Cryo-EM structure of insulin amyloid-like fibril that is composed of two antiparallel protofilaments
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8sbd
Q-score: 0.466
Wang L, Hall CE, Uchikawa E, Chen D, Choi E, Zhang X, Bai XC
Sci Adv (2023) 9 pp. eadi1057-eadi1057 [ Pubmed: 37713485 DOI: doi:10.1126/sciadv.adi1057 ]
Human alpha3 Na+/K+-ATPase in its Na+-occluded state
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 8d3u
Q-score: 0.444
Nguyen PT, Deisl C, Fine M, Tippetts TS, Uchikawa E, Bai XC, Levine B
Nat Commun (2022) 13 pp. 5293-5293 [ Pubmed: 36075933 DOI: doi:10.1038/s41467-022-32990-x ]
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Sodium/potassium-transporting atpase subunit alpha-3 (111 kDa, Protein from Homo sapiens)
- Na+/k+-atpase (Complex from Homo sapiens)
- Fxyd domain-containing ion transport regulator 6 (10 kDa, Protein from Homo sapiens)
- Sodium/potassium-transporting atpase subunit beta-1 (35 kDa, Protein from Homo sapiens)
- Tetrafluoroaluminate ion (102 Da, Ligand)
Human alpha3 Na+/K+-ATPase in its cytoplasmic side-open state
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8d3v
Q-score: 0.495
Nguyen PT, Deisl C, Fine M, Tippetts TS, Uchikawa E, Bai XC, Levine B
Nat Commun (2022) 13 pp. 5293-5293 [ Pubmed: 36075933 DOI: doi:10.1038/s41467-022-32990-x ]
- Sodium/potassium-transporting atpase subunit alpha-3 (111 kDa, Protein from Homo sapiens)
- Fxyd domain-containing ion transport regulator 6 (10 kDa, Protein from Homo sapiens)
- Sodium/potassium-transporting atpase subunit beta-1 (35 kDa, Protein from Homo sapiens)
- Na+/k+-atpase (Complex from Homo sapiens)
Human alpha3 Na+/K+-ATPase in its AMPPCP-bound cytoplasmic side-open state
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8d3w
Q-score: 0.493
Nguyen PT, Deisl C, Fine M, Tippetts TS, Uchikawa E, Bai XC, Levine B
Nat Commun (2022) 13 pp. 5293-5293 [ Pubmed: 36075933 DOI: doi:10.1038/s41467-022-32990-x ]
- Sodium/potassium-transporting atpase subunit alpha-3 (111 kDa, Protein from Homo sapiens)
- Na+/k+-atpase (Complex from Homo sapiens)
- Fxyd domain-containing ion transport regulator 6 (10 kDa, Protein from Homo sapiens)
- Phosphomethylphosphonic acid adenylate ester (505 Da, Ligand)
- Sodium/potassium-transporting atpase subunit beta-1 (35 kDa, Protein from Homo sapiens)
Human alpha3 Na+/K+-ATPase in its K+-occluded state
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 8d3x
Q-score: 0.416
Nguyen PT, Deisl C, Fine M, Tippetts TS, Uchikawa E, Bai XC, Levine B
Nat Commun (2022) 13 pp. 5293-5293 [ Pubmed: 36075933 DOI: doi:10.1038/s41467-022-32990-x ]
- Sodium/potassium-transporting atpase subunit alpha-3 (111 kDa, Protein from Homo sapiens)
- Na+/k+-atpase (Complex from Homo sapiens)
- Fxyd domain-containing ion transport regulator 6 (10 kDa, Protein from Homo sapiens)
- Tetrafluoromagnesate(2-) (100 Da, Ligand)
- Sodium/potassium-transporting atpase subunit beta-1 (35 kDa, Protein from Homo sapiens)
Human alpha3 Na+/K+-ATPase in its exoplasmic side-open state
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 8d3y
Q-score: 0.438
Nguyen PT, Deisl C, Fine M, Tippetts TS, Uchikawa E, Bai XC, Levine B
Nat Commun (2022) 13 pp. 5293-5293 [ Pubmed: 36075933 DOI: doi:10.1038/s41467-022-32990-x ]
- Fxyd domain-containing ion transport regulator 6 (10 kDa, Protein from Homo sapiens)
- Sodium/potassium-transporting atpase subunit alpha-3 (111 kDa, Protein from Homo sapiens)
- Sodium/potassium-transporting atpase subunit beta-1 (35 kDa, Protein from Homo sapiens)
- Na+/k+-atpase (Complex from Homo sapiens)
Full-length insulin receptor bound with site 1 binding deficient mutant insulin (A-V3E)
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7sl1
Q-score: 0.433
Li J, Park J, Mayer JP, Webb KJ, Uchikawa E, Wu J, Liu S, Zhang X, Stowell MHB, Choi E, Bai XC
Nat Struct Mol Biol (2022) 29 pp. 357-368 [ Pubmed: 35361965 DOI: doi:10.1038/s41594-022-00750-6 ]
- Insulin a chain (2 kDa, Protein from Homo sapiens)
- Insulin b chain (3 kDa, Protein from Homo sapiens)
- Full-length insulin receptor bound with site 1 binding deficient mutant insulin (a-v3e) (Complex)
- Insulin receptor (155 kDa, Protein from Mus musculus)
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 7sl2
Q-score: 0.39
Li J, Park J, Mayer JP, Webb KJ, Uchikawa E, Wu J, Liu S, Zhang X, Stowell MHB, Choi E, Bai XC
Nat Struct Mol Biol (2022) 29 pp. 357-368 [ Pubmed: 35361965 DOI: doi:10.1038/s41594-022-00750-6 ]
- Insulin b chain (3 kDa, Protein from Homo sapiens)
- Insulin receptor (155 kDa, Protein from Mus musculus)
- Full-length insulin receptor bound with site 2 binding deficient mutant insulin (a-l13r) -- asymmetric conformation (Complex)
- Insulin a chain (2 kDa, Protein from Homo sapiens)
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7sl3
Q-score: 0.417
Li J, Park J, Mayer JP, Webb KJ, Uchikawa E, Wu J, Liu S, Zhang X, Stowell MHB, Choi E, Bai XC
Nat Struct Mol Biol (2022) 29 pp. 357-368 [ Pubmed: 35361965 DOI: doi:10.1038/s41594-022-00750-6 ]
- Insulin b chain (3 kDa, Protein from Homo sapiens)
- Insulin receptor (155 kDa, Protein from Mus musculus)
- Full-length insulin receptor bound with site 2 binding deficient mutant insulin (a-l13r) -- symmetric conformation (Complex)
- Insulin a chain (2 kDa, Protein from Homo sapiens)
Resolution: 5.0 Å
EM Method: Single-particle
Fitted PDBs: 7sl4
Q-score: 0.258
Li J, Park J, Mayer JP, Webb KJ, Uchikawa E, Wu J, Liu S, Zhang X, Stowell MHB, Choi E, Bai XC
Nat Struct Mol Biol (2022) 29 pp. 357-368 [ Pubmed: 35361965 DOI: doi:10.1038/s41594-022-00750-6 ]
- Insulin receptor (155 kDa, Protein from Mus musculus)
- Insulin b chain (3 kDa, Protein from Homo sapiens)
- Full-length insulin receptor bound with site 2 binding deficient mutant insulin (b-l17r) -- asymmetric conformation (Complex)
- Insulin a chain (2 kDa, Protein from Homo sapiens)