Y, Salomon K, Bai Q, Wei Y, Zhang J, Xu S, Dai Q, Yu R, Yang B, Loland CJ, Zhao Y
Nature (2024) 632 pp. 930-937 [ DOI: doi:10.1038/s41586-024-07638-z Pubmed: 39085602 ]
- Water (18 Da, Ligand)
- Sodium-dependent noradrenaline transporter (63 kDa, Protein from Homo sapiens)
- Noradrenaline (170 Da, Ligand)
- Structure of a protein (63 MDa, Complex from Homo sapiens)
- Sodium ion (22 Da, Ligand)
- Chloride ion (35 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of noradrenaline transporter in complex with a x-MrlA analogue
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8wtw
Q-score: 0.617
Hu T, Yu Z, Zhao J, Meng Y, Salomon K, Bai Q, Wei Y, Zhang J, Xu S, Dai Q, Yu R, Yang B, Loland CJ, Zhao Y
Nature (2024) 632 pp. 930-937 [ DOI: doi:10.1038/s41586-024-07638-z Pubmed: 39085602 ]
- Sodium-dependent noradrenaline transporter (63 kDa, Protein from Homo sapiens)
- Mrla (1 kDa, Protein from Conus marmoreus)
- Apo (Complex from Homo sapiens)
- Chloride ion (35 Da, Ligand)
- Sodium ion (22 Da, Ligand)
Cryo-EM structure of noradrenaline transporter in complex with bupropion
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8wtx
Q-score: 0.58
Hu T, Yu Z, Zhao J, Meng Y, Salomon K, Bai Q, Wei Y, Zhang J, Xu S, Dai Q, Yu R, Yang B, Loland CJ, Zhao Y
Nature (2024) 632 pp. 930-937 [ DOI: doi:10.1038/s41586-024-07638-z Pubmed: 39085602 ]
- (2~{r})-2-(~{tert}-butylamino)-1-(3-chlorophenyl)propan-1-one (239 Da, Ligand)
- Sodium-dependent noradrenaline transporter (63 kDa, Protein from Homo sapiens)
- Structure of a protein (63 MDa, Complex from Homo sapiens)
Cryo-EM structure of noradrenaline transporter in complex with ziprasidone
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8wty
Q-score: 0.549
Hu T, Yu Z, Zhao J, Meng Y, Salomon K, Bai Q, Wei Y, Zhang J, Xu S, Dai Q, Yu R, Yang B, Loland CJ, Zhao Y
Nature (2024) 632 pp. 930-937 [ DOI: doi:10.1038/s41586-024-07638-z Pubmed: 39085602 ]
- Ziprasidone (412 Da, Ligand)
- Sodium-dependent noradrenaline transporter (63 kDa, Protein from Homo sapiens)
- Structure of a protein (63 MDa, Complex from Homo sapiens)