human KCC1 structure determined in KCl and detergent GDN
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 6kkr
Q-score: 0.559
Liu S, Chang S, Han B, Xu L, Zhang M, Zhao C, Yang W, Wang F, Li J, Delpire E, Ye S, Bai XC, Guo J
Science (2019) 366 pp. 505-508 [ Pubmed: 31649201 DOI: doi:10.1126/science.aay3129 ]
- Potassium ion (39 Da, Ligand)
- Solute carrier family 12 member 4 (122 kDa, Protein from Homo sapiens)
- Potassium chloride co-transporter 1 (Complex from Homo sapiens)
- 2-[2-[(1~{s},2~{s},4~{s},5'~{r},6~{r},7~{s},8~{r},9~{s},12~{s},13~{r},16~{s})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxyethyl]propane-1,3-diol (516 Da, Ligand)
- Chloride ion (35 Da, Ligand)
human KCC1 structure determined in KCl and lipid nanodisc
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 6kkt
Q-score: 0.559
Liu S, Chang S, Han B, Xu L, Zhang M, Zhao C, Yang W, Wang F, Li J, Delpire E, Ye S, Bai XC, Guo J
Science (2019) 366 pp. 505-508 [ Pubmed: 31649201 DOI: doi:10.1126/science.aay3129 ]
- Potassium ion (39 Da, Ligand)
- Solute carrier family 12 member 4 (122 kDa, Protein from Homo sapiens)
- Potassium chloride co-transporter 1 (Complex from Homo sapiens)
- 2-[2-[(1~{s},2~{s},4~{s},5'~{r},6~{r},7~{s},8~{r},9~{s},12~{s},13~{r},16~{s})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxyethyl]propane-1,3-diol (516 Da, Ligand)
- Chloride ion (35 Da, Ligand)
human KCC1 structure determined in NaCl and GDN
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 6kku
Q-score: 0.469
Liu S, Chang S, Han B, Xu L, Zhang M, Zhao C, Yang W, Wang F, Li J, Delpire E, Ye S, Bai XC, Guo J
Science (2019) 366 pp. 505-508 [ Pubmed: 31649201 DOI: doi:10.1126/science.aay3129 ]
- 2-[2-[(1~{s},2~{s},4~{s},5'~{r},6~{r},7~{s},8~{r},9~{s},12~{s},13~{r},16~{s})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxyethyl]propane-1,3-diol (516 Da, Ligand)
- Potassium chloride co-transporter 1 (Complex from Homo sapiens)
- Solute carrier family 12 member 4 (122 kDa, Protein from Homo sapiens)
- Chloride ion (35 Da, Ligand)
Cryo-EM structure of human TPC2 channel in the ligand-bound open state
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 6nq0
Q-score: 0.455
Cryo-EM structure of human TPC2 channel in the apo state
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 6nq1
Q-score: 0.441
She J, Zeng W, Guo J, Chen Q, Bai X, Jiang Y
eLife (2019) 8 [ DOI: doi:10.7554/eLife.45222 Pubmed: 30860481 ]
- Two-pore channel 2 (Complex from Homo sapiens)
- Two pore calcium channel protein 2 (85 kDa, Protein from Homo sapiens)
Cryo-EM structure of human TPC2 channel in the ligand-bound closed state
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 6nq2
Q-score: 0.491
She J, Zeng W, Guo J, Chen Q, Bai X, Jiang Y
eLife (2019) 8 [ DOI: doi:10.7554/eLife.45222 Pubmed: 30860481 ]
- Two pore calcium channel protein 2 (85 kDa, Protein from Homo sapiens)
- The complex of two-pore channel 2 with pi(3,5)p2 (Complex from Homo sapiens)
- (2r)-3-{[(s)-hydroxy{[(1s,2r,3r,4s,5s,6r)-2,4,6-trihydroxy-3,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctanoate (746 Da, Ligand)
Cryo-EM structure of mouse TPC1 channel in the apo state
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 6c96
Q-score: 0.456
She J, Guo J, Chen Q, Zeng W, Jiang Y, Bai XC
Nature (2018) 556 pp. 130-134 [ Pubmed: 29562233 DOI: doi:10.1038/nature26139 ]
- Sodium ion (22 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Apo mouse tpc1 (Cellular component from Mus musculus)
- Two pore calcium channel protein 1 (95 kDa, Protein from Mus musculus)
Cryo-EM structure of mouse TPC1 channel in the PtdIns(3,5)P2-bound state
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 6c9a
Q-score: 0.49
She J, Guo J, Chen Q, Zeng W, Jiang Y, Bai XC
Nature (2018) 556 pp. 130-134 [ Pubmed: 29562233 DOI: doi:10.1038/nature26139 ]
- Ptdins(3,5)p2-bound mouse tpc1 (Cellular component from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- (2r)-3-{[(s)-hydroxy{[(1s,2r,3r,4s,5s,6r)-2,4,6-trihydroxy-3,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctanoate (746 Da, Ligand)
- Two pore calcium channel protein 1 (95 kDa, Protein from Mus musculus)
cryo-EM structure of TRPM4 in apo state with short coiled coil at 3.1 angstrom resolution
Resolution: 3.14 Å
EM Method: Single-particle
Fitted PDBs: 6bcj
Q-score: 0.502
Guo J, She J, Zeng W, Chen Q, Bai XC, Jiang Y
Nature (2017) 552 pp. 205-209 [ Pubmed: 29211714 DOI: doi:10.1038/nature24997 ]
- Homotetramer of mouse trpm4 (Complex from Mus musculus)
- Sodium ion (22 Da, Ligand)
- Water (18 Da, Ligand)
- Transient receptor potential cation channel subfamily m member 4 (140 kDa, Protein from Mus musculus)
cryo-EM structure of TRPM4 in apo state with long coiled coil at 3.5 angstrom resolution
Resolution: 3.54 Å
EM Method: Single-particle
Fitted PDBs: 6bcl
Q-score: 0.43
Guo J, She J, Zeng W, Chen Q, Bai XC, Jiang Y
Nature (2017) 552 pp. 205-209 [ Pubmed: 29211714 DOI: doi:10.1038/nature24997 ]
- Homotetramer of mouse trpm4 (Complex from Mus musculus)
- Sodium ion (22 Da, Ligand)
- Transient receptor potential cation channel subfamily m member 4 (140 kDa, Protein from Mus musculus)