Structure of a spliceosome remodeled for exon ligation
Resolution: 3.85 Å
EM Method: Single-particle
Fitted PDBs: 5mps
Q-score: 0.356
Fica SM, Oubridge C, Galej WP, Wilkinson ME, Bai XC, Newman AJ, Nagai K
Nature (2017) 542 pp. 377-380 [ DOI: doi:10.1038/nature21078 Pubmed: 28076345 ]
- Small nuclear ribonucleoprotein f (9 kDa, Protein from Saccharomyces cerevisiae)
- Ubc4 gene exon (6 kDa, RNA from Saccharomyces cerevisiae)
- Pre-mrna-splicing factor slu7 (44 kDa, Protein from Saccharomyces cerevisiae)
- Pre-mrna-splicing factor bud31 (18 kDa, Protein from Saccharomyces cerevisiae)
- Pre-mrna-splicing factor cef1 (67 kDa, Protein from Saccharomyces cerevisiae)
- Pre-mrna-splicing factor 18 (28 kDa, Protein from Saccharomyces cerevisiae)
- Pre-mrna-splicing factor slt11 (40 kDa, Protein from Saccharomyces cerevisiae)
- Pre-mrna-splicing factor cwc22 (67 kDa, Protein from Saccharomyces cerevisiae)
- Yeast ubc4 gene for ubiquitin-conjugating enzyme (30 kDa, RNA from Saccharomyces cerevisiae)
- Small nuclear ribonucleoprotein sm d3 (11 kDa, Protein from Saccharomyces cerevisiae)
- Small nuclear ribonucleoprotein g (8 kDa, Protein from Saccharomyces cerevisiae)
- U2 snrna (376 kDa, RNA from Saccharomyces cerevisiae)
- Potassium ion (39 Da, Ligand)
- Pre-mrna-processing protein 45 (42 kDa, Protein from Saccharomyces cerevisiae)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Unknown (5 kDa, Protein from Saccharomyces cerevisiae)
- Pre-mrna-splicing factor cwc21 (15 kDa, Protein from Saccharomyces cerevisiae)
- Pre-mrna-splicing factor clf1 (82 kDa, Protein from Saccharomyces cerevisiae)
- Pre-mrna-splicing factor cwc15 (19 kDa, Protein from Saccharomyces cerevisiae)
- U5 snrna (57 kDa, RNA from Saccharomyces cerevisiae)
- Pre-mrna-processing factor 17 (52 kDa, Protein from Saccharomyces cerevisiae)
- Small nuclear ribonucleoprotein-associated protein b (22 kDa, Protein from Saccharomyces cerevisiae)
- Magnesium ion (24 Da, Ligand)
- Small nuclear ribonucleoprotein sm d1 (16 kDa, Protein from Saccharomyces cerevisiae)
- Inositol hexakisphosphate (660 Da, Ligand)
- Pre-mrna-splicing factor cwc2 (38 kDa, Protein from Saccharomyces cerevisiae)
- Small nuclear ribonucleoprotein e (10 kDa, Protein from Saccharomyces cerevisiae)
- Pre-mrna-splicing factor 8 (279 kDa, Protein from Saccharomyces cerevisiae)
- Pre-mrna-splicing factor syf2 (24 kDa, Protein from Saccharomyces cerevisiae)
- Pre-mrna-splicing factor snu114 (114 kDa, Protein from Saccharomyces cerevisiae)
- Zinc ion (65 Da, Ligand)
- Saccharomyces cerevisiae strain t.52_2h chromosome xii sequence (35 kDa, RNA from Saccharomyces cerevisiae)
- Saccharomyces cerevisiae spliceosome. complex c just after prp16-mediated remodeling (Complex)
- Pre-mrna-splicing factor syf1 (101 kDa, Protein from Saccharomyces cerevisiae)
- Pre-mrna-splicing factor prp46 (50 kDa, Protein from Saccharomyces cerevisiae)
- Small nuclear ribonucleoprotein sm d2 (12 kDa, Protein from Saccharomyces cerevisiae)
Structure of a spliceosome remodeled for exon ligation
Resolution: 4.17 Å
EM Method: Single-particle
Fitted PDBs: 5mq0
Q-score: 0.223
Fica SM, Oubridge C, Galej WP, Wilkinson ME, Bai XC, Newman AJ, Nagai K
Nature (2017) 542 pp. 377-380 [ DOI: doi:10.1038/nature21078 Pubmed: 28076345 ]
- Small nuclear ribonucleoprotein f (9 kDa, Protein from Saccharomyces cerevisiae)
- Pre-mrna-splicing factor slu7 (44 kDa, Protein from Saccharomyces cerevisiae)
- Pre-mrna-splicing factor bud31 (18 kDa, Protein from Saccharomyces cerevisiae)
- Pre-mrna-splicing factor cef1 (67 kDa, Protein from Saccharomyces cerevisiae)
- Pre-mrna-splicing factor 18 (28 kDa, Protein from Saccharomyces cerevisiae)
- Unknown protein (5 kDa, Protein from Saccharomyces cerevisiae)
- Saccharomyces cerevisiae strain wi_c_mbsp_4 chromosome vii sequence (57 kDa, RNA from Saccharomyces cerevisiae)
- Pre-mrna-splicing factor slt11 (40 kDa, Protein from Saccharomyces cerevisiae)
- Pre-mrna-splicing factor cwc22 (67 kDa, Protein from Saccharomyces cerevisiae)
- Yeast ubc4 gene for ubiquitin-conjugating enzyme (30 kDa, RNA from Saccharomyces cerevisiae)
- U2 small nuclear ribonucleoprotein b'' (12 kDa, Protein from Saccharomyces cerevisiae)
- U2 small nuclear ribonucleoprotein a' (27 kDa, Protein from Saccharomyces cerevisiae)
- Small nuclear ribonucleoprotein sm d3 (11 kDa, Protein from Saccharomyces cerevisiae)
- Small nuclear ribonucleoprotein g (8 kDa, Protein from Saccharomyces cerevisiae)
- 3'-exon of ubc4 pre-mrna, bound by prp22 helicase (873 Da, RNA from Saccharomyces cerevisiae)
- Potassium ion (39 Da, Ligand)
- Pre-mrna-processing protein 45 (42 kDa, Protein from Saccharomyces cerevisiae)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Pre-mrna-splicing factor cwc21 (15 kDa, Protein from Saccharomyces cerevisiae)
- Pre-mrna-splicing factor clf1 (82 kDa, Protein from Saccharomyces cerevisiae)
- Pre-mrna-splicing factor cwc15 (19 kDa, Protein from Saccharomyces cerevisiae)
- Pre-mrna-splicing factor snt309 (20 kDa, Protein from Saccharomyces cerevisiae)
- Pre-mrna-processing factor 19 (56 kDa, Protein from Saccharomyces cerevisiae)
- Pre-mrna-processing factor 17 (52 kDa, Protein from Saccharomyces cerevisiae)
- Small nuclear ribonucleoprotein-associated protein b (22 kDa, Protein from Saccharomyces cerevisiae)
- Pre-mrna-splicing factor atp-dependent rna helicase prp22 (130 kDa, Protein from Saccharomyces cerevisiae)
- Magnesium ion (24 Da, Ligand)
- Small nuclear ribonucleoprotein sm d1 (16 kDa, Protein from Saccharomyces cerevisiae)
- Inositol hexakisphosphate (660 Da, Ligand)
- Pre-mrna-splicing factor cwc2 (38 kDa, Protein from Saccharomyces cerevisiae)
- Small nuclear ribonucleoprotein e (10 kDa, Protein from Saccharomyces cerevisiae)
- Pre-mrna-splicing factor 8 (279 kDa, Protein from Saccharomyces cerevisiae)
- Pre-mrna-splicing factor syf2 (24 kDa, Protein from Saccharomyces cerevisiae)
- Pre-mrna-splicing factor snu114 (114 kDa, Protein from Saccharomyces cerevisiae)
- Zinc ion (65 Da, Ligand)
- Saccharomyces cerevisiae strain t.52_2h chromosome xii sequence (35 kDa, RNA from Saccharomyces cerevisiae)
- Pre-mrna-splicing factor syf1,pre-mrna-splicing factor syf1 (101 kDa, Protein from Saccharomyces cerevisiae)
- Saccharomyces cerevisiae spliceosome. complex c just after prp16-mediated remodeling (Complex)
- S.cerevisiae chromosome ii reading frame orf ybr230c (376 kDa, RNA from Saccharomyces cerevisiae)
- 5'-exon of ubc4 pre-mrna (6 kDa, RNA from Saccharomyces cerevisiae)
- Pre-mrna-splicing factor prp46 (50 kDa, Protein from Saccharomyces cerevisiae)
- Small nuclear ribonucleoprotein sm d2 (12 kDa, Protein from Saccharomyces cerevisiae)
Structure of a spliceosome remodeled for exon ligation
Fica SM, Galej WP, Wilkinson ME, Oubridge C, Bai X-C, Newman AJ, Nagai K
Nature (2017) 542 pp. 377-380 [ DOI: doi:10.1038/nature21078 Pubmed: 28076345 ]
- Pre-mrna-splicing factor cwc22 (67 kDa, Protein from Baker's yeast)
- Small nuclear ribonucleoprotein g (8 kDa, Protein from Baker's yeast)
- Pre-mrna-processing protein 45 (42 kDa, Protein from Baker's yeast)
- Pre-mrna-splicing factor slt11 (40 kDa, Protein from Baker's yeast)
- Pre-mrna-splicing factor cwc15 (19 kDa, Protein from Baker's yeast)
- Pre-mrna-splicing factor clf1 (82 kDa, Protein from Baker's yeast)
- Pre-mrna-splicing factor 18 (28 kDa, Protein from Baker's yeast)
- Small nuclear ribonucleoprotein sm d1 (16 kDa, Protein from Baker's yeast)
- U2 small nuclear ribonucleoprotein a' (27 kDa, Protein from Baker's yeast)
- Pre-mrna-splicing factor slu7 (44 kDa, Protein from Baker's yeast)
- U2 small nuclear ribonucleoprotein b'' (12 kDa, Protein from Baker's yeast)
- Potassium ion (39 Da, Ligand)
- Small nuclear ribonucleoprotein sm d2 (12 kDa, Protein from Baker's yeast)
- Pre-mrna-splicing factor 8 (279 kDa, Protein from Baker's yeast)
- 3'exon of ubc4 pre-mrna bound to prp22 helicase (873 Da, RNA from Saccharomyces cerevisiae)
- Pre-mrna-splicing factor bud31 (18 kDa, Protein from Baker's yeast)
- Intron of ubc4 pre-mrna (30 kDa, RNA from Saccharomyces cerevisiae)
- Pre-mrna-splicing factor cwc21 (15 kDa, Protein from Baker's yeast)
- Pre-mrna-splicing factor snu114 (114 kDa, Protein from Baker's yeast)
- U6 snrna (35 kDa, RNA from Baker's yeast)
- Small nuclear ribonucleoprotein-associated protein b (22 kDa, Protein from Baker's yeast)
- Small nuclear ribonucleoprotein e (10 kDa, Protein from Baker's yeast)
- Pre-mrna-splicing factor prp46 (50 kDa, Protein from Baker's yeast)
- Pre-mrna-splicing factor atp-dependent rna helicase prp22 (130 kDa, Protein from Baker's yeast)
- Pre-mrna-splicing factor syf1 (100 kDa, Protein from Baker's yeast)
- Small nuclear ribonucleoprotein f (9 kDa, Protein from Baker's yeast)
- Magnesium ion (24 Da, Ligand)
- Pre-mrna-splicing factor syf2 (24 kDa, Protein from Baker's yeast)
- 5'exon of ubc4 pre-mrna (6 kDa, RNA from Saccharomyces cerevisiae)
- Zinc ion (65 Da, Ligand)
- Inositol hexakisphosphate (660 Da, Ligand)
- Pre-mrna-splicing factor cef1 (67 kDa, Protein from Baker's yeast)
- Pre-mrna-splicing factor cwc2 (38 kDa, Protein from Baker's yeast)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Unknown protein (5 kDa, Protein from Baker's yeast)
- U5 snrna (57 kDa, RNA from Baker's yeast)
- Saccharomyces cerevisiae spliceosome. complex c just after prp16-mediated remodeling (Complex)
- Small nuclear ribonucleoprotein sm d3 (11 kDa, Protein from Baker's yeast)
- Pre-mrna-processing factor 17 (52 kDa, Protein from Baker's yeast)
- U2 snrna (376 kDa, RNA from Baker's yeast)
The open state of the yeast U4/U6.U5 tri-snRNP at 4.2 Angstrom
Nguyen TH, Galej WP, Bai XC, Oubridge C, Newman AJ, Scheres SH, Nagai K
Nature (2016) 530 pp. 298-302 [ DOI: doi:10.1038/nature16940 Pubmed: 26829225 ]
- Smd2 (11 kDa, Protein from Saccharomyces cerevisiae)
- Brr2 (202 kDa, Protein from Saccharomyces cerevisiae)
- U5 snrna (45 kDa, RNA from Saccharomyces cerevisiae)
- Lsm3 (8 kDa, Protein from Saccharomyces cerevisiae)
- Lsm4 (8 kDa, Protein from Saccharomyces cerevisiae)
- Sme (8 kDa, Protein from Saccharomyces cerevisiae)
- Prp6 (84 kDa, Protein from Saccharomyces cerevisiae)
- U5 smd1 (9 kDa, Protein from Saccharomyces cerevisiae)
- Smb (9 kDa, Protein from Saccharomyces cerevisiae)
- Lsm7 (7 kDa, Protein from Saccharomyces cerevisiae)
- Prp4 (39 kDa, Protein from Saccharomyces cerevisiae)
- Smg (7 kDa, Protein from Saccharomyces cerevisiae)
- Smd3 (9 kDa, Protein from Saccharomyces cerevisiae)
- U6 snrna (25 kDa, RNA from Saccharomyces cerevisiae)
- Smf (8 kDa, Protein from Saccharomyces cerevisiae)
- U4 smd1 (10 kDa, Protein from Saccharomyces cerevisiae)
- Snu13 (13 kDa, Protein from Saccharomyces cerevisiae)
- Lsm6 (8 kDa, Protein from Saccharomyces cerevisiae)
- Dib1 (16 kDa, Protein from Saccharomyces cerevisiae)
- Snu66 (24 kDa, Protein from Saccharomyces cerevisiae)
- Tri-snrnp complex with 30 proteins and 3 snrna (1 MDa, Complex from Saccharomyces cerevisiae)
- Prp31 (47 kDa, Protein from Saccharomyces cerevisiae)
- Lsm2 (10 kDa, Protein from Saccharomyces cerevisiae)
- Snu114 (97 kDa, Protein from Saccharomyces cerevisiae)
- U4 snrna (39 kDa, RNA from Saccharomyces cerevisiae)
- Prp8 (255 kDa, Protein from Saccharomyces cerevisiae)
- Lsm5 (8 kDa, Protein from Saccharomyces cerevisiae)
- Unknown proteins (8 kDa, Protein from Saccharomyces cerevisiae)
- Lsm8 (7 kDa, Protein from Saccharomyces cerevisiae)
- U5 sme (8 kDa, Protein from Saccharomyces cerevisiae)
- Prp3 (37 kDa, Protein from Saccharomyces cerevisiae)
The closed state of the yeast spliceosomal U4/U6.U5 tri-snRNP at 4.3 Angstrom
Nguyen TH, Galej WP, Bai XC, Oubridge C, Newman AJ, Scheres SH, Nagai K
Nature (2016) 530 pp. 298-302 [ DOI: doi:10.1038/nature16940 Pubmed: 26829225 ]
- Smd2 (11 kDa, Protein from Saccharomyces cerevisiae)
- Brr2 (202 kDa, Protein from Saccharomyces cerevisiae)
- U5 snrna (45 kDa, RNA from Saccharomyces cerevisiae)
- Lsm3 (8 kDa, Protein from Saccharomyces cerevisiae)
- Lsm4 (8 kDa, Protein from Saccharomyces cerevisiae)
- Sme (8 kDa, Protein from Saccharomyces cerevisiae)
- Prp6 (84 kDa, Protein from Saccharomyces cerevisiae)
- U5 smd1 (9 kDa, Protein from Saccharomyces cerevisiae)
- Smb (9 kDa, Protein from Saccharomyces cerevisiae)
- Lsm7 (7 kDa, Protein from Saccharomyces cerevisiae)
- Prp4 (39 kDa, Protein from Saccharomyces cerevisiae)
- Smg (7 kDa, Protein from Saccharomyces cerevisiae)
- Smd3 (9 kDa, Protein from Saccharomyces cerevisiae)
- U6 snrna (25 kDa, RNA from Saccharomyces cerevisiae)
- Smf (8 kDa, Protein from Saccharomyces cerevisiae)
- U4 smd1 (10 kDa, Protein from Saccharomyces cerevisiae)
- Snu13 (13 kDa, Protein from Saccharomyces cerevisiae)
- Lsm6 (8 kDa, Protein from Saccharomyces cerevisiae)
- Dib1 (16 kDa, Protein from Saccharomyces cerevisiae)
- Snu66 (24 kDa, Protein from Saccharomyces cerevisiae)
- Tri-snrnp complex with 30 proteins and 3 snrna (1 MDa, Complex from Saccharomyces cerevisiae)
- Prp31 (47 kDa, Protein from Saccharomyces cerevisiae)
- Lsm2 (10 kDa, Protein from Saccharomyces cerevisiae)
- Snu114 (97 kDa, Protein from Saccharomyces cerevisiae)
- U4 snrna (39 kDa, RNA from Saccharomyces cerevisiae)
- Prp8 (255 kDa, Protein from Saccharomyces cerevisiae)
- Lsm5 (8 kDa, Protein from Saccharomyces cerevisiae)
- Unknown proteins (8 kDa, Protein from Saccharomyces cerevisiae)
- Lsm8 (7 kDa, Protein from Saccharomyces cerevisiae)
- U5 sme (8 kDa, Protein from Saccharomyces cerevisiae)
- Prp3 (37 kDa, Protein from Saccharomyces cerevisiae)
Nguyen TH, Galej WP, Bai XC, Oubridge C, Newman AJ, Scheres SH, Nagai K
Nature (2016) 530 pp. 298-302 [ DOI: doi:10.1038/nature16940 Pubmed: 26829225 ]
- Smd2 (11 kDa, Protein from Saccharomyces cerevisiae)
- Brr2 (202 kDa, Protein from Saccharomyces cerevisiae)
- U5 snrna (45 kDa, RNA from Saccharomyces cerevisiae)
- Lsm3 (8 kDa, Protein from Saccharomyces cerevisiae)
- Lsm4 (8 kDa, Protein from Saccharomyces cerevisiae)
- Sme (8 kDa, Protein from Saccharomyces cerevisiae)
- Prp6 (84 kDa, Protein from Saccharomyces cerevisiae)
- U5 smd1 (9 kDa, Protein from Saccharomyces cerevisiae)
- Smb (9 kDa, Protein from Saccharomyces cerevisiae)
- Lsm7 (7 kDa, Protein from Saccharomyces cerevisiae)
- Prp4 (39 kDa, Protein from Saccharomyces cerevisiae)
- Smg (7 kDa, Protein from Saccharomyces cerevisiae)
- Smd3 (9 kDa, Protein from Saccharomyces cerevisiae)
- U6 snrna (25 kDa, RNA from Saccharomyces cerevisiae)
- Smf (8 kDa, Protein from Saccharomyces cerevisiae)
- U4 smd1 (10 kDa, Protein from Saccharomyces cerevisiae)
- Snu13 (13 kDa, Protein from Saccharomyces cerevisiae)
- Lsm6 (8 kDa, Protein from Saccharomyces cerevisiae)
- Dib1 (16 kDa, Protein from Saccharomyces cerevisiae)
- Snu66 (24 kDa, Protein from Saccharomyces cerevisiae)
- Tri-snrnp complex with 30 proteins and 3 snrna (1 MDa, Complex from Saccharomyces cerevisiae)
- Prp31 (47 kDa, Protein from Saccharomyces cerevisiae)
- Lsm2 (10 kDa, Protein from Saccharomyces cerevisiae)
- Snu114 (97 kDa, Protein from Saccharomyces cerevisiae)
- U4 snrna (39 kDa, RNA from Saccharomyces cerevisiae)
- Prp8 (255 kDa, Protein from Saccharomyces cerevisiae)
- Lsm5 (8 kDa, Protein from Saccharomyces cerevisiae)
- Unknown proteins (8 kDa, Protein from Saccharomyces cerevisiae)
- Lsm8 (7 kDa, Protein from Saccharomyces cerevisiae)
- U5 sme (8 kDa, Protein from Saccharomyces cerevisiae)
- Prp3 (37 kDa, Protein from Saccharomyces cerevisiae)
Nguyen TH, Galej WP, Bai XC, Oubridge C, Newman AJ, Scheres SH, Nagai K
Nature (2016) 530 pp. 298-302 [ DOI: doi:10.1038/nature16940 Pubmed: 26829225 ]
- Smd2 (11 kDa, Protein from Saccharomyces cerevisiae)
- Brr2 (202 kDa, Protein from Saccharomyces cerevisiae)
- U5 snrna (45 kDa, RNA from Saccharomyces cerevisiae)
- Lsm3 (8 kDa, Protein from Saccharomyces cerevisiae)
- Lsm4 (8 kDa, Protein from Saccharomyces cerevisiae)
- Sme (8 kDa, Protein from Saccharomyces cerevisiae)
- Prp6 (84 kDa, Protein from Saccharomyces cerevisiae)
- U5 smd1 (9 kDa, Protein from Saccharomyces cerevisiae)
- Smb (9 kDa, Protein from Saccharomyces cerevisiae)
- Lsm7 (7 kDa, Protein from Saccharomyces cerevisiae)
- Prp4 (39 kDa, Protein from Saccharomyces cerevisiae)
- Smg (7 kDa, Protein from Saccharomyces cerevisiae)
- Smd3 (9 kDa, Protein from Saccharomyces cerevisiae)
- U6 snrna (25 kDa, RNA from Saccharomyces cerevisiae)
- Smf (8 kDa, Protein from Saccharomyces cerevisiae)
- U4 smd1 (10 kDa, Protein from Saccharomyces cerevisiae)
- Snu13 (13 kDa, Protein from Saccharomyces cerevisiae)
- Lsm6 (8 kDa, Protein from Saccharomyces cerevisiae)
- Dib1 (16 kDa, Protein from Saccharomyces cerevisiae)
- Snu66 (24 kDa, Protein from Saccharomyces cerevisiae)
- Tri-snrnp complex with 30 proteins and 3 snrna (1 MDa, Complex from Saccharomyces cerevisiae)
- Prp31 (47 kDa, Protein from Saccharomyces cerevisiae)
- Lsm2 (10 kDa, Protein from Saccharomyces cerevisiae)
- Snu114 (97 kDa, Protein from Saccharomyces cerevisiae)
- U4 snrna (39 kDa, RNA from Saccharomyces cerevisiae)
- Prp8 (255 kDa, Protein from Saccharomyces cerevisiae)
- Lsm5 (8 kDa, Protein from Saccharomyces cerevisiae)
- Unknown proteins (8 kDa, Protein from Saccharomyces cerevisiae)
- Lsm8 (7 kDa, Protein from Saccharomyces cerevisiae)
- U5 sme (8 kDa, Protein from Saccharomyces cerevisiae)
- Prp3 (37 kDa, Protein from Saccharomyces cerevisiae)
Nguyen TH, Galej WP, Bai XC, Oubridge C, Newman AJ, Scheres SH, Nagai K
Nature (2016) 530 pp. 298-302 [ DOI: doi:10.1038/nature16940 Pubmed: 26829225 ]
- Smd2 (11 kDa, Protein from Saccharomyces cerevisiae)
- Brr2 (202 kDa, Protein from Saccharomyces cerevisiae)
- U5 snrna (45 kDa, RNA from Saccharomyces cerevisiae)
- Lsm3 (8 kDa, Protein from Saccharomyces cerevisiae)
- Lsm4 (8 kDa, Protein from Saccharomyces cerevisiae)
- Sme (8 kDa, Protein from Saccharomyces cerevisiae)
- Prp6 (84 kDa, Protein from Saccharomyces cerevisiae)
- U5 smd1 (9 kDa, Protein from Saccharomyces cerevisiae)
- Smb (9 kDa, Protein from Saccharomyces cerevisiae)
- Lsm7 (7 kDa, Protein from Saccharomyces cerevisiae)
- Prp4 (39 kDa, Protein from Saccharomyces cerevisiae)
- Smg (7 kDa, Protein from Saccharomyces cerevisiae)
- Smd3 (9 kDa, Protein from Saccharomyces cerevisiae)
- U6 snrna (25 kDa, RNA from Saccharomyces cerevisiae)
- Smf (8 kDa, Protein from Saccharomyces cerevisiae)
- U4 smd1 (10 kDa, Protein from Saccharomyces cerevisiae)
- Snu13 (13 kDa, Protein from Saccharomyces cerevisiae)
- Lsm6 (8 kDa, Protein from Saccharomyces cerevisiae)
- Dib1 (16 kDa, Protein from Saccharomyces cerevisiae)
- Snu66 (24 kDa, Protein from Saccharomyces cerevisiae)
- Tri-snrnp complex with 30 proteins and 3 snrna (1 MDa, Complex from Saccharomyces cerevisiae)
- Prp31 (47 kDa, Protein from Saccharomyces cerevisiae)
- Lsm2 (10 kDa, Protein from Saccharomyces cerevisiae)
- Snu114 (97 kDa, Protein from Saccharomyces cerevisiae)
- U4 snrna (39 kDa, RNA from Saccharomyces cerevisiae)
- Prp8 (255 kDa, Protein from Saccharomyces cerevisiae)
- Lsm5 (8 kDa, Protein from Saccharomyces cerevisiae)
- Unknown proteins (8 kDa, Protein from Saccharomyces cerevisiae)
- Lsm8 (7 kDa, Protein from Saccharomyces cerevisiae)
- U5 sme (8 kDa, Protein from Saccharomyces cerevisiae)
- Prp3 (37 kDa, Protein from Saccharomyces cerevisiae)
Foot region of the yeast spliceosomal U4/U6.U5 tri-snRNP
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 5gam
Q-score: 0.363
Nguyen THD, Galej WP, Bai XC, Oubridge C, Scheres SHW, Newman AJ, Nagai K
Nature (2016) 530 pp. 298-302 [ DOI: doi:10.1038/nature16940 Pubmed: 26829225 ]
- Small nuclear ribonucleoprotein f (9 kDa, Protein from Saccharomyces cerevisiae)
- Small nuclear ribonucleoprotein sm d2 (12 kDa, Protein from Saccharomyces cerevisiae)
- U6 snrna, 5' end (9 kDa, RNA from Saccharomyces cerevisiae)
- Small nuclear ribonucleoprotein g (8 kDa, Protein from Saccharomyces cerevisiae)
- Unknown polypeptide (1 kDa, Protein from Saccharomyces cerevisiae)
- Foot region of the yeast spliceosomal u4/u6.u5 tri-snrnp (350 kDa, Complex from Saccharomyces cerevisiae)
- Small nuclear ribonucleoprotein-associated protein b (22 kDa, Protein from Saccharomyces cerevisiae)
- Small nuclear ribonucleoprotein sm d3 (11 kDa, Protein from Saccharomyces cerevisiae)
- Pre-mrna-splicing factor 8 (85 kDa, Protein from Saccharomyces cerevisiae)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Pre-mrna-splicing factor snu114 (114 kDa, Protein from Saccharomyces cerevisiae)
- U5 snrna (57 kDa, RNA from Saccharomyces cerevisiae)
- Small nuclear ribonucleoprotein sm d1 (16 kDa, Protein from Saccharomyces cerevisiae)
- Small nuclear ribonucleoprotein e (10 kDa, Protein from Saccharomyces cerevisiae)
The overall structure of the yeast spliceosomal U4/U6.U5 tri-snRNP at 3.7 Angstrom
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 5gan
Q-score: 0.254
Nguyen TH, Galej WP, Bai XC, Oubridge C, Newman AJ, Scheres SH, Nagai K
Nature (2016) 530 pp. 298-302 [ DOI: doi:10.1038/nature16940 Pubmed: 26829225 ]
- Pre-mrna-splicing factor 6 (104 kDa, Protein from Saccharomyces cerevisiae)
- Small nuclear ribonucleoprotein f (9 kDa, Protein from Saccharomyces cerevisiae)
- U6 snrna-associated sm-like protein lsm7 (13 kDa, Protein from Saccharomyces cerevisiae)
- U5 snrna (68 kDa, RNA from Saccharomyces cerevisiae)
- Small nuclear ribonucleoprotein sm d3 (11 kDa, Protein from Saccharomyces cerevisiae)
- Small nuclear ribonucleoprotein g (8 kDa, Protein from Saccharomyces cerevisiae)
- U4/u6 small nuclear ribonucleoprotein prp3 (55 kDa, Protein from Saccharomyces cerevisiae)
- U6 snrna (35 kDa, RNA from Saccharomyces cerevisiae)
- Pre-mrna-processing factor 31 (56 kDa, Protein from Saccharomyces cerevisiae)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- U4/u6 small nuclear ribonucleoprotein prp4 (52 kDa, Protein from Saccharomyces cerevisiae)
- Unknown protein (8 kDa, Protein from Saccharomyces cerevisiae)
- U6 snrna-associated sm-like protein lsm6 (9 kDa, Protein from Saccharomyces cerevisiae)
- Pre-mrna-splicing helicase brr2 (246 kDa, Protein from Saccharomyces cerevisiae)
- Small nuclear ribonucleoprotein-associated protein b (22 kDa, Protein from Saccharomyces cerevisiae)
- 13 kda ribonucleoprotein-associated protein (13 kDa, Protein from Saccharomyces cerevisiae)
- Spliceosomal protein dib1 (16 kDa, Protein from Saccharomyces cerevisiae)
- Pre-mrna-splicing factor snu114 (114 kDa, Protein from Saccharomyces cerevisiae)
- Small nuclear ribonucleoprotein sm d1 (16 kDa, Protein from Saccharomyces cerevisiae)
- U6 snrna-associated sm-like protein lsm3 (10 kDa, Protein from Saccharomyces cerevisiae)
- Small nuclear ribonucleoprotein e (10 kDa, Protein from Saccharomyces cerevisiae)
- Pre-mrna-splicing factor 8 (279 kDa, Protein from Saccharomyces cerevisiae)
- Snu66 (28 kDa, Protein from Saccharomyces cerevisiae)
- U6 snrna-associated sm-like protein lsm4 (21 kDa, Protein from Saccharomyces cerevisiae)
- U6 snrna-associated sm-like protein lsm8 (12 kDa, Protein from Saccharomyces cerevisiae)
- The overall structure of the yeast spliceosomal u4/u6.u5 tri-snrnp (1 MDa, Complex from Saccharomyces cerevisiae)
- U4 snrna (51 kDa, RNA from Saccharomyces cerevisiae)
- U6 snrna-associated sm-like protein lsm5 (10 kDa, Protein from Saccharomyces cerevisiae)
- Small nuclear ribonucleoprotein sm d2 (12 kDa, Protein from Saccharomyces cerevisiae)
- U6 snrna-associated sm-like protein lsm2 (11 kDa, Protein from Saccharomyces cerevisiae)