Structure of 1:1 PAPP-A.ProMBP complex(half map)
Resolution: 3.45 Å
EM Method: Single-particle
Fitted PDBs: 7y5n
Q-score: 0.476
Zhong Q, Chu H, Wang G, Zhang C, Li R, Guo F, Meng X, Lei X, Zhou Y, Ren R, Tao L, Li N, Gao N, Wei Y, Qiao J, Hang J
Cell Discov (2022) 8 pp. 137-137 [ Pubmed: 36550107 DOI: doi:10.1038/s41421-022-00502-2 ]
- Bone marrow proteoglycan (25 kDa, Protein from Homo sapiens)
- Structure of 1:1 papp-a/prombp complex(half map) (Complex from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Pappalysin-1 (172 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Structure of 1:1 PAPP-A.STC2 complex(half map)
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 7y5q
Q-score: 0.438
Zhong Q, Chu H, Wang G, Zhang C, Li R, Guo F, Meng X, Lei X, Zhou Y, Ren R, Tao L, Li N, Gao N, Wei Y, Qiao J, Hang J
Cell Discov (2022) 8 pp. 137-137 [ Pubmed: 36550107 DOI: doi:10.1038/s41421-022-00502-2 ]
- Zinc ion (65 Da, Ligand)
- Structure of 1:1 papp-a/stc2 complex(half map) (Complex from Homo sapiens)
- Stanniocalcin-2 (33 kDa, Protein from Homo sapiens)
- Maltose/maltodextrin-binding periplasmic protein,pappalysin-1 (216 kDa, Protein from Homo sapiens)
Structure of 2:2 PAPP-A.ProMBP comple
Resolution: 3.64 Å
EM Method: Single-particle
Fitted PDBs: 8hgg
Q-score: 0.408
Zhong Q, Chu H, Wang G, Zhang C, Li R, Guo F, Meng X, Lei X, Zhou Y, Ren R, Tao L, Li N, Gao N, Wei Y, Qiao J, Hang J
Cell Discov (2022) 8 pp. 137-137 [ Pubmed: 36550107 DOI: doi:10.1038/s41421-022-00502-2 ]
- Bone marrow proteoglycan (25 kDa, Protein from Homo sapiens)
- Pappalysin-1 (181 kDa, Protein from Homo sapiens)
- Structure of 2:2 papp-a/prombp complex (Complex from Homo sapiens)
- Zinc ion (65 Da, Ligand)
Structure of 2:2 PAPP-A.STC2 complex
Resolution: 4.16 Å
EM Method: Single-particle
Fitted PDBs: 8hgh
Q-score: 0.295
Zhong Q, Chu H, Wang G, Zhang C, Li R, Guo F, Meng X, Lei X, Zhou Y, Ren R, Tao L, Li N, Gao N, Wei Y, Qiao J, Hang J
Cell Discov (2022) 8 pp. 137-137 [ Pubmed: 36550107 DOI: doi:10.1038/s41421-022-00502-2 ]
- Structure of 2:2 papp-a/stc2 complex (Complex from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Stanniocalcin-2 (33 kDa, Protein from Homo sapiens)
- Maltose/maltodextrin-binding periplasmic protein,pappalysin-1 (216 kDa, Protein from Homo sapiens)
Structure of Thyrotropin-Releasing Hormone Receptor bound with Taltirelin.
Resolution: 3.26 Å
EM Method: Single-particle
Fitted PDBs: 7x1t
Q-score: 0.462
Yang F, Zhang H, Meng X, Li Y, Zhou Y, Ling S, Sun D, Lv P, Liu L, Shi P, Tian C
Cell Res (2022) 32 pp. 858-861 [ Pubmed: 35352031 DOI: doi:10.1038/s41422-022-00646-6 ]
- Thyrotropin-releasing hormone receptor (45 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Taltirelin (423 Da, Protein from synthetic construct)
- Mini-g alpha q protein (28 kDa, Protein from Homo sapiens)
- The thyrotropin-releasing hormone receptor and gq heterotrimer complex (Complex from Homo sapiens)
- Scfv16 (26 kDa, Protein from Rattus norvegicus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Bos taurus)
Structure of Thyrotropin-Releasing Hormone Receptor bound with an Endogenous Peptide Agonist TRH.
Resolution: 3.19 Å
EM Method: Single-particle
Fitted PDBs: 7x1u
Q-score: 0.445
Yang F, Zhang H, Meng X, Li Y, Zhou Y, Ling S, Sun D, Lv P, Liu L, Shi P, Tian C
Cell Res (2022) 32 pp. 858-861 [ Pubmed: 35352031 DOI: doi:10.1038/s41422-022-00646-6 ]
- Thyrotropin-releasing hormone receptor (45 kDa, Protein from Homo sapiens)
- Endogenous peptide agonist trh (362 Da, Protein from synthetic construct)
- Mini-g alpha q prtoein (28 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- The thyrotropin-releasing hormone receptor and gq heterotrimer complex (Complex from Homo sapiens)
- Scfv16 (26 kDa, Protein from Rattus norvegicus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Bos taurus)
Structure of somatostatin receptor 2 bound with SST14.
Resolution: 2.85 Å
EM Method: Single-particle
Fitted PDBs: 7xat
Q-score: 0.545
Bo Q, Yang F, Li Y, Meng X, Zhang H, Zhou Y, Ling S, Sun D, Lv P, Liu L, Shi P, Tian C
Cell Discov (2022) 8 pp. 47-47 [ Pubmed: 35595746 DOI: doi:10.1038/s41421-022-00405-2 ]
- Somatostatin-14 (1 kDa, Protein from Homo sapiens)
- Scfv16 (32 kDa, Protein from Rattus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- The endogenous ligand sst14-bound somatostatin receptor 2 and gi heterotrimer complex. (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Bos taurus)
- Somatostatin receptor type 2,largebit (63 kDa, Protein from synthetic construct)
Structure of somatostatin receptor 2 bound with octreotide.
Resolution: 2.97 Å
EM Method: Single-particle
Fitted PDBs: 7xau
Q-score: 0.49
Bo Q, Yang F, Li Y, Meng X, Zhang H, Zhou Y, Ling S, Sun D, Lv P, Liu L, Shi P, Tian C
Cell Discov (2022) 8 pp. 47-47 [ Pubmed: 35595746 DOI: doi:10.1038/s41421-022-00405-2 ]
- The sst anologue octreotide bound somatostatin receptor 2 and gi heterotrimer complex (Complex from Homo sapiens)
- Scfv16 (32 kDa, Protein from Rattus)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Bos taurus)
- Octreotide (1 kDa, Protein from synthetic construct)
- Somatostatin receptor type 2,largebit (63 kDa, Protein from synthetic construct)
Structure of somatostatin receptor 2 bound with lanreotide.
Resolution: 2.87 Å
EM Method: Single-particle
Fitted PDBs: 7xav
Q-score: 0.514
Bo Q, Yang F, Li Y, Meng X, Zhang H, Zhou Y, Ling S, Sun D, Lv P, Liu L, Shi P, Tian C
Cell Discov (2022) 8 pp. 47-47 [ Pubmed: 35595746 DOI: doi:10.1038/s41421-022-00405-2 ]
- The sst analogue lanreotide-bound somatostatin receptor 2 and gi heterotrimer complex. (Complex from Homo sapiens)
- Scfv16 (32 kDa, Protein from Rattus)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Bos taurus)
- Lanreotide (1 kDa, Protein from synthetic construct)
- Somatostatin receptor type 2,largebit (63 kDa, Protein from synthetic construct)
Human Calcium-Sensing Receptor bound with calcium ions
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 7dtt
Q-score: 0.442
Ling S, Shi P, Liu S, Meng X, Zhou Y, Sun W, Chang S, Zhang X, Zhang L, Shi C, Sun D, Liu L, Tian C
Cell Res (2021) 31 pp. 383-394 [ Pubmed: 33603117 DOI: doi:10.1038/s41422-021-00474-0 ]
- Extracellular calcium-sensing receptor (123 kDa, Protein from Homo sapiens)
- Full-lenth human calcium-sensing receptor bound with 20 mm calcium ions (Complex from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)