TAS2R14 receptor bound to flufenamic acid and gustducin
Peri L, Matzov D, Huxley DR, Rainish A, Fierro F, Sapir L, Pfeiffer T, Waterloo L, Hubner H, Peleg Y, Gmeiner P, McCormick PJ, Weikert D, Niv MY, Shalev-Benami M
Nat Commun (2024) 15 pp. 9991-9991 [ Pubmed: 39557861 DOI: doi:10.1038/s41467-024-54157-6 ]
TAS2R14 receptor bound to flufenamic acid and gustducin
Peri L, Matzov D, Huxley DR, Rainish A, Fierro F, Sapir L, Pfeiffer T, Waterloo L, Hubner H, Peleg Y, Gmeiner P, McCormick PJ, Weikert D, Niv MY, Shalev-Benami M
Nat Commun (2024) 15 pp. 9991-9991 [ DOI: doi:10.1038/s41467-024-54157-6 Pubmed: 39557861 ]
TAS2R14 receptor bound to flufenamic acid and gustducin
Peri L, Matzov D, Huxley DR, Rainish A, Fierro F, Sapir L, Pfeiffer T, Waterloo L, Hubner H, Peleg Y, Gmeiner P, McCormick PJ, Weikert D, Niv MY, Shalev-Benami M
Nat Commun (2024) 15 pp. 9991-9991 [ Pubmed: 39557861 DOI: doi:10.1038/s41467-024-54157-6 ]
Resolution: 3.03 Å
EM Method: Single-particle
Fitted PDBs: 8rql
Q-score: 0.48
Peri L, Matzov D, Huxley DR, Rainish A, Fierro F, Sapir L, Pfeiffer T, Waterloo L, Hubner H, Peleg Y, Gmeiner P, McCormick PJ, Weikert D, Niv MY, Shalev-Benami M
Nat Commun (2024) 15 pp. 9991-9991 [ Pubmed: 39557861 DOI: doi:10.1038/s41467-024-54157-6 ]
- Taste receptor type 2 member 14 (36 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Scfv16 (27 kDa, Protein from Mus musculoides)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Scfv16 (antibody) (Complex from Mus musculoides)
- 2-[[3-(trifluoromethyl)phenyl]amino] benzoic acid (281 Da, Ligand)
- Human taste receptor type 2 member 14 in complex with g-proteins (Complex from Homo sapiens)
- Human taste receptor type 2 member 14 in complex with g-proteins (118 MDa, Complex)
- Guanine nucleotide-binding protein g(t) subunit alpha-3 (25 kDa, Protein from Homo sapiens)
OEA bound GPR3-Gs complex structure
Resolution: 3.03 Å
EM Method: Single-particle
Fitted PDBs: 8x2k
Q-score: 0.532
Chen G, Staffen N, Wu Z, Xu X, Pan J, Inoue A, Shi T, Gmeiner P, Du Y, Xu J
Cell Res (2024) 34 pp. 262-265 [ Pubmed: 38287118 DOI: doi:10.1038/s41422-023-00919-8 ]
- Scfv16 (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Isoform gnas-2 of guanine nucleotide-binding protein g(s) subunit alpha isoforms short (43 kDa, Protein from Homo sapiens)
- Scfv16 (27 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Gpr3 (Complex from Homo sapiens)
- Soluble cytochrome b562,g-protein coupled receptor 3 (50 kDa, Protein from Homo sapiens)
- (z)-n-(2-hydroxyethyl)octadec-9-enamide (325 Da, Ligand)
- Gpr3, guanine nucleotide-binding protein g(s) subunit alpha, guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1,guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from Homo sapiens)
- Gpr3-gs-scfv16 complex (150 kDa, Complex from Homo sapiens)
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8gdz
Q-score: 0.49
Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G
Nature (2024) 629 pp. 1182-1191 [ DOI: doi:10.1038/s41586-024-07153-1 Pubmed: 38480881 ]
- (5r,6r)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol (209 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Beta-2 adrenergic receptor (51 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (44 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Complex of beta-2 adrenergic receptor and gs heterotrimer (Complex from Homo sapiens)
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8ge1
Q-score: 0.504
Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G
Nature (2024) 629 pp. 1182-1191 [ DOI: doi:10.1038/s41586-024-07153-1 Pubmed: 38480881 ]
- Complex of beta-2 adrenergic receptor and gs heterotrimer (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Beta-2 adrenergic receptor (51 kDa, Protein from Homo sapiens)
- (5r,6r)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol (209 Da, Ligand)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (44 kDa, Protein from Homo sapiens)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8ge2
Q-score: 0.51
Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G
Nature (2024) 629 pp. 1182-1191 [ DOI: doi:10.1038/s41586-024-07153-1 Pubmed: 38480881 ]
- (5r,6r)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol (209 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (44 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Beta-2 adrenergic receptor (51 kDa, Protein from Homo sapiens)
- Complex of beta-2 adrenergic receptor and gs g protein heterotrimer (Complex from Homo sapiens)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8ge3
Q-score: 0.514
Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G
Nature (2024) 629 pp. 1182-1191 [ DOI: doi:10.1038/s41586-024-07153-1 Pubmed: 38480881 ]
- (5r,6r)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol (209 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Beta-2 adrenergic receptor (51 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (44 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Complex of beta-2 adrenergic receptor and gs heterotrimer (Complex from Homo sapiens)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8ge4
Q-score: 0.521
Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G
Nature (2024) 629 pp. 1182-1191 [ DOI: doi:10.1038/s41586-024-07153-1 Pubmed: 38480881 ]
- Water (18 Da, Ligand)
- (5r,6r)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol (209 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Beta-2 adrenergic receptor (51 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (44 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Complex of beta-2 adrenergic receptor and gs heterotrimer (Complex from Homo sapiens)