Local refined map of VPS35L(partial)-VPS26C-SNX17
Singla A, Boesch DJ, Fung HYJ, Ngoka C, Enriquez AS, Song R, Kramer DA, Han Y, Banarer E, Lemoff A, Juneja P, Billadeau DD, Bai X, Chen Z, Turer EE, Burstein E, Chen B
Nat Commun (2024) 15 pp. 10193-10193 [ DOI: doi:10.1038/s41467-024-54583-6 Pubmed: 39587083 ]
Local refined map of VPS35L(partial)-VPS29
Singla A, Boesch DJ, Fung HYJ, Ngoka C, Enriquez AS, Song R, Kramer DA, Han Y, Banarer E, Lemoff A, Juneja P, Billadeau DD, Bai X, Chen Z, Turer EE, Burstein E, Chen B
Nat Commun (2024) 15 pp. 10193-10193 [ DOI: doi:10.1038/s41467-024-54583-6 Pubmed: 39587083 ]
Human Retriever VPS35L/VPS29/VPS26C complex bound to SNX17 peptide (Composite Map)
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 9au7
Q-score: 0.202
Singla A, Boesch DJ, Fung HYJ, Ngoka C, Enriquez AS, Song R, Kramer DA, Han Y, Banarer E, Lemoff A, Juneja P, Billadeau DD, Bai X, Chen Z, Turer EE, Burstein E, Chen B
Nat Commun (2024) 15 pp. 10193-10193 [ DOI: doi:10.1038/s41467-024-54583-6 Pubmed: 39587083 ]
- Sorting nexin-17 (2 kDa, Protein from Homo sapiens)
- Vacuolar protein sorting-associated protein 26c (33 kDa, Protein from Homo sapiens)
- Trimeric complex of vps35/vps29/vps26 with excess snx17 peptide (Complex from Homo sapiens)
- Vacuolar protein sorting-associated protein 29 (23 kDa, Protein from Homo sapiens)
- Vps35 endosomal protein-sorting factor-like (109 kDa, Protein from Homo sapiens)
Human Retriever VPS35L/VPS29/VPS26C complex bound to SNX17 peptide (Consensus map)
Singla A, Boesch DJ, Fung HYJ, Ngoka C, Enriquez AS, Song R, Kramer DA, Han Y, Banarer E, Lemoff A, Juneja P, Billadeau DD, Bai X, Chen Z, Turer EE, Burstein E, Chen B
Nat Commun (2024) 15 pp. 10193-10193 [ DOI: doi:10.1038/s41467-024-54583-6 Pubmed: 39587083 ]
- Sorting nexin-17 (Protein from Homo sapiens)
- Trimeric complex of vps35/vps29/vps26 with excess snx17 peptide (Complex from Homo sapiens)
- Vacuolar protein sorting-associated protein 26c (Protein from Homo sapiens)
- Vps35 endosomal protein-sorting factor-like (Protein from Homo sapiens)
- Vacuolar protein sorting-associated protein 29 (Protein from Homo sapiens)
Cryo-EM structure of spike binding to Fab of neutralizing antibody (locally refined)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8dt3
Q-score: 0.458
Fang Y, Sun P, Xie X, Du M, Du F, Ye J, Kalveram BK, Plante JA, Plante KS, Li B, Bai XC, Shi PY, Chen ZJ
Sci Immunol (2022) 7 pp. eabp9962-eabp9962 [ DOI: doi:10.1126/sciimmunol.abp9962 Pubmed: 35926067 ]
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Light chain fab of sw186 (25 kDa, Protein from Mus musculus)
- Rbd-sd1 of spike in complex with fab from a neutralizing antibody (Complex from Mus musculus)
- Heavy chain fab of sw186 (24 kDa, Protein from Mus musculus)
Molecular mechanism of the the wake-promoting agent TAK-925
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7sr8
Q-score: 0.457
Yin J, Kang Y, McGrath AP, Chapman K, Sjodt M, Kimura E, Okabe A, Koike T, Miyanohana Y, Shimizu Y, Rallabandi R, Lian P, Bai X, Flinspach M, De Brabander JK, Rosenbaum DM
Nat Commun (2022) 13 pp. 2902-2902 [ Pubmed: 35614071 DOI: doi:10.1038/s41467-022-30601-3 ]
- A modified guanine nucleotide-binding protein g(q) subunit alpha (27 kDa, Protein from Homo sapiens)
- Scfv16 (27 kDa, Protein from Homo sapiens)
- Oleic acid (282 Da, Ligand)
- Human orexin receptor 2 - g protein complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Hypocretin receptor type 2 (46 kDa, Protein from Homo sapiens)
- Methyl (2r,3s)-3-[(methanesulfonyl)amino]-2-({[(1s,4s)-4-phenylcyclohexyl]oxy}methyl)piperidine-1-carboxylate (424 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (9 kDa, Protein from Homo sapiens)
Structure of the orexin-2 receptor (OX2R) bound to TAK-925, Gi and scFv16
Resolution: 3.17 Å
EM Method: Single-particle
Fitted PDBs: 7sqo
Q-score: 0.487
Yin J, Kang Y, McGrath AP, Chapman K, Sjodt M, Kimura E, Okabe A, Koike T, Miyanohana Y, Shimizu Y, Rallabandi R, Lian P, Bai X, Flinspach M, De Brabander JK, Rosenbaum DM
Nat Commun (2022) 13 pp. 2902-2902 [ Pubmed: 35614071 DOI: doi:10.1038/s41467-022-30601-3 ]
- Orexin receptor type 2 (Complex from Homo sapiens)
- Human ox2r in complex with gai/gb/gg-scfv16. (Complex)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Oleic acid (282 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Bos taurus)
- Scfv-16 (26 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (Complex from Homo sapiens)
- Methyl (2r,3s)-3-[(methanesulfonyl)amino]-2-({[(1s,4s)-4-phenylcyclohexyl]oxy}methyl)piperidine-1-carboxylate (424 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Orexin receptor type 2 (50 kDa, Protein from Homo sapiens)
- Scfv-16 (Complex from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1, guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from Bos taurus)
Structure of a D2 dopamine receptor-G-protein complex in a lipid membrane
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 6vms
Q-score: 0.38
Yin J, Chen KM, Clark MJ, Hijazi M, Kumari P, Bai XC, Sunahara RK, Barth P, Rosenbaum DM
Nature (2020) 584 pp. 125-129 [ Pubmed: 32528175 DOI: doi:10.1038/s41586-020-2379-5 ]
- D2 dopamine receptor-g protein complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Rattus norvegicus)
- Scfv16 (27 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Endolysin,d(2) dopamine receptor,d(2) dopamine receptor (51 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (9 kDa, Protein from Homo sapiens)
- Bromoergocryptine (654 Da, Ligand)
Cryo-EM structure of the mitochondrial calcium uniporter from N. fischeri at 3.8 Angstrom resolution
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 6d7w
Q-score: 0.398
Nguyen NX, Armache J-P, Lee C, Yang Y, Zeng W, Mootha VK, Cheng Y, Bai XC, Jiang Y
Nature (2018) 559 pp. 570-574 [ Pubmed: 29995855 DOI: doi:10.1038/s41586-018-0333-6 ]
- Mitochondrial calcium uniporter (47 kDa, Protein from Aspergillus fischeri)
- Mitochondrial calcium uniporter (Cellular component from Aspergillus fischeri)
- Calcium ion (40 Da, Ligand)
Cryo-EM structure of the mitochondrial calcium uniporter from N. fischeri bound to saposin
Resolution: 5.0 Å
EM Method: Single-particle
Fitted PDBs: 6d80
Q-score: 0.235
Nguyen NX, Armache J-P, Lee C, Yang Y, Zeng W, Mootha VK, Cheng Y, Bai XC, Jiang Y
Nature (2018) 559 pp. 570-574 [ Pubmed: 29995855 DOI: doi:10.1038/s41586-018-0333-6 ]
- Calcium ion (40 Da, Ligand)
- Saposin a (6 kDa, Protein from Homo sapiens)
- Mitochondrial calcium uniporter / saposin complex (Cellular component)
- Mitochondrial calcium uniporter (Cellular component from Aspergillus fischeri)
- Saposin (Complex from Homo sapiens)
- Mitochondrial calcium uniporter (47 kDa, Protein from Aspergillus fischeri)