Cryo-EM structure of USP1-UAF1-Ubiquitin in complex with TNG348
Simoneau A, Pratt CB, Wu HJ, Rajeswaran SS, Comer CG, Sudsakorn S, Zhang W, Liu S, Meier SR, Choi AH, Khendu T, Stowe H, Shen B, Whittington DA, Chen Y, Yu Y, Mallender WD, Feng T, Andersen JN, Maxwell JP, Throner S
Mol.Cancer Ther. (2025) [ DOI: doi:10.1158/1535-7163.MCT-24-0515 Pubmed: 39886906 ]
- Wd repeat-containing protein 48 (77 kDa, Protein from Homo sapiens)
- Usp1-uaf1-ub complex with tng348 (174 kDa, Complex from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- 2-(4-cyclopropyl-6-methoxypyrimidin-5-yl)-9-({4-[1-methyl-4-(trifluoromethyl)-1h-imidazol-2-yl]phenyl}methyl)-7-(2,2,2-trifluoroethyl)-7,9-dihydro-8h-purin-8-imine (603 Da, Ligand)
- 3-(methanesulfonyl)propan-1-amine (137 Da, Ligand)
- Ubiquitin (8 kDa, Protein from Homo sapiens)
- Ubiquitin carboxyl-terminal hydrolase 1 (88 kDa, Protein from Homo sapiens)
Resolution: 2.91 Å
EM Method: Single-particle
Fitted PDBs: 9jmz
Q-score: 0.489
Song H, Hao T, Han P, Wang H, Zhang X, Li X, Wang Y, Chen J, Li Y, Jin X, Duan X, Zhang W, Bi Y, Jin R, Sun L, Wang N, Gao GF
Cell (2025) [ Pubmed: 39848246 DOI: doi:10.1016/j.cell.2025.01.019 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Human-infecting bovine influenza h5n1 hemagglutinin complexed with avian receptor analog lsta (Complex from Influenza A virus (A/Indonesia/5/2005(H5N1)))
- N-acetyl-alpha-neuraminic acid (309 Da, Ligand)
- Hemagglutinin (57 kDa, Protein from Influenza A virus (A/Indonesia/5/2005(H5N1)))
Resolution: 2.84 Å
EM Method: Single-particle
Fitted PDBs: 9jn0
Q-score: 0.518
Cryo-EM structure of human VMAT2 in complex with serotonin.
Resolution: 2.98 Å
EM Method: Single-particle
Fitted PDBs: 8x3k
Q-score: 0.553
Wei F, Liu H, Zhang W, Wang J, Zhang Y
Nat Commun (2025) 16 pp. 323-323 [ DOI: doi:10.1038/s41467-024-55361-0 Pubmed: 39747030 ]
- Soluble cytochrome b562,synaptic vesicular amine transporter (69 kDa, Protein from Homo sapiens)
- Serotonin (176 Da, Ligand)
- Vmat2 (Complex from Homo sapiens)
CryoEM structure of human XPR1 in complex with phosphate in state A
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 9j51
Q-score: 0.468
Zhang W, Chen Y, Guan Z, Wang Y, Tang M, Du Z, Zhang J, Cheng M, Zuo J, Liu Y, Wang Q, Liu Y, Zhang D, Yin P, Ma L, Liu Z
Nat Commun (2025) 16 pp. 18-18 [ Pubmed: 39747008 DOI: doi:10.1038/s41467-024-55471-9 ]
- Solute carrier family 53 member 1 (84 kDa, Protein from Homo sapiens)
- Human xpr1 (Complex from Homo sapiens)
- Phosphate ion (94 Da, Ligand)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
CryoEM structure of human XPR1 in complex with phosphate in state B
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 9j52
Q-score: 0.468
Zhang W, Chen Y, Guan Z, Wang Y, Tang M, Du Z, Zhang J, Cheng M, Zuo J, Liu Y, Wang Q, Liu Y, Zhang D, Yin P, Ma L, Liu Z
Nat Commun (2025) 16 pp. 18-18 [ Pubmed: 39747008 DOI: doi:10.1038/s41467-024-55471-9 ]
- Solute carrier family 53 member 1 (84 kDa, Protein from Homo sapiens)
- Phosphate ion (94 Da, Ligand)
- Human xpr1 (Complex from Homo sapiens)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
CryoEM structure of human XPR1 in complex with phosphate in state C
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 9j53
Q-score: 0.413
Zhang W, Chen Y, Guan Z, Wang Y, Tang M, Du Z, Zhang J, Cheng M, Zuo J, Liu Y, Wang Q, Liu Y, Zhang D, Yin P, Ma L, Liu Z
Nat Commun (2025) 16 pp. 18-18 [ Pubmed: 39747008 DOI: doi:10.1038/s41467-024-55471-9 ]
- Solute carrier family 53 member 1 (84 kDa, Protein from Homo sapiens)
- Phosphate ion (94 Da, Ligand)
- Human xpr1 (Complex from Homo sapiens)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
Cryo-EM structure of human VMAT2 in complex with valbenazine
Resolution: 3.38 Å
EM Method: Single-particle
Fitted PDBs: 9kq8
Q-score: 0.495
Wei F, Liu H, Zhang W, Wang J, Zhang Y
Nat Commun (2025) 16 pp. 323-323 [ DOI: doi:10.1038/s41467-024-55361-0 Pubmed: 39747030 ]
- Soluble cytochrome b562,synaptic vesicular amine transporter (69 kDa, Protein from Homo sapiens)
- Valbenazine (418 Da, Ligand)
- Vmat2 (Complex from Homo sapiens)
Cryo-EM structure of human VMAT2 in complex with Tetrabenazine
Resolution: 3.28 Å
EM Method: Single-particle
Fitted PDBs: 9kqa
Q-score: 0.462
Cryo-EM structure of human VMAT2 in complex with dopamine.
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 9kqe
Q-score: 0.516
Wei F, Liu H, Zhang W, Wang J, Zhang Y
Nat Commun (2025) 16 pp. 323-323 [ DOI: doi:10.1038/s41467-024-55361-0 Pubmed: 39747030 ]
- L-dopamine (153 Da, Ligand)
- Soluble cytochrome b562,synaptic vesicular amine transporter (69 kDa, Protein from Homo sapiens)
- Vmat2 (Complex from Homo sapiens)