Cryo-EM structure of STING oligomer bound to cGAMP and NVS-STG2
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 8flk
Q-score: 0.438
Li J, Canham SM, Wu H, Henault M, Chen L, Liu G, Chen Y, Yu G, Miller HR, Hornak V, Brittain SM, Michaud GA, Tutter A, Broom W, Digan ME, McWhirter SM, Sivick KE, Pham HT, Chen CH, Tria GS, McKenna JM, Schirle M, Mao X, Nicholson TB, Wang Y, Jenkins JL, Jain RK, Tallarico JA, Patel SJ, Zheng L, Ross NT, Cho CY, Zhang X, Bai XC, Feng Y
Nat Chem Biol (2024) 20 pp. 365-372 [ Pubmed: 37828400 DOI: doi:10.1038/s41589-023-01434-y ]
- 4-({[4-(2-tert-butyl-5,5-dimethyl-1,3-dioxan-2-yl)phenyl]methyl}amino)-3-methoxybenzoic acid (427 Da, Ligand)
- Cgamp (674 Da, Ligand)
- Stimulator of interferon genes protein (39 kDa, Protein from Homo sapiens)
- Sting tetramer (300 kDa, Complex from Homo sapiens)
Cryo-EM structure of STING oligomer bound to cGAMP, NVS-STG2 and C53
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8flm
Q-score: 0.573
Li J, Canham SM, Wu H, Henault M, Chen L, Liu G, Chen Y, Yu G, Miller HR, Hornak V, Brittain SM, Michaud GA, Tutter A, Broom W, Digan ME, McWhirter SM, Sivick KE, Pham HT, Chen CH, Tria GS, McKenna JM, Schirle M, Mao X, Nicholson TB, Wang Y, Jenkins JL, Jain RK, Tallarico JA, Patel SJ, Zheng L, Ross NT, Cho CY, Zhang X, Bai XC, Feng Y
Nat Chem Biol (2024) 20 pp. 365-372 [ Pubmed: 37828400 DOI: doi:10.1038/s41589-023-01434-y ]
- 4-({[4-(2-tert-butyl-5,5-dimethyl-1,3-dioxan-2-yl)phenyl]methyl}amino)-3-methoxybenzoic acid (427 Da, Ligand)
- Stimulator of interferon genes protein (39 kDa, Protein from Homo sapiens)
- Sting tetramer (300 kDa, Complex from Homo sapiens)
- Cgamp (674 Da, Ligand)
- 1-[(2-chloro-6-fluorophenyl)methyl]-3,3-dimethyl-2-oxo-n-[(2,4,6-trifluorophenyl)methyl]-2,3-dihydro-1h-indole-6-carboxamide (490 Da, Ligand)
Atomic structure of the Apaf-1 apoptosome
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 3jbt
Q-score: 0.201
Zhou MY, Li YN, Hu Q, Bai XC, Huang WY, Yan CY, Scheres SHW, Shi YG
Genes Dev (2015) [ Pubmed: 26543158 DOI: doi:10.1101/gad.272278.115 ]
Atomic structure of the Apaf-1 apoptosome
Resolution: 4.4 Å
EM Method: Single-particle
Fitted PDBs: 3jbt
Q-score: 0.128
Zhou MY, Li YN, Hu Q, Bai XC, Huang WY, Yan CY, Scheres SHW, Shi YG
Genes Dev (2015) [ Pubmed: 26543158 DOI: doi:10.1101/gad.272278.115 ]
Cryo-EM structure of the human gamma-secretase complex at 3.4 angstrom resolution.
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 5a63
Q-score: 0.457
Bai XC, Yan CY, Yang GH, Lu PL, Ma D, Sun LF, Zhou R, Scheres SHW, Shi YG
Nature (2015) 525 pp. 212-217 [ DOI: doi:10.1038/NATURE14892 Pubmed: 26280335 ]
- Human gamma-secretase (170 kDa, Sample)
- Gamma-secretase (170 kDa, Protein from Homo sapiens)
Cryo-EM structure of the multimeric complex between Dark and Dronc-CARD.
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 3j9k
Q-score: 0.234
Pang Y, Bai XC, Yan C, Hao Q, Chen Z, Wang JW, Scheres SH, Shi Y
Genes Dev (2015) 29 pp. 277-287 [ Pubmed: 25644603 DOI: doi:10.1101/gad.255877.114 ]
- Dark apoptosome in complex with dronc-card. (3 MDa, Sample)
- Dark apoptosome (3 MDa, Protein from Drosophila melanogaster)
- Dronc-card (Protein from Drosophila melanogaster)
Cryo-EM structure of the Dark apoptosome.
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 3j9l
Q-score: 0.206
Pang Y, Bai XC, Yan C, Hao Q, Chen Z, Wang JW, Scheres SH, Shi Y
Genes Dev (2015) 29 pp. 277-287 [ Pubmed: 25644603 DOI: doi:10.1101/gad.255877.114 ]
- Dark apoptosome (2 MDa, Sample)
- Dark apoptosome (2 MDa, Protein from Drosophila melanogaster)
Single-particle electron cryo-microscopy structure of ryanodine receptor RyR1 in complex with FKBP12
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 3j8h
Q-score: 0.338
Yan Z, Bai XC, Yan C, Wu J, Li Z, Xie T, Peng W, Yin CC, Li X, Scheres SH, Shi Y, Yan N
Nature (2015) 517 pp. 50-55 [ DOI: doi:10.1038/nature14063 Pubmed: 25517095 ]
- Ryanodine receptor ryr1 (5 MDa, Protein from Oryctolagus cuniculus)
- Rabbit ryr1 in complex with its modulator fkbp12 (5 MDa, Sample)
Three-dimensional structure of human gamma-secretase at 4.5 angstrom resolution
Lu PL, Bai XC, Ma D, Xie T, Yan CY, Sun LF, Yang GH, Zhao YY, Zhou R, Scheres SHW, Shi YG
Nature (2014) 512 pp. 166-170 [ DOI: doi:10.1038/nature13567 Pubmed: 25043039 ]
- Human gamma-secretase (170 kDa, Protein from Homo sapiens)
- Human gamma-secretase (170 kDa, Sample)
Three-dimensional structure of human gamma-secretase at 5.4 angstrom resoltuion
Lu PL, Bai XC, Ma D, Xie T, Yan CY, Sun LF, Yang GH, Zhao YY, Zhou R, Scheres SHW, Shi YG
Nature (2014) 512 pp. 166-170 [ Pubmed: 25043039 DOI: doi:10.1038/NATURE13567 ]
- Human gamma-secretase (170 kDa, Sample)
- Gamma-secretase (170 kDa, Protein from Homo sapiens)