SARS-CoV-2 RBD + IMCAS-123 + IMCAS-72 Fab
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 8xse
Q-score: 0.531
Tong Z, Tong J, Lei W, Xie Y, Cui Y, Jia G, Li S, Zhang Z, Cheng Z, Xing X, Ma H, Deng L, Zhang R, Zhao X, Liu K, Wang Q, Qi J, Huang H, Song R, Su Z, Wu G, Lou J, Gao GF
Cell Rep (2024) 43 pp. 114338-114338 [ Pubmed: 38850530 DOI: doi:10.1016/j.celrep.2024.114338 ]
- Spike protein s1 (23 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Imcas-123 l chain (23 kDa, Protein from Homo sapiens)
- Imcas-72 l chain (23 kDa, Protein from Homo sapiens)
- Imcas-123 h chain (23 kDa, Protein from Homo sapiens)
- Imcas-72 h chain (24 kDa, Protein from Homo sapiens)
- Cryo-em structure of sars-cov-2 rbd + imcas-123 + imcas-72 fab (Complex)
- Sars-cov-2 rbd (Complex from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Imcas-123 + imcas-72 fab (Complex from Homo sapiens)
SARS-CoV-2 RBD + IMCAS-364 + hACE2
Resolution: 2.16 Å
EM Method: Single-particle
Fitted PDBs: 8xsf
Q-score: 0.416
Tong Z, Tong J, Lei W, Xie Y, Cui Y, Jia G, Li S, Zhang Z, Cheng Z, Xing X, Ma H, Deng L, Zhang R, Zhao X, Liu K, Wang Q, Qi J, Huang H, Song R, Su Z, Wu G, Lou J, Gao GF
Cell Rep (2024) 43 pp. 114338-114338 [ Pubmed: 38850530 DOI: doi:10.1016/j.celrep.2024.114338 ]
- Ace2 (Complex from Homo sapiens)
- Spike protein s1 (23 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Imcas-364 h chain (50 kDa, Protein from Homo sapiens)
- Imcas-364 (Complex from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Cryo-em structure of sars-cov-2 rbd + imcas-364 + hace2 (global refinement) (Complex)
- Sars-cov-2 rbd (Complex from Severe acute respiratory syndrome coronavirus 2)
- Imcas-364 l chain (23 kDa, Protein from Homo sapiens)
- Angiotensin-converting enzyme 2 (92 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
SARS-CoV-2 RBD + IMCAS-364 (Local Refinement)
Resolution: 2.1 Å
EM Method: Single-particle
Fitted PDBs: 8xsi
Q-score: 0.555
Tong Z, Tong J, Lei W, Xie Y, Cui Y, Jia G, Li S, Zhang Z, Cheng Z, Xing X, Ma H, Deng L, Zhang R, Zhao X, Liu K, Wang Q, Qi J, Huang H, Song R, Su Z, Wu G, Lou J, Gao GF
Cell Rep (2024) 43 pp. 114338-114338 [ Pubmed: 38850530 DOI: doi:10.1016/j.celrep.2024.114338 ]
- Cryo-em structure of sars-cov-2 rbd + imcas-364 (local refinement) (Complex)
- Spike protein s1 (23 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Imcas-364 h chain (50 kDa, Protein from Homo sapiens)
- Imcas-364 (Complex from Homo sapiens)
- Sars-cov-2 rbd (Complex from Severe acute respiratory syndrome coronavirus 2)
- Imcas-364 l chain (23 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
SARS-CoV-2 Omicron BA.4 RBD + IMCAS-316 + ACE2
Resolution: 2.61 Å
EM Method: Single-particle
Fitted PDBs: 8xsj
Q-score: 0.453
Tong Z, Tong J, Lei W, Xie Y, Cui Y, Jia G, Li S, Zhang Z, Cheng Z, Xing X, Ma H, Deng L, Zhang R, Zhao X, Liu K, Wang Q, Qi J, Huang H, Song R, Su Z, Wu G, Lou J, Gao GF
Cell Rep (2024) 43 pp. 114338-114338 [ Pubmed: 38850530 DOI: doi:10.1016/j.celrep.2024.114338 ]
- Imcas-316 h chain (24 kDa, Protein from Homo sapiens)
- Imcas-316 l chain (23 kDa, Protein from Homo sapiens)
- Spike protein s1 (25 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Zinc ion (65 Da, Ligand)
- Cryo-em structure of sars-cov-2 omicron ba.4 rbd + imcas-316 + ace2 (Complex from Severe acute respiratory syndrome coronavirus 2)
- Angiotensin-converting enzyme 2 (92 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8xsl
Q-score: 0.359
Tong Z, Tong J, Lei W, Xie Y, Cui Y, Jia G, Li S, Zhang Z, Cheng Z, Xing X, Ma H, Deng L, Zhang R, Zhao X, Liu K, Wang Q, Qi J, Huang H, Song R, Su Z, Wu G, Lou J, Gao GF
Cell Rep (2024) 43 pp. 114338-114338 [ Pubmed: 38850530 DOI: doi:10.1016/j.celrep.2024.114338 ]
- Cryo-em structure of sars-cov-2 spike + imcas-123 (Complex from Severe acute respiratory syndrome coronavirus 2)
- Imcas-123 heavy chain (23 kDa, Protein from Homo sapiens)
- Imcas-123 light chain (23 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Spike glycoprotein (141 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
Cryo-EM structure of the 123-316 scDb/PT-RBD complex
Resolution: 2.86 Å
EM Method: Single-particle
Fitted PDBs: 8y0y
Q-score: 0.533
Tong Z, Tong J, Lei W, Xie Y, Cui Y, Jia G, Li S, Zhang Z, Cheng Z, Xing X, Ma H, Deng L, Zhang R, Zhao X, Liu K, Wang Q, Qi J, Huang H, Song R, Su Z, Wu G, Lou J, Gao GF
Cell Rep (2024) 43 pp. 114338-114338 [ Pubmed: 38850530 DOI: doi:10.1016/j.celrep.2024.114338 ]
- Spike glycoprotein (23 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- The 123-316 scdb/pt-rbd complex (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 123-316 scdb (56 kDa, Protein from Homo sapiens)
Cloprosetnol bound Prostaglandin F2-alpha receptor-Gq Protein Complex
Resolution: 2.63 Å
EM Method: Single-particle
Fitted PDBs: 8xjk
Q-score: 0.588
Li X, Zhang X, Wen X, Zhang D, Qu C, Miao X, Zhang W, Zhang R, Liu G, Xiao P, Sun JP, Gong W
Cell Rep (2024) 43 pp. 113893-113893 [ Pubmed: 38446662 DOI: doi:10.1016/j.celrep.2024.113893 ]
- Antibody fragment scfv16 (27 kDa, Protein from synthetic construct)
- Cloprosetnol-fp-minigq-scfv16 complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Engineered minigq (28 kDa, Protein from synthetic construct)
- Cloprostenol (424 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Fusion tag,prostaglandin f2-alpha receptor,lgbit (64 kDa, Protein from synthetic construct)
PGF2-alpha bound Prostaglandin F2-alpha receptor-Gq Protein Complex
Resolution: 2.77 Å
EM Method: Single-particle
Fitted PDBs: 8xjl
Q-score: 0.559
Li X, Zhang X, Wen X, Zhang D, Qu C, Miao X, Zhang W, Zhang R, Liu G, Xiao P, Sun JP, Gong W
Cell Rep (2024) 43 pp. 113893-113893 [ Pubmed: 38446662 DOI: doi:10.1016/j.celrep.2024.113893 ]
- Antibody fragment scfv16 (27 kDa, Protein from synthetic construct)
- Pgf2-alpha-fp-minigq-scfv16 complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Engineered minigq (28 kDa, Protein from synthetic construct)
- (z)-7-[(1r,2r,3r,5s)-3,5-bis(oxidanyl)-2-[(e,3s)-3-oxidanyloct-1-enyl]cyclopentyl]hept-5-enoic acid (354 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Fusion tag,prostaglandin f2-alpha receptor,lgbit (64 kDa, Protein from synthetic construct)
Latanoprost acid bound Prostaglandin F2-alpha receptor-Gq Protein Complex
Resolution: 2.85 Å
EM Method: Single-particle
Fitted PDBs: 8xjm
Q-score: 0.555
Li X, Zhang X, Wen X, Zhang D, Qu C, Miao X, Zhang W, Zhang R, Liu G, Xiao P, Sun JP, Gong W
Cell Rep (2024) 43 pp. 113893-113893 [ Pubmed: 38446662 DOI: doi:10.1016/j.celrep.2024.113893 ]
- Z-7-[(1r,2r,3r,5s)-3,5-bis(oxidanyl)-2-[(3r)-3-oxidanyl-5-phenyl-pentyl]cyclopentyl]hept-5-enoic acid (390 Da, Ligand)
- Antibody fragment scfv16 (27 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Engineered minigq (28 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Fusion tag,prostaglandin f2-alpha receptor,lgbit (64 kDa, Protein from synthetic construct)
- Latanoprost acid-fp-minigq-scfv16 complex (Complex from Homo sapiens)
Cloprosetnol bound Thromboxane A2 receptor-Gq Protein Complex
Resolution: 3.06 Å
EM Method: Single-particle
Fitted PDBs: 8xjn
Q-score: 0.509
Li X, Zhang X, Wen X, Zhang D, Qu C, Miao X, Zhang W, Zhang R, Liu G, Xiao P, Sun JP, Gong W
Cell Rep (2024) 43 pp. 113893-113893 [ Pubmed: 38446662 DOI: doi:10.1016/j.celrep.2024.113893 ]
- Antibody fragment scfv16 (27 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Cloprosetnol-tp-minigq-scfv16 complex (Complex from Homo sapiens)
- Engineered minigq (28 kDa, Protein from synthetic construct)
- Fusion tag,thromboxane a2 receptor,lgbit (61 kDa, Protein from synthetic construct)
- Cloprostenol (424 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)