96-nm repeat of axonemal doublet microtubules from bovine sperm
Leung MR, Sun C, Zeng J, Anderson JR, Niu Q, Huang W, Noteborn WEM, Brown A, Zeev-Ben-Mordehai T, Zhang R
To Be Published
- Piercer of microtubule wall 2 protein (13 kDa, Protein from Bos taurus)
- Actin, cytoplasmic 2 (41 kDa, Protein from Bos taurus)
- Cilia- and flagella-associated protein 276 (19 kDa, Protein from Bos taurus)
- Centrin-2 (19 kDa, Protein from Bos taurus)
- Cilia- and flagella-associated protein 107 (23 kDa, Protein from Bos taurus)
- Ef-hand calcium-binding domain-containing protein 3 (50 kDa, Protein from Bos taurus)
- Radial spoke head protein 9 homolog (528 kDa, Protein from Bos taurus)
- Tektin-3 (56 kDa, Protein from Bos taurus)
- T-complex protein 1 subunit beta (57 kDa, Protein from Bos taurus)
- Cilia and flagella associated protein 299 (26 kDa, Protein from Bos taurus)
- Radial spoke head protein 9 homolog (31 kDa, Protein from Bos taurus)
- Tubulin alpha-3 chain (49 kDa, Protein from Bos taurus)
- Cilia- and flagella-associated protein 53 (62 kDa, Protein from Bos taurus)
- Meiosis-specific nuclear structural protein 1 (60 kDa, Protein from Bos taurus)
- Coiled-coil domain-containing protein 63 (66 kDa, Protein from Bos taurus)
- Coiled-coil domain containing 37 (72 kDa, Protein from Bos taurus)
- Dynein regulatory complex subunit 3 (60 kDa, Protein from Bos taurus)
- Cilia- and flagella-associated protein 161 (36 kDa, Protein from Bos taurus)
- Dpy30 domain-containing protein 1 (20 kDa, Protein from Bos taurus)
- Dynein axonemal heavy chain 6 (476 kDa, Protein from Bos taurus)
- Dynein axonemal heavy chain 10 (521 kDa, Protein from Bos taurus)
- Cilia and flagella associated protein 73 (36 kDa, Protein from Bos taurus)
- Wd repeat domain 63 (103 kDa, Protein from Bos taurus)
- Leucine-rich repeat-containing protein 51 (22 kDa, Protein from Bos taurus)
- Cilia and flagella associated protein 58 (103 kDa, Protein from Bos taurus)
- Enkurin (30 kDa, Protein from Bos taurus)
- Tektin-1 (48 kDa, Protein from Bos taurus)
- Serine/threonine/tyrosine interacting like 1 (35 kDa, Protein from Bos taurus)
- Chromosome 20 c5orf49 homolog (16 kDa, Protein from Bos taurus)
- Dynein axonemal intermediate chain 3 (147 kDa, Protein from Bos taurus)
- Tetratricopeptide repeat protein 29 (54 kDa, Protein from Bos taurus)
- Cilia- and flagella-associated protein 43 (192 kDa, Protein from Bos taurus)
- Magnesium ion (24 Da, Ligand from Bos taurus)
- Cilia- and flagella-associated protein 263 (44 kDa, Protein from Bos taurus)
- Cilia- and flagella-associated protein 68 (20 kDa, Protein from Bos taurus)
- Dynein regulatory complex subunit 4 (56 kDa, Protein from Bos taurus)
- Ciliogenesis-associated ttc17-interacting protein (43 kDa, Protein from Bos taurus)
- Morn repeat-containing protein 5 (20 kDa, Protein from Bos taurus)
- Sperm acrosome associated 9 (25 kDa, Protein from Bos taurus)
- Tubulin beta-4b chain (49 kDa, Protein from Bos taurus)
- Ef-hand domain-containing family member c2 (85 kDa, Protein from Bos taurus)
- Cilia and flagella associated protein 44 (213 kDa, Protein from Bos taurus)
- Guanosine-5'-triphosphate (523 Da, Ligand from Bos taurus)
- Rib43a-like with coiled-coils protein 2 (44 kDa, Protein from Bos taurus)
- Outer dynein arm-docking complex subunit 3 (72 kDa, Protein from Bos taurus)
- Stabilizer of axonemal microtubules 3 (37 kDa, Protein from Bos taurus)
- Tektin-2 (49 kDa, Protein from Bos taurus)
- Chromosome 13 c20orf85 homolog (15 kDa, Protein from Bos taurus)
- Ef-hand domain-containing protein 1 (74 kDa, Protein from Bos taurus)
- Ef-hand calcium binding domain 10 (15 kDa, Protein from Bos taurus)
- Ciliary microtubule inner protein 3 (21 kDa, Protein from Bos taurus)
- Tektin-5 (56 kDa, Protein from Bos taurus)
- Ef-hand calcium binding domain 6 (172 kDa, Protein from Bos taurus)
- Testis expressed 47 (29 kDa, Protein from Bos taurus)
- Cilia and flagella associated protein 100 (93 kDa, Protein from Bos taurus)
- Outer dynein arm-docking complex subunit 4 (78 kDa, Protein from Bos taurus)
- Tubulin alpha-3 chain (52 kDa, Protein from Bos taurus)
- Nme/nm23 family member 5 (23 kDa, Protein from Bos taurus)
- Dynein regulatory complex protein 1 (84 kDa, Protein from Bos taurus)
- Dynein light chain roadblock-type 2 (10 kDa, Protein from Bos taurus)
- Morn repeat-containing protein 3 (27 kDa, Protein from Bos taurus)
- T-complex protein 1 subunit eta (59 kDa, Protein from Bos taurus)
- Coiled-coil domain containing 40 (129 kDa, Protein from Bos taurus)
- Adenylate kinase 8 (56 kDa, Protein from Bos taurus)
- Outer dense fiber of sperm tails 3 (27 kDa, Protein from Bos taurus)
- Dynein regulatory complex subunit 2 (58 kDa, Protein from Bos taurus)
- Testis expressed 49 (15 kDa, Protein from Bos taurus)
- Ciliary microtubule associated protein 1b (32 kDa, Protein from Bos taurus)
- Testis specific serine kinase 6 (30 kDa, Protein from Bos taurus)
- Camp-dependent protein kinase catalytic subunit alpha (40 kDa, Protein from Bos taurus)
- Cytochrome b5 domain-containing protein 1 (26 kDa, Protein from Bos taurus)
- Outer dynein arm-docking complex subunit 2 (116 kDa, Protein from Bos taurus)
- Probable inactive peptidyl-prolyl cis-trans isomerase-like 6 (34 kDa, Protein)
- Dynein axonemal heavy chain 1 (488 kDa, Protein from Bos taurus)
- T-complex protein 1 subunit zeta (58 kDa, Protein from Bos taurus)
- T-complex protein 1 subunit delta (58 kDa, Protein from Bos taurus)
- Regulator of g protein signaling 22 (146 kDa, Protein)
- Protein phosphatase 1 regulatory subunit 32 (47 kDa, Protein from Bos taurus)
- Dynein regulatory complex subunit 7 (103 kDa, Protein from Bos taurus)
- Radial spoke head protein 3 homolog (68 kDa, Protein from Bos taurus)
- Camp-dependent protein kinase type i-alpha regulatory subunit (42 kDa, Protein from Bos taurus)
- Cilia- and flagella-associated protein 45 (65 kDa, Protein from Bos taurus)
- Dynein light chain 1, cytoplasmic (10 kDa, Protein from Bos taurus)
- Adenylate kinase 7 (83 kDa, Protein from Bos taurus)
- Dynein axonemal heavy chain 7 (461 kDa, Protein from Bos taurus)
- Sperm microtubule inner protein 7 (49 kDa, Protein from Bos taurus)
- Dynein light chain tctex-type 1 (12 kDa, Protein from Bos taurus)
- Cilia- and flagella- associated protein 210 (65 kDa, Protein from Bos taurus)
- A-kinase anchoring protein 14 (172 kDa, Protein from Bos taurus)
- Upf0602 protein c4orf47 homolog (34 kDa, Protein from Bos taurus)
- Dynein axonemal heavy chain 17 (509 kDa, Protein from Bos taurus)
- Lrp2-binding protein (39 kDa, Protein from Bos taurus)
- Probable inactive peptidyl-prolyl cis-trans isomerase-like 6 (38 kDa, Protein from Bos taurus)
- Nucleoside diphosphate kinase 7 (42 kDa, Protein from Bos taurus)
- Atp6v1f neighbor (20 kDa, Protein from Bos taurus)
- Tepp protein (24 kDa, Protein from Bos taurus)
- Cilia- and flagella-associated protein 95 (26 kDa, Protein from Bos taurus)
- Dnaj (hsp40) related, subfamily b, member 13 (36 kDa, Protein from Bos taurus)
- Testis-expressed sequence 37 protein (20 kDa, Protein from Bos taurus)
- Cfap97 domain containing 1 (19 kDa, Protein from Bos taurus)
- Putative malate dehydrogenase 1b (467 kDa, Protein from Bos taurus)
- Sperm-associated microtubule inner protein 5 (53 kDa, Protein from Bos taurus)
- Spermatid-specific manchette-related protein 1 (35 kDa, Protein from Bos taurus)
- Cilia- and flagella-associated protein 20 (141 kDa, Protein from Bos taurus)
- T-complex protein 1 subunit gamma (60 kDa, Protein from Bos taurus)
- Coiled-coil domain-containing protein 39 (110 kDa, Protein from Bos taurus)
- Dual specificity phosphatase 21 (22 kDa, Protein from Bos taurus)
- Ropporin-1-like protein (24 kDa, Protein from Bos taurus)
- Testis-expressed protein 43 (15 kDa, Protein from Bos taurus)
- Tektin bundle interacting protein 1 (24 kDa, Protein from Bos taurus)
- Adenylate kinase 7 (134 kDa, Protein from Bos taurus)
- Leucine-rich repeat-containing protein 23 (39 kDa, Protein from Bos taurus)
- Axonemal dynein light intermediate polypeptide 1 (29 kDa, Protein from Bos taurus)
- Chromosome 19 c17orf98 homolog (17 kDa, Protein from Bos taurus)
- Iq motif containing with aaa domain 1 (96 kDa, Protein from Bos taurus)
- Sperm-associated antigen 8 (51 kDa, Protein from Bos taurus)
- Protein fam166c (23 kDa, Protein from Bos taurus)
- Theg spermatid protein like (50 kDa, Protein from Bos taurus)
- Dynein axonemal intermediate chain 1 (80 kDa, Protein from Bos taurus)
- Dynein axonemal intermediate chain 7 (83 kDa, Protein from Bos taurus)
- Leucine rich repeat containing 34 (49 kDa, Protein from Bos taurus)
- Radial spoke head 14 homolog (41 kDa, Protein from Bos taurus)
- Sperm associated microtubule inner protein 4 (67 kDa, Protein from Bos taurus)
- Cilia and flagella associated protein 251 (83 kDa, Protein from Bos taurus)
- Tektin-4 (52 kDa, Protein from Bos taurus)
- Dynein regulatory complex protein 9 (51 kDa, Protein from Bos taurus)
- Cilia- and flagella-associated protein 144 (16 kDa, Protein from Bos taurus)
- Cilia- and flagella-associated protein 276 (221 kDa, Protein from Bos taurus)
- T-complex protein 1 subunit theta (59 kDa, Protein from Bos taurus)
- T-complex protein 1 subunit alpha (60 kDa, Protein from Bos taurus)
- Dynein axonemal heavy chain 2 (508 kDa, Protein from Bos taurus)
- Dynein regulatory complex protein 10 (51 kDa, Protein from Bos taurus)
- Ankyrin repeat and ef-hand domain containing 1 (87 kDa, Protein from Bos taurus)
- Dynein axonemal heavy chain 12 (454 kDa, Protein from Bos taurus)
- Ccdc96 protein (63 kDa, Protein from Bos taurus)
- Cilia and flagella associated protein 77 (32 kDa, Protein from Bos taurus)
- Piercer of microtubule wall 1 protein (15 kDa, Protein from Bos taurus)
- Cilia- and flagella-associated protein 20 (22 kDa, Protein from Bos taurus)
- T-complex protein 1 subunit epsilon (59 kDa, Protein from Bos taurus)
- Protein flattop (21 kDa, Protein from Bos taurus)
- Wd repeat domain 64 (123 kDa, Protein from Bos taurus)
- 96-nm repeat of axonemal doublet microtubules from bovine sperm (Cellular component from Bos taurus)
- Calcium/calmodulin dependent protein kinase iv (49 kDa, Protein)
- Ciliary microtubule associated protein 1c (30 kDa, Protein from Bos taurus)
- Cilia and flagella associated protein 57 (541 kDa, Protein from Bos taurus)
- Dynein intermediate chain 2, axonemal isoform x2 (70 kDa, Protein from Bos taurus)
- Cilia- and flagella-associated protein 97 domain containing 1 (22 kDa, Protein from Bos taurus)
- Leucine rich repeats and death domain containing 1 (98 kDa, Protein from Bos taurus)
- Iq motif and ubiquitin domain containing (92 kDa, Protein from Bos taurus)
- Calmodulin 2 (16 kDa, Protein from Bos taurus)
- Guanosine-5'-diphosphate (443 Da, Ligand from Bos taurus)
- T-complex-associated-testis-expressed 1 (55 kDa, Protein from Bos taurus)
- Ef-hand domain-containing family member b (97 kDa, Protein from Bos taurus)
- Dynein light chain tctex-type protein 2b (17 kDa, Protein from Bos taurus)
- Cilia- and flagella-associated protein 52 (68 kDa, Protein from Bos taurus)
- Radial spoke head 6 homolog a (79 kDa, Protein from Bos taurus)
- Family with sequence similarity 166 member a (36 kDa, Protein from Bos taurus)
- Dynein axonemal heavy chain 2 (16 kDa, Protein from Bos taurus)
- Malate dehydrogenase, cytoplasmic (36 kDa, Protein from Bos taurus)
- Parkin coregulated gene protein (29 kDa, Protein from Bos taurus)
- Dynein axonemal heavy chain 6 (22 kDa, Protein from Bos taurus)
- Coiled-coil domain-containing protein 105 (57 kDa, Protein from Bos taurus)
- Calaxin (24 kDa, Protein from Bos taurus)
- Sperm surface protein sp17 (16 kDa, Protein from Bos taurus)
- Zinc finger mynd-type containing 12 (41 kDa, Protein from Bos taurus)
- Putative malate dehydrogenase 1b (58 kDa, Protein from Bos taurus)
- Cilia- and flagella-associated protein 91 (89 kDa, Protein from Bos taurus)
- Cilia- and flagella-associated protein 141 (12 kDa, Protein from Bos taurus)
- Testis expressed 33 (30 kDa, Protein from Bos taurus)
Cryo-EM structure of bovine Fallopian tube cilia doublet microtubule (48-nm periodicity)
Resolution: 3.52 Å
EM Method: Single-particle
Fitted PDBs: 9cpb
Q-score: 0.392
Leung MR, Sun C, Zeng J, Anderson JR, Niu Q, Huang W, Noteborn WEM, Brown A, Zeev-Ben-Mordehai T, Zhang R
Nature (2025) 637 pp. 1170-1177 [ DOI: doi:10.1038/s41586-024-08337-5 Pubmed: 39743588 ]
- Sperm acrosome associated 9 (19 kDa, Protein from Bos taurus)
- Pierce2 (13 kDa, Protein from Bos taurus)
- Tektin-2 (49 kDa, Protein from Bos taurus)
- Cilia and flagella associated protein 161 (36 kDa, Protein from Bos taurus)
- Cfap95 (26 kDa, Protein from Bos taurus)
- Coiled-coil domain containing 173 (65 kDa, Protein from Bos taurus)
- Sperm associated antigen 8 (51 kDa, Protein from Bos taurus)
- Cilia and flagella associated protein 52 (68 kDa, Protein from Bos taurus)
- Cfap141 (12 kDa, Protein from Bos taurus)
- Cilia and flagella associated protein 90 (16 kDa, Protein from Bos taurus)
- Ef-hand calcium-binding domain-containing protein 1 (24 kDa, Protein from Bos taurus)
- Nucleoside diphosphate kinase 7 (42 kDa, Protein from Bos taurus)
- Ef-hand calcium binding domain 6 (162 kDa, Protein from Bos taurus)
- Bovine fallopian tube cilia (Cellular component from Bos taurus)
- Tektin-3 (56 kDa, Protein from Bos taurus)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Meiosis-specific nuclear structural protein 1 (60 kDa, Protein from Bos taurus)
- Magnesium ion (24 Da, Ligand)
- Tubulin alpha-1d chain (50 kDa, Protein from Bos taurus)
- Cilia- and flagella-associated protein 20 (22 kDa, Protein from Bos taurus)
- Cilia and flagella associated protein 77 (32 kDa, Protein from Bos taurus)
- Pacrg protein (29 kDa, Protein from Bos taurus)
- Ttc25 protein (78 kDa, Protein from Bos taurus)
- Protein flattop (21 kDa, Protein from Bos taurus)
- Enkurin, trpc channel interacting protein (30 kDa, Protein from Bos taurus)
- Ciliary microtubule associated protein 1c (30 kDa, Protein from Bos taurus)
- Tektin-1 (48 kDa, Protein from Bos taurus)
- Cilia and flagella associated protein 45 (65 kDa, Protein from Bos taurus)
- Ciliary microtubule associated protein 1a (27 kDa, Protein from Bos taurus)
- Methyl-cpg binding domain protein 1 (62 kDa, Protein from Bos taurus)
- Coiled-coil domain containing 114 (77 kDa, Protein from Bos taurus)
- Outer dynein arm-docking complex subunit 3 (72 kDa, Protein from Bos taurus)
- Cilia-and flagella-associated protein 96 (34 kDa, Protein from Bos taurus)
- Pierce1 (15 kDa, Protein from Bos taurus)
- Uncharacterized protein c1orf158 homolog (23 kDa, Protein from Bos taurus)
- Efhc2 (85 kDa, Protein from Bos taurus)
- Cfap276 (19 kDa, Protein from Bos taurus)
- Tubulin beta-4b chain (49 kDa, Protein from Bos taurus)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Tektin-4 (52 kDa, Protein from Bos taurus)
- Armadillo repeat containing 4 (116 kDa, Protein from Bos taurus)
- Ef-hand domain containing 1 (74 kDa, Protein from Bos taurus)
- Ef-hand domain family member b (97 kDa, Protein from Bos taurus)
- Protein fam166b (30 kDa, Protein from Bos taurus)
- Rib43a-like with coiled-coils protein 2 (44 kDa, Protein from Bos taurus)
- Cilia- and flagella-associated protein 144 (16 kDa, Protein from Bos taurus)
Cryo-EM structure of porcine brain ventricles cilia doublet microtubule (48-nm periodicity)
Resolution: 3.65 Å
EM Method: Single-particle
Fitted PDBs: 9cpc
Q-score: 0.378
Leung MR, Sun C, Zeng J, Anderson JR, Niu Q, Huang W, Noteborn WEM, Brown A, Zeev-Ben-Mordehai T, Zhang R
Nature (2025) 637 pp. 1170-1177 [ DOI: doi:10.1038/s41586-024-08337-5 Pubmed: 39743588 ]
- Cilia and flagella associated protein 141 (12 kDa, Protein from Sus scrofa)
- Parkin coregulated (29 kDa, Protein from Sus scrofa)
- Cfap107/c1orf158 (23 kDa, Protein from Sus scrofa)
- Tektin (48 kDa, Protein from Sus scrofa)
- Chromosome 1 c9orf135 homolog (26 kDa, Protein from Sus scrofa)
- Cilia- and flagella-associated protein 53 (62 kDa, Protein from Sus scrofa)
- Ef-hand domain family member b (98 kDa, Protein from Sus scrofa)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Ciliary microtubule inner protein 2b (28 kDa, Protein from Sus scrofa)
- Outer dynein arm docking complex subunit 3 (72 kDa, Protein from Sus scrofa)
- Ef-hand calcium binding domain 1 (29 kDa, Protein from Sus scrofa)
- Cilia- and flagella-associated protein 52 (68 kDa, Protein from Sus scrofa)
- Tektin (52 kDa, Protein from Sus scrofa)
- Sperm acrosome associated 9 (25 kDa, Protein from Sus scrofa)
- Tubulin beta chain (49 kDa, Protein from Sus scrofa)
- Chromosome 1 c15orf65 homolog (13 kDa, Protein from Sus scrofa)
- Ef-hand domain-containing family member c2 (87 kDa, Protein from Sus scrofa)
- Ciliary microtubule inner protein 2b (30 kDa, Protein from Sus scrofa)
- Piercer of microtubule wall 1 (15 kDa, Protein from Sus scrofa)
- Sperm-associated antigen 8 isoform 1 (50 kDa, Protein from Sus scrofa)
- Cilia and flagella associated protein 77 (32 kDa, Protein from Sus scrofa)
- Cilia-and flagella-associated protein 96 (34 kDa, Protein from Sus scrofa)
- Efcab6 (167 kDa, Protein from Sus scrofa)
- Outer dynein arm-docking complex subunit 4 (78 kDa, Protein from Sus scrofa)
- Enkurin (29 kDa, Protein from Sus scrofa)
- Protein flattop (19 kDa, Protein from Sus scrofa)
- Guanosine-5'-triphosphate (523 Da, Ligand from Sus scrofa)
- Nucleoside diphosphate kinase homolog 7 (42 kDa, Protein from Sus scrofa)
- Tubulin alpha chain (49 kDa, Protein from Sus scrofa)
- Cilia- and flagella-associated protein 20 (22 kDa, Protein from Sus scrofa)
- Coiled-coil domain-containing protein 114 isoform x2 (80 kDa, Protein from Sus scrofa)
- Rib43a domain with coiled-coils 2 (45 kDa, Protein from Sus scrofa)
- Cilia and flagella associated protein 210 (66 kDa, Protein from Sus scrofa)
- Tektin (56 kDa, Protein from Sus scrofa)
- Cilia and flagella associated protein 161 (35 kDa, Protein from Sus scrofa)
- Ef-hand domain containing 1 (74 kDa, Protein from Sus scrofa)
- Tektin (49 kDa, Protein from Sus scrofa)
- Armadillo repeat-containing protein 4 isoform 1 (116 kDa, Protein from Sus scrofa)
- Meiosis-specific nuclear structural protein 1 (60 kDa, Protein from Sus scrofa)
- Cilia from porcine brain ventricles (Cellular component from Sus scrofa)
- Rib43a-like with coiled-coils protein 1 (44 kDa, Protein from Sus scrofa)
- Cilia and flagella associated protein 276 (19 kDa, Protein from Sus scrofa)
- Cilia and flagella associated protein 144 (16 kDa, Protein from Sus scrofa)
- Cilia- and flagella-associated protein 45 (65 kDa, Protein from Sus scrofa)
Cryo-EM structure of histamine H3 receptor in complex with immethridine and miniGo
Resolution: 2.77 Å
EM Method: Single-particle
Fitted PDBs: 8yn7
Q-score: 0.548
Zhang X, Liu G, Zhong YN, Zhang R, Yang CC, Niu C, Pu X, Sun J, Zhang T, Yang L, Zhang C, Li X, Shen X, Xiao P, Sun JP, Gong W
Nat Commun (2024) 15 pp. 8296-8296 [ Pubmed: 39333117 DOI: doi:10.1038/s41467-024-52585-y ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Antibody fragment scfv16 (27 kDa, Protein from synthetic construct)
- 4-(1h-imidazol-4-ylmethyl)pyridine (159 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Engineered guanine nucleotide-binding protein g(o) subunit alpha,guanine nucleotide-binding protein g(o) subunit alpha (25 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Histamine h3 receptor (72 kDa, Protein from Homo sapiens)
- Immethridine-h3r-minigo-scfv16 complex (Complex from Homo sapiens)
Cryo-EM structure of histamine H3 receptor in complex with proxyfan and miniGo
Resolution: 2.77 Å
EM Method: Single-particle
Fitted PDBs: 8yn8
Q-score: 0.544
Zhang X, Liu G, Zhong YN, Zhang R, Yang CC, Niu C, Pu X, Sun J, Zhang T, Yang L, Zhang C, Li X, Shen X, Xiao P, Sun JP, Gong W
Nat Commun (2024) 15 pp. 8296-8296 [ Pubmed: 39333117 DOI: doi:10.1038/s41467-024-52585-y ]
- Engineered guanine nucleotide-binding protein g(o) subunit alpha,guanine nucleotide-binding protein g(o) subunit alpha (25 kDa, Protein from Homo sapiens)
- Antibody fragment scfv16 (27 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Proxyfan-h3r-minigo-scfv16 complex (Complex from Homo sapiens)
- 5-(3-phenylmethoxypropyl)-1h-imidazole (216 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Histamine h3 receptor (72 kDa, Protein from Homo sapiens)
Cryo-EM structure of histamine H1 receptor in complex with histamine and miniGq
Resolution: 2.66 Å
EM Method: Single-particle
Fitted PDBs: 8yn2
Q-score: 0.578
Zhang X, Liu G, Zhong YN, Zhang R, Yang CC, Niu C, Pu X, Sun J, Zhang T, Yang L, Zhang C, Li X, Shen X, Xiao P, Sun JP, Gong W
Nat Commun (2024) 15 pp. 8296-8296 [ Pubmed: 39333117 DOI: doi:10.1038/s41467-024-52585-y ]
- Antibody fragment scfv16 (27 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Histamine h1 receptor (80 kDa, Protein from Homo sapiens)
- Histamine-h1r-minigq-scfv16 complex (Complex from Homo sapiens)
- Histamine (111 Da, Ligand)
- Engineered guanine nucleotide-binding protein g(q) subunit alpha (28 kDa, Protein from synthetic construct)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
Cryo-EM structure of histamine H2 receptor in complex with histamine and miniGs
Resolution: 2.56 Å
EM Method: Single-particle
Fitted PDBs: 8yn3
Q-score: 0.623
Zhang X, Liu G, Zhong YN, Zhang R, Yang CC, Niu C, Pu X, Sun J, Zhang T, Yang L, Zhang C, Li X, Shen X, Xiao P, Sun JP, Gong W
Nat Commun (2024) 15 pp. 8296-8296 [ Pubmed: 39333117 DOI: doi:10.1038/s41467-024-52585-y ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Nanobody nb35 (15 kDa, Protein from synthetic construct)
- Histamine-h2r-minigs-nb35 complex (Complex from Homo sapiens)
- Histamine h2 receptor (62 kDa, Protein from Homo sapiens)
- Histamine (111 Da, Ligand)
- Engineered guanine nucleotide,binding protein g(s) subunit alpha (29 kDa, Protein from synthetic construct)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
Cryo-EM structure of histamine H2 receptor in complex with histamine and miniGq
Resolution: 2.97 Å
EM Method: Single-particle
Fitted PDBs: 8yn4
Q-score: 0.515
Zhang X, Liu G, Zhong YN, Zhang R, Yang CC, Niu C, Pu X, Sun J, Zhang T, Yang L, Zhang C, Li X, Shen X, Xiao P, Sun JP, Gong W
Nat Commun (2024) 15 pp. 8296-8296 [ Pubmed: 39333117 DOI: doi:10.1038/s41467-024-52585-y ]
- Histamine-h2r-minigq-scfv16 complex (Complex from Homo sapiens)
- Antibody fragment scfv16 (27 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Histamine h2 receptor (62 kDa, Protein from Homo sapiens)
- Histamine (111 Da, Ligand)
- Engineered guanine nucleotide-binding protein g(q) subunit alpha (28 kDa, Protein from synthetic construct)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
Cryo-EM structure of histamine H3 receptor in complex with histamine and Gi
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8yn5
Q-score: 0.589
Zhang X, Liu G, Zhong YN, Zhang R, Yang CC, Niu C, Pu X, Sun J, Zhang T, Yang L, Zhang C, Li X, Shen X, Xiao P, Sun JP, Gong W
Nat Commun (2024) 15 pp. 8296-8296 [ Pubmed: 39333117 DOI: doi:10.1038/s41467-024-52585-y ]
- Histamine-h3r-gi-scfv16 complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Antibody fragment scfv16 (27 kDa, Protein from synthetic construct)
- Histamine (111 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Histamine h3 receptor (72 kDa, Protein from Homo sapiens)
Cryo-EM structure of histamine H3 receptor in complex with imetit and Gi
Resolution: 2.77 Å
EM Method: Single-particle
Fitted PDBs: 8yn6
Q-score: 0.546
Zhang X, Liu G, Zhong YN, Zhang R, Yang CC, Niu C, Pu X, Sun J, Zhang T, Yang L, Zhang C, Li X, Shen X, Xiao P, Sun JP, Gong W
Nat Commun (2024) 15 pp. 8296-8296 [ Pubmed: 39333117 DOI: doi:10.1038/s41467-024-52585-y ]
- Antibody fragment scfv16 (27 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Histamine h3 receptor (72 kDa, Protein from Homo sapiens)
- Imetit-h3r-gi-scfv16 complex (Complex from Homo sapiens)
- 2-(1~{h}-imidazol-5-yl)ethyl carbamimidothioate (170 Da, Ligand)