Cryo-EM structure of insulin receptor (IR) bound with S597 peptide
Resolution: 5.4 Å
EM Method: Single-particle
Fitted PDBs: 8dtl
Q-score: 0.141
Park J, Li J, Mayer JP, Ball KA, Wu J, Hall C, Accili D, Stowell MHB, Bai XC, Choi E
Nat Commun (2022) 13 pp. 5594-5594 [ Pubmed: 36151101 DOI: doi:10.1038/s41467-022-33274-0 ]
- Insulin receptor (153 kDa, Protein from Mus musculus)
- Insulin mimetic peptide s597 (3 kDa, Protein from synthetic construct)
- Insulin receptor bound with s597 peptide (Complex from Mus musculus)
Cryo-EM structure of insulin receptor (IR) bound with S597 component 2
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8dtm
Q-score: 0.506
Park J, Li J, Mayer JP, Ball KA, Wu J, Hall C, Accili D, Stowell MHB, Bai XC, Choi E
Nat Commun (2022) 13 pp. 5594-5594 [ Pubmed: 36151101 DOI: doi:10.1038/s41467-022-33274-0 ]
- Insulin receptor (153 kDa, Protein from Mus musculus)
- Insulin mimetic peptide s597 component 2 (2 kDa, Protein from synthetic construct)
- Insulin receptor bound with s597 component 2 (Complex from Mus musculus)
Full-length insulin receptor bound with site 1 binding deficient mutant insulin (A-V3E)
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7sl1
Q-score: 0.433
Li J, Park J, Mayer JP, Webb KJ, Uchikawa E, Wu J, Liu S, Zhang X, Stowell MHB, Choi E, Bai XC
Nat Struct Mol Biol (2022) 29 pp. 357-368 [ Pubmed: 35361965 DOI: doi:10.1038/s41594-022-00750-6 ]
- Insulin a chain (2 kDa, Protein from Homo sapiens)
- Insulin b chain (3 kDa, Protein from Homo sapiens)
- Full-length insulin receptor bound with site 1 binding deficient mutant insulin (a-v3e) (Complex)
- Insulin receptor (155 kDa, Protein from Mus musculus)
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 7sl2
Q-score: 0.39
Li J, Park J, Mayer JP, Webb KJ, Uchikawa E, Wu J, Liu S, Zhang X, Stowell MHB, Choi E, Bai XC
Nat Struct Mol Biol (2022) 29 pp. 357-368 [ Pubmed: 35361965 DOI: doi:10.1038/s41594-022-00750-6 ]
- Insulin b chain (3 kDa, Protein from Homo sapiens)
- Insulin receptor (155 kDa, Protein from Mus musculus)
- Full-length insulin receptor bound with site 2 binding deficient mutant insulin (a-l13r) -- asymmetric conformation (Complex)
- Insulin a chain (2 kDa, Protein from Homo sapiens)
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7sl3
Q-score: 0.417
Li J, Park J, Mayer JP, Webb KJ, Uchikawa E, Wu J, Liu S, Zhang X, Stowell MHB, Choi E, Bai XC
Nat Struct Mol Biol (2022) 29 pp. 357-368 [ Pubmed: 35361965 DOI: doi:10.1038/s41594-022-00750-6 ]
- Insulin b chain (3 kDa, Protein from Homo sapiens)
- Insulin receptor (155 kDa, Protein from Mus musculus)
- Full-length insulin receptor bound with site 2 binding deficient mutant insulin (a-l13r) -- symmetric conformation (Complex)
- Insulin a chain (2 kDa, Protein from Homo sapiens)
Resolution: 5.0 Å
EM Method: Single-particle
Fitted PDBs: 7sl4
Q-score: 0.258
Li J, Park J, Mayer JP, Webb KJ, Uchikawa E, Wu J, Liu S, Zhang X, Stowell MHB, Choi E, Bai XC
Nat Struct Mol Biol (2022) 29 pp. 357-368 [ Pubmed: 35361965 DOI: doi:10.1038/s41594-022-00750-6 ]
- Insulin receptor (155 kDa, Protein from Mus musculus)
- Insulin b chain (3 kDa, Protein from Homo sapiens)
- Full-length insulin receptor bound with site 2 binding deficient mutant insulin (b-l17r) -- asymmetric conformation (Complex)
- Insulin a chain (2 kDa, Protein from Homo sapiens)
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 7sl6
Q-score: 0.39
Li J, Park J, Mayer JP, Webb KJ, Uchikawa E, Wu J, Liu S, Zhang X, Stowell MHB, Choi E, Bai XC
Nat Struct Mol Biol (2022) 29 pp. 357-368 [ Pubmed: 35361965 DOI: doi:10.1038/s41594-022-00750-6 ]
- Full-length insulin receptor bound with site 2 binding deficient mutant insulin (b-l17r) -- symmetric conformation (Complex)
- Insulin b chain (3 kDa, Protein from Homo sapiens)
- Insulin receptor (155 kDa, Protein from Mus musculus)
- Insulin a chain (2 kDa, Protein from Homo sapiens)
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7sl7
Q-score: 0.412
Li J, Park J, Mayer JP, Webb KJ, Uchikawa E, Wu J, Liu S, Zhang X, Stowell MHB, Choi E, Bai XC
Nat Struct Mol Biol (2022) 29 pp. 357-368 [ Pubmed: 35361965 DOI: doi:10.1038/s41594-022-00750-6 ]
- Insulin a chain (v3e) (2 kDa, Protein from Homo sapiens)
- Insulin a chain (l13r) (2 kDa, Protein from Homo sapiens)
- Full-length insulin receptor bound with both site 1 binding deficient mutant insulin (a-v3e) and site 2 binding deficient mutant insulin (a-l13r) (Complex)
- Insulin b chain (3 kDa, Protein from Homo sapiens)
- Insulin receptor (155 kDa, Protein from Mus musculus)
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7sth
Q-score: 0.415
Li J, Park J, Mayer JP, Webb KJ, Uchikawa E, Wu J, Liu S, Zhang X, Stowell MHB, Choi E, Bai XC
Nat Struct Mol Biol (2022) 29 pp. 357-368 [ Pubmed: 35361965 DOI: doi:10.1038/s41594-022-00750-6 ]
- Insulin (11 kDa, Protein from Homo sapiens)
- Insulin receptor (155 kDa, Protein from Mus musculus)
- Full-length insulin receptor bound with unsaturated insulin wt (2 insulin bound) symmetric conformation (Complex from Mus musculus)
Resolution: 4.9 Å
EM Method: Single-particle
Fitted PDBs: 7sti
Q-score: 0.209
Li J, Park J, Mayer JP, Webb KJ, Uchikawa E, Wu J, Liu S, Zhang X, Stowell MHB, Choi E, Bai XC
Nat Struct Mol Biol (2022) 29 pp. 357-368 [ Pubmed: 35361965 DOI: doi:10.1038/s41594-022-00750-6 ]
- Insulin (11 kDa, Protein from Homo sapiens)
- Insulin receptor (155 kDa, Protein from Mus musculus)
- Full-length insulin receptor bound with unsaturated insulin wt (1 insulin bound) asymmetric conformation (Complex from Mus musculus)