Human pre 13S proteasome assembly intermediate
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8tm4
Q-score: 0.429
Zhang H, Zhou C, Mohammad Z, Zhao J
Nat Commun (2024) 15 pp. 8184-8184 [ Pubmed: 39294158 DOI: doi:10.1038/s41467-024-52513-0 ]
- Proteasome subunit beta type-3 (22 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-3 (28 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-5 (26 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-7 (27 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-2 (25 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-1 (29 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-2 (22 kDa, Protein from Homo sapiens)
- Proteasome assembly chaperone 2 (29 kDa, Protein from Homo sapiens)
- Proteasome assembly chaperone 1 (32 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-7 (30 kDa, Protein from Homo sapiens)
- Proteasome beta ring assembly intermediate (Complex from Homo sapiens)
- Proteasome maturation protein (15 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-4 (29 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-6 (27 kDa, Protein from Homo sapiens)
Human mixed 13S proteasome assembly intermediate
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8tm5
Q-score: 0.477
Zhang H, Zhou C, Mohammad Z, Zhao J
Nat Commun (2024) 15 pp. 8184-8184 [ Pubmed: 39294158 DOI: doi:10.1038/s41467-024-52513-0 ]
- Proteasome subunit beta type-3 (22 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-3 (28 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-5 (26 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-7 (27 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-2 (25 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-1 (29 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-2 (22 kDa, Protein from Homo sapiens)
- Proteasome assembly chaperone 2 (29 kDa, Protein from Homo sapiens)
- Proteasome assembly chaperone 1 (32 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-7 (30 kDa, Protein from Homo sapiens)
- Proteasome beta ring assembly intermediate (Complex from Homo sapiens)
- Proteasome maturation protein (15 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-4 (29 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-6 (27 kDa, Protein from Homo sapiens)
Human premature 20S proteasome assembly intermediate
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8tm6
Q-score: 0.552
Zhang H, Zhou C, Mohammad Z, Zhao J
Nat Commun (2024) 15 pp. 8184-8184 [ Pubmed: 39294158 DOI: doi:10.1038/s41467-024-52513-0 ]
- Proteasome subunit beta type-3 (22 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-1 (26 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-3 (28 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-5 (26 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-7 (27 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-4 (29 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-1 (29 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-2 (22 kDa, Protein from Homo sapiens)
- Proteasome assembly chaperone 2 (29 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-6 (25 kDa, Protein from Homo sapiens)
- Proteasome assembly chaperone 1 (32 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-7 (30 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-5 (28 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-2 (25 kDa, Protein from Homo sapiens)
- Proteasome maturation protein (15 kDa, Protein from Homo sapiens)
- Pre 20s proteasome complex (Complex from Homo sapiens)
- Proteasome subunit alpha type-4 (29 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-6 (27 kDa, Protein from Homo sapiens)
Structure of human constitutive 20S proteasome complexed with the inhibitor TDI-8304
Resolution: 2.04 Å
EM Method: Single-particle
Fitted PDBs: 8ud9
Q-score: 0.732
Hsu HC, Li D, Zhan W, Ye J, Liu YJ, Leung A, Qin J, Crespo B, Gamo FJ, Zhang H, Cui L, Roth A, Kirkman LA, Li H, Lin G
Nat Commun (2023) 14 pp. 8302-8302 [ Pubmed: 38097652 DOI: doi:10.1038/s41467-023-44077-2 ]
- Proteasome subunit beta type-3 (22 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-5 (22 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-3 (28 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-4 (24 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-5 (26 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-7 (27 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Proteasome subunit beta type-6 (21 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-7 (25 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-1 (29 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-2 (22 kDa, Protein from Homo sapiens)
- (7s,10s,13s)-n-cyclopentyl-10-[2-(morpholin-4-yl)ethyl]-9,12-dioxo-13-(2-oxopyrrolidin-1-yl)-2-oxa-8,11-diazabicyclo[13.3.1]nonadeca-1(19),15,17-triene-7-carboxamide (597 Da, Ligand)
- Proteasome subunit beta type-1 (23 kDa, Protein from Homo sapiens)
- Human 20s constitutive proteasome complexed with inhibitor tdi-8304 (700 kDa, Complex from Homo sapiens)
- Proteasome subunit alpha type-2 (25 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-4 (29 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-6 (27 kDa, Protein from Homo sapiens)
AK-42 inhibitor binding human ClC-2 TMD
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8gqu
Q-score: 0.377
Ma T, Wang L, Chai A, Liu C, Cui W, Yuan S, Wing Ngor Au S, Sun L, Zhang X, Zhang Z, Lu J, Gao Y, Wang P, Li Z, Liang Y, Vogel H, Wang YT, Wang D, Yan K, Zhang H
Nat Commun (2023) 14 pp. 3424-3424 [ Pubmed: 37296152 DOI: doi:10.1038/s41467-023-39218-6 ]
- Chloride channel protein 2 (98 kDa, Protein from Homo sapiens)
- Ak-42 inhibitor binding human clc-2 tmd 3.5a (180 MDa, Complex from Homo sapiens)
- 2-[[2,6-bis(chloranyl)-3-phenylmethoxy-phenyl]amino]pyridine-3-carboxylic acid (389 Da, Ligand)
TMD masked refine map of human ClC-2
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7xja
Q-score: 0.372
Ma T, Wang L, Chai A, Liu C, Cui W, Yuan S, Wing Ngor Au S, Sun L, Zhang X, Zhang Z, Lu J, Gao Y, Wang P, Li Z, Liang Y, Vogel H, Wang YT, Wang D, Yan K, Zhang H
Nat Commun (2023) 14 pp. 3424- [ DOI: doi:10.1038/s41467-023-39218-6 ]
- Full length human clc-2 homo dimer (180 MDa, Complex from Homo sapiens)
- Chloride channel protein 2 (98 kDa, Protein from Homo sapiens)
Full length human CLC-2 channel in apo state
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 7xf5
Q-score: 0.258
Ma T, Wang L, Chai A, Liu C, Cui W, Yuan S, Wing Ngor Au S, Sun L, Zhang X, Zhang Z, Lu J, Gao Y, Wang P, Li Z, Liang Y, Vogel H, Wang YT, Wang D, Yan K, Zhang H
Nat Commun (2023) 14 pp. 3424- [ DOI: doi:10.1038/s41467-023-39218-6 ]
- Full length human clc-2 homo dimer (180 MDa, Complex from Homo sapiens)
- Chloride channel protein 2 (98 kDa, Protein from Homo sapiens)
Follicle stimulating hormone receptor
Resolution: 6.0 Å
EM Method: Single-particle
Fitted PDBs: 8i2h
Q-score: 0.022
Human SARM1 bounded with NMN and Nanobody-C6, Conformation 1
Resolution: 3.74 Å
EM Method: Single-particle
Fitted PDBs: 8gni
Q-score: 0.413
Hou YN, Cai Y, Li WH, He WM, Zhao ZY, Zhu WJ, Wang Q, Mai X, Liu J, Lee HC, Stjepanovic G, Zhang H, Zhao YJ
Nat Commun (2022) 13 pp. 7898-7898 [ Pubmed: 36550129 DOI: doi:10.1038/s41467-022-35581-y ]
- Beta-nicotinamide ribose monophosphate (335 Da, Ligand)
- Nanobody-c6 (Complex from Vicugna pacos)
- Nanobody c6 (13 kDa, Protein from Vicugna pacos)
- Human sarm1 (Complex from Homo sapiens)
- Human sarm1 bounded with nmn and nanobody-c6, conformation 1 (Complex)
- Nad(+) hydrolase sarm1 (79 kDa, Protein from Homo sapiens)
Human SARM1 bounded with NMN and Nanobody-C6, Conformation 2
Resolution: 3.78 Å
EM Method: Single-particle
Fitted PDBs: 8gnj
Q-score: 0.44
Hou YN, Cai Y, Li WH, He WM, Zhao ZY, Zhu WJ, Wang Q, Mai X, Liu J, Lee HC, Stjepanovic G, Zhang H, Zhao YJ
Nat Commun (2022) 13 pp. 7898-7898 [ Pubmed: 36550129 DOI: doi:10.1038/s41467-022-35581-y ]
- Beta-nicotinamide ribose monophosphate (335 Da, Ligand)
- Nanobody-c6 (Complex from Vicugna pacos)
- Nanobody-c6 (13 kDa, Protein from Vicugna pacos)
- Human sarm1 bounded with nmn and nanobody-c6, conformation 2 (Complex)
- Sarm1 (Complex from Homo sapiens)
- Nad(+) hydrolase sarm1 (79 kDa, Protein from Homo sapiens)