HIV 16055.v8.3 SOSIP Env in Complex with V2 Epitope and Anti-Immune Complex pAbs from Rabbit 2464
Brown S, Antanasijevic A, Sewall LM, Garcia DM, Brouwer PJM, Sanders RW, Ward AB
Sci Immunol (2025) 10 pp. eadp5218-eadp5218 [ DOI: doi:10.1126/sciimmunol.adp5218 Pubmed: 39823319 ]
- Rabbit v2 polyclonal antibody - predicted heavy chain (10 kDa, Protein from Oryctolagus cuniculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Hiv-1 16055 sosip env in complex with rabbit polyclonal antibodies - v2 epitope and anti-immune complex pabs (Complex from Oryctolagus cuniculus)
- Rabbit anti-immune complex antibody - predicted heavy chain (9 kDa, Protein from Oryctolagus cuniculus)
- Rabbit anti-immune complex antibody - predicted light chain (9 kDa, Protein from Oryctolagus cuniculus)
- Rabbit v2 polyclonal antibody - predicted light chain (9 kDa, Protein from Oryctolagus cuniculus)
- Transmembrane protein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Surface protein gp120 (58 kDa, Protein from Human immunodeficiency virus 1)
HIV-1 B41 SOSIP.v4.1 Env in Complex with N241 Epitope and Anti-Immune Complex Antibodies
Brown S, Antanasijevic A, Sewall LM, Garcia DM, Brouwer PJM, Sanders RW, Ward AB
Sci Immunol (2025) 10 pp. eadp5218-eadp5218 [ DOI: doi:10.1126/sciimmunol.adp5218 Pubmed: 39823319 ]
HIV BG505.v5.2 (N289/N241) SOSIP Env in Complex with gp120-Interface pAb from Rh.33203
Brown S, Antanasijevic A, Sewall LM, Garcia DM, Brouwer PJM, Sanders RW, Ward AB
Sci Immunol (2025) 10 pp. eadp5218-eadp5218 [ DOI: doi:10.1126/sciimmunol.adp5218 Pubmed: 39823319 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Hiv-1 bg505 sosip env in complex with nhp polyclonal antibody - gp120-interface epitope (Complex from Macaca mulatta)
- Gp120-interface polyclonal antibody - predicted heavy chain (9 kDa, Protein from Macaca mulatta)
- Transmembrane protein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Surface protein gp120 (57 kDa, Protein from Human immunodeficiency virus 1)
- Gp120-interface polyclonal antibody - predicted light chain (8 kDa, Protein from Macaca mulatta)
HIV BG505.v5.2 (N289/N241) SOSIP Env in Complex with V5 pAb from Rh.33203
Brown S, Antanasijevic A, Sewall LM, Garcia DM, Brouwer PJM, Sanders RW, Ward AB
Sci Immunol (2025) 10 pp. eadp5218-eadp5218 [ DOI: doi:10.1126/sciimmunol.adp5218 Pubmed: 39823319 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Transmembrane protein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Nhp polyclonal antibody v5 epitope - predicted heavy chain (9 kDa, Protein from Macaca mulatta)
- Surface protein gp120 (57 kDa, Protein from Human immunodeficiency virus 1)
- Nhp polyclonal antibody v5 epitope - predicted light chain (8 kDa, Protein from Macaca mulatta)
- Hiv-1 bg505 sosip env in complex with nhp polyclonal antibody - v5 epitope (Complex from Macaca mulatta)
Brown S, Antanasijevic A, Sewall LM, Garcia DM, Brouwer PJM, Sanders RW, Ward AB
Sci Immunol (2025) 10 pp. eadp5218-eadp5218 [ DOI: doi:10.1126/sciimmunol.adp5218 Pubmed: 39823319 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Nhp anti-immune complex pab - predicted heavy chain (8 kDa, Protein from Macaca mulatta)
- Nhp anti-immune complex pab - predicted light chain (8 kDa, Protein from Macaca mulatta)
- Nhp v5 epitope pab - predicted light chain (8 kDa, Protein from Macaca mulatta)
- Transmembrane protein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Nhp gp120-interface epitope pab - predicted heavy chain (10 kDa, Protein from Macaca mulatta)
- Hiv-1 bg505 sosip env in complex with nhp polyclonal antibody - v5, gp120-interface, and anti-immune complex epitopes (Complex from Macaca mulatta)
- Nhp gp120-interface epitope pab - predicted light chain (8 kDa, Protein from Macaca mulatta)
- Surface protein gp120 (57 kDa, Protein from Human immunodeficiency virus 1)
- Nhp v5 epitope pab - predicted heavy chain (9 kDa, Protein from Macaca mulatta)
Resolution: 3.83 Å
EM Method: Single-particle
Fitted PDBs: 7t6x
Q-score: 0.381
Torrents de la Pena A, Sliepen K, Eshun-Wilson L, Newby ML, Allen JD, Zon I, Koekkoek S, Chumbe A, Crispin M, Schinkel J, Lander GC, Sanders RW, Ward AB
Science (2022) 378 pp. 263-269 [ DOI: doi:10.1126/science.abn9884 Pubmed: 36264808 ]
- At12009 crossmab, light kappa chain (24 kDa, Protein from Homo sapiens)
- At12009 crossmab, heavy chain (29 kDa, Protein from Homo sapiens)
- Envelope glycoprotein e1 (20 kDa, Protein from Hepacivirus C)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Envelope glycoprotein e2 (40 kDa, Protein from Hepacivirus C)
- Igh505, heavy chain (52 kDa, Protein from Homo sapiens)
- Cryoem structure of full-length hepatitis c virus e1e2 glycoprotein in complex with ar4a, at12009 and igh505 fabs (Complex from Hepacivirus C)
- Ar4a fab, heavy chain (29 kDa, Protein from Homo sapiens)
- Igh505, lambda light chain (24 kDa, Protein from Homo sapiens)
- Ar4a, kappa light chain (25 kDa, Protein from Homo sapiens)
AMC009 SOSIPv5.2 in complex with Fabs ACS101 and ACS124
Resolution: 3.95 Å
EM Method: Single-particle
Fitted PDBs: 7z3a
Q-score: 0.368
van Schooten J, Farokhi E, Schorcht A, van den Kerkhof TLGM, Gao H, van der Woude P, Burger JA, Meesters TGR, Bijl T, Ghalaiyini R, Turner HL, Dorning J, van Schaik BDC, van Kampen AHC, Labranche CC, Stanfield RL, Sok D, Montefiori DC, Burton DR, Seaman MS, Ozorowski G, Wilson IA, Sanders RW, Ward AB, van Gils MJ
Nat Commun (2022) 13 pp. 4515-4515 [ Pubmed: 35922441 DOI: doi:10.1038/s41467-022-32208-0 ]
- Amc009 sosipv5.2 in complex with fabs acs101 and acs124 (Complex from Human immunodeficiency virus 1)
- Acs124 light chain (11 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Acs124 heavy chain (13 kDa, Protein from Homo sapiens)
- Amc009 sosipv5.2 in complex with fabs acs101 and acs124 (Complex from Homo sapiens)
- Acs101 heavy chain (14 kDa, Protein from Homo sapiens)
- Acs101 light chain (11 kDa, Protein from Homo sapiens)
- Amc009 sosip.v5.2 envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Amc009 sosipv5.2 envelope glycoprotein gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
- Amc009 sosipv5.2 in complex with fabs acs101 and acs124 (17 MDa, Complex)
De novo designed icosahedral nanoparticle I53_dn5 presenting BG505-SOSIP, Cryo-EM Map
Antanasijevic A, Ueda G, Brouwer PJM, Copps J, Huang D, Allen JD, Cottrell CA, Yasmeen A, Sewall LM, Bontjer I, Ketas TJ, Turner HL, Berndsen ZT, Montefiori DC, Klasse PJ, Crispin M, Nemazee D, Moore JP, Sanders RW, King NP, Baker D, Ward AB
PLoS Pathog (2020) 16 pp. e1008665-e1008665 [ Pubmed: 32780770 DOI: doi:10.1371/journal.ppat.1008665 ]
- De novo designed icosahedral nanoparticle i53_dn5 displaying 20 copies of bg505-sosip trimer on the surface. nanoparticle consists of 60 copies of both subunits (bg505-sosip-i53_dn5b and i53_dn5a) (Complex from synthetic construct)
- Bg505-sosip-i53_dn5b (Protein from synthetic construct)
- I53_dn5a (Protein from synthetic construct)
Antanasijevic A, Ueda G, Brouwer PJM, Copps J, Huang D, Allen JD, Cottrell CA, Yasmeen A, Sewall LM, Bontjer I, Ketas TJ, Turner HL, Berndsen ZT, Montefiori DC, Klasse PJ, Crispin M, Nemazee D, Moore JP, Sanders RW, King NP, Baker D, Ward AB
PLoS Pathog (2020) 16 pp. e1008665-e1008665 [ Pubmed: 32780770 DOI: doi:10.1371/journal.ppat.1008665 ]
Resolution: 4.25 Å
EM Method: Single-particle
Fitted PDBs: 6vfk
Q-score: 0.316
Antanasijevic A, Ueda G, Brouwer PJM, Copps J, Huang D, Allen JD, Cottrell CA, Yasmeen A, Sewall LM, Bontjer I, Ketas TJ, Turner HL, Berndsen ZT, Montefiori DC, Klasse PJ, Crispin M, Nemazee D, Moore JP, Sanders RW, King NP, Baker D, Ward AB
PLoS Pathog (2020) 16 pp. e1008665-e1008665 [ Pubmed: 32780770 DOI: doi:10.1371/journal.ppat.1008665 ]
- T33_dn10b (31 kDa, Protein from synthetic construct)
- De novo designed tetrahedral nanoparticle t33_dn10 displaying 4 copies of bg505-sosip trimer on the surface. nanoparticle consists of 12 copies of both subunits (bg505-sosip-t33_dn10a and t33_dn10b) (Complex from synthetic construct)
- Bg505-sosip-t33_dn10a (88 kDa, Protein from synthetic construct)