The open state of the yeast U4/U6.U5 tri-snRNP at 4.2 Angstrom
Nguyen TH, Galej WP, Bai XC, Oubridge C, Newman AJ, Scheres SH, Nagai K
Nature (2016) 530 pp. 298-302 [ DOI: doi:10.1038/nature16940 Pubmed: 26829225 ]
- Smd2 (11 kDa, Protein from Saccharomyces cerevisiae)
- Brr2 (202 kDa, Protein from Saccharomyces cerevisiae)
- U5 snrna (45 kDa, RNA from Saccharomyces cerevisiae)
- Lsm3 (8 kDa, Protein from Saccharomyces cerevisiae)
- Lsm4 (8 kDa, Protein from Saccharomyces cerevisiae)
- Sme (8 kDa, Protein from Saccharomyces cerevisiae)
- Prp6 (84 kDa, Protein from Saccharomyces cerevisiae)
- U5 smd1 (9 kDa, Protein from Saccharomyces cerevisiae)
- Smb (9 kDa, Protein from Saccharomyces cerevisiae)
- Lsm7 (7 kDa, Protein from Saccharomyces cerevisiae)
- Prp4 (39 kDa, Protein from Saccharomyces cerevisiae)
- Smg (7 kDa, Protein from Saccharomyces cerevisiae)
- Smd3 (9 kDa, Protein from Saccharomyces cerevisiae)
- U6 snrna (25 kDa, RNA from Saccharomyces cerevisiae)
- Smf (8 kDa, Protein from Saccharomyces cerevisiae)
- U4 smd1 (10 kDa, Protein from Saccharomyces cerevisiae)
- Snu13 (13 kDa, Protein from Saccharomyces cerevisiae)
- Lsm6 (8 kDa, Protein from Saccharomyces cerevisiae)
- Dib1 (16 kDa, Protein from Saccharomyces cerevisiae)
- Snu66 (24 kDa, Protein from Saccharomyces cerevisiae)
- Tri-snrnp complex with 30 proteins and 3 snrna (1 MDa, Complex from Saccharomyces cerevisiae)
- Prp31 (47 kDa, Protein from Saccharomyces cerevisiae)
- Lsm2 (10 kDa, Protein from Saccharomyces cerevisiae)
- Snu114 (97 kDa, Protein from Saccharomyces cerevisiae)
- U4 snrna (39 kDa, RNA from Saccharomyces cerevisiae)
- Prp8 (255 kDa, Protein from Saccharomyces cerevisiae)
- Lsm5 (8 kDa, Protein from Saccharomyces cerevisiae)
- Unknown proteins (8 kDa, Protein from Saccharomyces cerevisiae)
- Lsm8 (7 kDa, Protein from Saccharomyces cerevisiae)
- U5 sme (8 kDa, Protein from Saccharomyces cerevisiae)
- Prp3 (37 kDa, Protein from Saccharomyces cerevisiae)
The closed state of the yeast spliceosomal U4/U6.U5 tri-snRNP at 4.3 Angstrom
Nguyen TH, Galej WP, Bai XC, Oubridge C, Newman AJ, Scheres SH, Nagai K
Nature (2016) 530 pp. 298-302 [ DOI: doi:10.1038/nature16940 Pubmed: 26829225 ]
- Smd2 (11 kDa, Protein from Saccharomyces cerevisiae)
- Brr2 (202 kDa, Protein from Saccharomyces cerevisiae)
- U5 snrna (45 kDa, RNA from Saccharomyces cerevisiae)
- Lsm3 (8 kDa, Protein from Saccharomyces cerevisiae)
- Lsm4 (8 kDa, Protein from Saccharomyces cerevisiae)
- Sme (8 kDa, Protein from Saccharomyces cerevisiae)
- Prp6 (84 kDa, Protein from Saccharomyces cerevisiae)
- U5 smd1 (9 kDa, Protein from Saccharomyces cerevisiae)
- Smb (9 kDa, Protein from Saccharomyces cerevisiae)
- Lsm7 (7 kDa, Protein from Saccharomyces cerevisiae)
- Prp4 (39 kDa, Protein from Saccharomyces cerevisiae)
- Smg (7 kDa, Protein from Saccharomyces cerevisiae)
- Smd3 (9 kDa, Protein from Saccharomyces cerevisiae)
- U6 snrna (25 kDa, RNA from Saccharomyces cerevisiae)
- Smf (8 kDa, Protein from Saccharomyces cerevisiae)
- U4 smd1 (10 kDa, Protein from Saccharomyces cerevisiae)
- Snu13 (13 kDa, Protein from Saccharomyces cerevisiae)
- Lsm6 (8 kDa, Protein from Saccharomyces cerevisiae)
- Dib1 (16 kDa, Protein from Saccharomyces cerevisiae)
- Snu66 (24 kDa, Protein from Saccharomyces cerevisiae)
- Tri-snrnp complex with 30 proteins and 3 snrna (1 MDa, Complex from Saccharomyces cerevisiae)
- Prp31 (47 kDa, Protein from Saccharomyces cerevisiae)
- Lsm2 (10 kDa, Protein from Saccharomyces cerevisiae)
- Snu114 (97 kDa, Protein from Saccharomyces cerevisiae)
- U4 snrna (39 kDa, RNA from Saccharomyces cerevisiae)
- Prp8 (255 kDa, Protein from Saccharomyces cerevisiae)
- Lsm5 (8 kDa, Protein from Saccharomyces cerevisiae)
- Unknown proteins (8 kDa, Protein from Saccharomyces cerevisiae)
- Lsm8 (7 kDa, Protein from Saccharomyces cerevisiae)
- U5 sme (8 kDa, Protein from Saccharomyces cerevisiae)
- Prp3 (37 kDa, Protein from Saccharomyces cerevisiae)
Nguyen TH, Galej WP, Bai XC, Oubridge C, Newman AJ, Scheres SH, Nagai K
Nature (2016) 530 pp. 298-302 [ DOI: doi:10.1038/nature16940 Pubmed: 26829225 ]
- Smd2 (11 kDa, Protein from Saccharomyces cerevisiae)
- Brr2 (202 kDa, Protein from Saccharomyces cerevisiae)
- U5 snrna (45 kDa, RNA from Saccharomyces cerevisiae)
- Lsm3 (8 kDa, Protein from Saccharomyces cerevisiae)
- Lsm4 (8 kDa, Protein from Saccharomyces cerevisiae)
- Sme (8 kDa, Protein from Saccharomyces cerevisiae)
- Prp6 (84 kDa, Protein from Saccharomyces cerevisiae)
- U5 smd1 (9 kDa, Protein from Saccharomyces cerevisiae)
- Smb (9 kDa, Protein from Saccharomyces cerevisiae)
- Lsm7 (7 kDa, Protein from Saccharomyces cerevisiae)
- Prp4 (39 kDa, Protein from Saccharomyces cerevisiae)
- Smg (7 kDa, Protein from Saccharomyces cerevisiae)
- Smd3 (9 kDa, Protein from Saccharomyces cerevisiae)
- U6 snrna (25 kDa, RNA from Saccharomyces cerevisiae)
- Smf (8 kDa, Protein from Saccharomyces cerevisiae)
- U4 smd1 (10 kDa, Protein from Saccharomyces cerevisiae)
- Snu13 (13 kDa, Protein from Saccharomyces cerevisiae)
- Lsm6 (8 kDa, Protein from Saccharomyces cerevisiae)
- Dib1 (16 kDa, Protein from Saccharomyces cerevisiae)
- Snu66 (24 kDa, Protein from Saccharomyces cerevisiae)
- Tri-snrnp complex with 30 proteins and 3 snrna (1 MDa, Complex from Saccharomyces cerevisiae)
- Prp31 (47 kDa, Protein from Saccharomyces cerevisiae)
- Lsm2 (10 kDa, Protein from Saccharomyces cerevisiae)
- Snu114 (97 kDa, Protein from Saccharomyces cerevisiae)
- U4 snrna (39 kDa, RNA from Saccharomyces cerevisiae)
- Prp8 (255 kDa, Protein from Saccharomyces cerevisiae)
- Lsm5 (8 kDa, Protein from Saccharomyces cerevisiae)
- Unknown proteins (8 kDa, Protein from Saccharomyces cerevisiae)
- Lsm8 (7 kDa, Protein from Saccharomyces cerevisiae)
- U5 sme (8 kDa, Protein from Saccharomyces cerevisiae)
- Prp3 (37 kDa, Protein from Saccharomyces cerevisiae)
Nguyen TH, Galej WP, Bai XC, Oubridge C, Newman AJ, Scheres SH, Nagai K
Nature (2016) 530 pp. 298-302 [ DOI: doi:10.1038/nature16940 Pubmed: 26829225 ]
- Smd2 (11 kDa, Protein from Saccharomyces cerevisiae)
- Brr2 (202 kDa, Protein from Saccharomyces cerevisiae)
- U5 snrna (45 kDa, RNA from Saccharomyces cerevisiae)
- Lsm3 (8 kDa, Protein from Saccharomyces cerevisiae)
- Lsm4 (8 kDa, Protein from Saccharomyces cerevisiae)
- Sme (8 kDa, Protein from Saccharomyces cerevisiae)
- Prp6 (84 kDa, Protein from Saccharomyces cerevisiae)
- U5 smd1 (9 kDa, Protein from Saccharomyces cerevisiae)
- Smb (9 kDa, Protein from Saccharomyces cerevisiae)
- Lsm7 (7 kDa, Protein from Saccharomyces cerevisiae)
- Prp4 (39 kDa, Protein from Saccharomyces cerevisiae)
- Smg (7 kDa, Protein from Saccharomyces cerevisiae)
- Smd3 (9 kDa, Protein from Saccharomyces cerevisiae)
- U6 snrna (25 kDa, RNA from Saccharomyces cerevisiae)
- Smf (8 kDa, Protein from Saccharomyces cerevisiae)
- U4 smd1 (10 kDa, Protein from Saccharomyces cerevisiae)
- Snu13 (13 kDa, Protein from Saccharomyces cerevisiae)
- Lsm6 (8 kDa, Protein from Saccharomyces cerevisiae)
- Dib1 (16 kDa, Protein from Saccharomyces cerevisiae)
- Snu66 (24 kDa, Protein from Saccharomyces cerevisiae)
- Tri-snrnp complex with 30 proteins and 3 snrna (1 MDa, Complex from Saccharomyces cerevisiae)
- Prp31 (47 kDa, Protein from Saccharomyces cerevisiae)
- Lsm2 (10 kDa, Protein from Saccharomyces cerevisiae)
- Snu114 (97 kDa, Protein from Saccharomyces cerevisiae)
- U4 snrna (39 kDa, RNA from Saccharomyces cerevisiae)
- Prp8 (255 kDa, Protein from Saccharomyces cerevisiae)
- Lsm5 (8 kDa, Protein from Saccharomyces cerevisiae)
- Unknown proteins (8 kDa, Protein from Saccharomyces cerevisiae)
- Lsm8 (7 kDa, Protein from Saccharomyces cerevisiae)
- U5 sme (8 kDa, Protein from Saccharomyces cerevisiae)
- Prp3 (37 kDa, Protein from Saccharomyces cerevisiae)
Nguyen TH, Galej WP, Bai XC, Oubridge C, Newman AJ, Scheres SH, Nagai K
Nature (2016) 530 pp. 298-302 [ DOI: doi:10.1038/nature16940 Pubmed: 26829225 ]
- Smd2 (11 kDa, Protein from Saccharomyces cerevisiae)
- Brr2 (202 kDa, Protein from Saccharomyces cerevisiae)
- U5 snrna (45 kDa, RNA from Saccharomyces cerevisiae)
- Lsm3 (8 kDa, Protein from Saccharomyces cerevisiae)
- Lsm4 (8 kDa, Protein from Saccharomyces cerevisiae)
- Sme (8 kDa, Protein from Saccharomyces cerevisiae)
- Prp6 (84 kDa, Protein from Saccharomyces cerevisiae)
- U5 smd1 (9 kDa, Protein from Saccharomyces cerevisiae)
- Smb (9 kDa, Protein from Saccharomyces cerevisiae)
- Lsm7 (7 kDa, Protein from Saccharomyces cerevisiae)
- Prp4 (39 kDa, Protein from Saccharomyces cerevisiae)
- Smg (7 kDa, Protein from Saccharomyces cerevisiae)
- Smd3 (9 kDa, Protein from Saccharomyces cerevisiae)
- U6 snrna (25 kDa, RNA from Saccharomyces cerevisiae)
- Smf (8 kDa, Protein from Saccharomyces cerevisiae)
- U4 smd1 (10 kDa, Protein from Saccharomyces cerevisiae)
- Snu13 (13 kDa, Protein from Saccharomyces cerevisiae)
- Lsm6 (8 kDa, Protein from Saccharomyces cerevisiae)
- Dib1 (16 kDa, Protein from Saccharomyces cerevisiae)
- Snu66 (24 kDa, Protein from Saccharomyces cerevisiae)
- Tri-snrnp complex with 30 proteins and 3 snrna (1 MDa, Complex from Saccharomyces cerevisiae)
- Prp31 (47 kDa, Protein from Saccharomyces cerevisiae)
- Lsm2 (10 kDa, Protein from Saccharomyces cerevisiae)
- Snu114 (97 kDa, Protein from Saccharomyces cerevisiae)
- U4 snrna (39 kDa, RNA from Saccharomyces cerevisiae)
- Prp8 (255 kDa, Protein from Saccharomyces cerevisiae)
- Lsm5 (8 kDa, Protein from Saccharomyces cerevisiae)
- Unknown proteins (8 kDa, Protein from Saccharomyces cerevisiae)
- Lsm8 (7 kDa, Protein from Saccharomyces cerevisiae)
- U5 sme (8 kDa, Protein from Saccharomyces cerevisiae)
- Prp3 (37 kDa, Protein from Saccharomyces cerevisiae)
Foot region of the yeast spliceosomal U4/U6.U5 tri-snRNP
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 5gam
Q-score: 0.363
Nguyen THD, Galej WP, Bai XC, Oubridge C, Scheres SHW, Newman AJ, Nagai K
Nature (2016) 530 pp. 298-302 [ DOI: doi:10.1038/nature16940 Pubmed: 26829225 ]
- Small nuclear ribonucleoprotein f (9 kDa, Protein from Saccharomyces cerevisiae)
- Small nuclear ribonucleoprotein sm d2 (12 kDa, Protein from Saccharomyces cerevisiae)
- U6 snrna, 5' end (9 kDa, RNA from Saccharomyces cerevisiae)
- Small nuclear ribonucleoprotein g (8 kDa, Protein from Saccharomyces cerevisiae)
- Unknown polypeptide (1 kDa, Protein from Saccharomyces cerevisiae)
- Foot region of the yeast spliceosomal u4/u6.u5 tri-snrnp (350 kDa, Complex from Saccharomyces cerevisiae)
- Small nuclear ribonucleoprotein-associated protein b (22 kDa, Protein from Saccharomyces cerevisiae)
- Small nuclear ribonucleoprotein sm d3 (11 kDa, Protein from Saccharomyces cerevisiae)
- Pre-mrna-splicing factor 8 (85 kDa, Protein from Saccharomyces cerevisiae)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Pre-mrna-splicing factor snu114 (114 kDa, Protein from Saccharomyces cerevisiae)
- U5 snrna (57 kDa, RNA from Saccharomyces cerevisiae)
- Small nuclear ribonucleoprotein sm d1 (16 kDa, Protein from Saccharomyces cerevisiae)
- Small nuclear ribonucleoprotein e (10 kDa, Protein from Saccharomyces cerevisiae)
The overall structure of the yeast spliceosomal U4/U6.U5 tri-snRNP at 3.7 Angstrom
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 5gan
Q-score: 0.254
Nguyen TH, Galej WP, Bai XC, Oubridge C, Newman AJ, Scheres SH, Nagai K
Nature (2016) 530 pp. 298-302 [ DOI: doi:10.1038/nature16940 Pubmed: 26829225 ]
- Pre-mrna-splicing factor 6 (104 kDa, Protein from Saccharomyces cerevisiae)
- Small nuclear ribonucleoprotein f (9 kDa, Protein from Saccharomyces cerevisiae)
- U6 snrna-associated sm-like protein lsm7 (13 kDa, Protein from Saccharomyces cerevisiae)
- U5 snrna (68 kDa, RNA from Saccharomyces cerevisiae)
- Small nuclear ribonucleoprotein sm d3 (11 kDa, Protein from Saccharomyces cerevisiae)
- Small nuclear ribonucleoprotein g (8 kDa, Protein from Saccharomyces cerevisiae)
- U4/u6 small nuclear ribonucleoprotein prp3 (55 kDa, Protein from Saccharomyces cerevisiae)
- U6 snrna (35 kDa, RNA from Saccharomyces cerevisiae)
- Pre-mrna-processing factor 31 (56 kDa, Protein from Saccharomyces cerevisiae)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- U4/u6 small nuclear ribonucleoprotein prp4 (52 kDa, Protein from Saccharomyces cerevisiae)
- Unknown protein (8 kDa, Protein from Saccharomyces cerevisiae)
- U6 snrna-associated sm-like protein lsm6 (9 kDa, Protein from Saccharomyces cerevisiae)
- Pre-mrna-splicing helicase brr2 (246 kDa, Protein from Saccharomyces cerevisiae)
- Small nuclear ribonucleoprotein-associated protein b (22 kDa, Protein from Saccharomyces cerevisiae)
- 13 kda ribonucleoprotein-associated protein (13 kDa, Protein from Saccharomyces cerevisiae)
- Spliceosomal protein dib1 (16 kDa, Protein from Saccharomyces cerevisiae)
- Pre-mrna-splicing factor snu114 (114 kDa, Protein from Saccharomyces cerevisiae)
- Small nuclear ribonucleoprotein sm d1 (16 kDa, Protein from Saccharomyces cerevisiae)
- U6 snrna-associated sm-like protein lsm3 (10 kDa, Protein from Saccharomyces cerevisiae)
- Small nuclear ribonucleoprotein e (10 kDa, Protein from Saccharomyces cerevisiae)
- Pre-mrna-splicing factor 8 (279 kDa, Protein from Saccharomyces cerevisiae)
- Snu66 (28 kDa, Protein from Saccharomyces cerevisiae)
- U6 snrna-associated sm-like protein lsm4 (21 kDa, Protein from Saccharomyces cerevisiae)
- U6 snrna-associated sm-like protein lsm8 (12 kDa, Protein from Saccharomyces cerevisiae)
- The overall structure of the yeast spliceosomal u4/u6.u5 tri-snrnp (1 MDa, Complex from Saccharomyces cerevisiae)
- U4 snrna (51 kDa, RNA from Saccharomyces cerevisiae)
- U6 snrna-associated sm-like protein lsm5 (10 kDa, Protein from Saccharomyces cerevisiae)
- Small nuclear ribonucleoprotein sm d2 (12 kDa, Protein from Saccharomyces cerevisiae)
- U6 snrna-associated sm-like protein lsm2 (11 kDa, Protein from Saccharomyces cerevisiae)
Head region of the yeast spliceosomal U4/U6.U5 tri-snRNP
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 5gao
Q-score: 0.305
Nguyen TH, Galej WP, Bai XC, Oubridge C, Newman AJ, Scheres SH, Nagai K
Nature (2016) 530 pp. 298-302 [ DOI: doi:10.1038/nature16940 Pubmed: 26829225 ]
- Small nuclear ribonucleoprotein f (9 kDa, Protein from Saccharomyces cerevisiae)
- Small nuclear ribonucleoprotein sm d3 (11 kDa, Protein from Saccharomyces cerevisiae)
- Small nuclear ribonucleoprotein g (8 kDa, Protein from Saccharomyces cerevisiae)
- Small nuclear ribonucleoprotein-associated protein b (22 kDa, Protein from Saccharomyces cerevisiae)
- Snu66 (25 kDa, Protein from Saccharomyces cerevisiae)
- Saccharomyces cerevisiae strain uoa_m2 chromosome 5 sequence (30 kDa, RNA from Saccharomyces cerevisiae)
- Pre-mrna-splicing factor 8 (30 kDa, Protein from Saccharomyces cerevisiae)
- Head region of the yeast spliceosomal u4/u6.u5 tri-snrnp (400 kDa, Complex from Saccharomyces cerevisiae)
- Small nuclear ribonucleoprotein sm d1 (16 kDa, Protein from Saccharomyces cerevisiae)
- Small nuclear ribonucleoprotein e (10 kDa, Protein from Saccharomyces cerevisiae)
- Pre-mrna-splicing helicase brr2 (246 kDa, Protein from Saccharomyces cerevisiae)
- Small nuclear ribonucleoprotein sm d2 (12 kDa, Protein from Saccharomyces cerevisiae)
Body region of the U4/U6.U5 tri-snRNP
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 5gap
Q-score: 0.397
Nguyen TH, Galej WP, Bai XC, Oubridge C, Newman AJ, Scheres SH, Nagai K
Nature (2016) 530 pp. 298-302 [ DOI: doi:10.1038/nature16940 Pubmed: 26829225 ]
- Pre-mrna-splicing factor 6 (104 kDa, Protein from Saccharomyces cerevisiae)
- Unknown protein (6 kDa, Protein from Saccharomyces cerevisiae)
- U4 snrna, 5' region, nucleotides 1-67 (21 kDa, RNA from Saccharomyces cerevisiae)
- U4/u6 small nuclear ribonucleoprotein prp3 (55 kDa, Protein from Saccharomyces cerevisiae)
- 13 kda ribonucleoprotein-associated protein (13 kDa, Protein from Saccharomyces cerevisiae)
- U6 snrna (35 kDa, RNA from Saccharomyces cerevisiae)
- Pre-mrna-processing factor 31 (56 kDa, Protein from Saccharomyces cerevisiae)
- Spliceosomal protein dib1 (16 kDa, Protein from Saccharomyces cerevisiae)
- U4/u6 small nuclear ribonucleoprotein prp4 (52 kDa, Protein from Saccharomyces cerevisiae)
- Pre-mrna-splicing factor 8 (279 kDa, Protein from Saccharomyces cerevisiae)
- Body region of the u4/u6.u5 tri-snrnp complex (500 kDa, Complex from Saccharomyces cerevisiae)
- Pre-mrna-splicing helicase brr2 (246 kDa, Protein from Saccharomyces cerevisiae)
- U5 snrna (68 kDa, RNA from Saccharomyces cerevisiae)
EM structure of the yeast spliceosomal U4/U6.U5 tri-snRNP
Nguyen THD, Galej WP, Bai X-C, Savva CG, Newman AJ, Scheres SHW, Nagai K
Nature (2015) 523 pp. 47-52 [ DOI: doi:10.1038/nature14548 Pubmed: 26106855 ]
- U6 snrna (RNA from Saccharomyces cerevisiae)
- Yeast u4/u6.u5 tri-snrnp (1 MDa, Sample)
- U4/u6.u5 tri-snrnp (Protein from Saccharomyces cerevisiae)
- U5 snrna (RNA from Saccharomyces cerevisiae)
- U4 snrna (RNA from Saccharomyces cerevisiae)