Cryo-EM structure of STING oligomer bound to cGAMP and NVS-STG2
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 8flk
Q-score: 0.438
Li J, Canham SM, Wu H, Henault M, Chen L, Liu G, Chen Y, Yu G, Miller HR, Hornak V, Brittain SM, Michaud GA, Tutter A, Broom W, Digan ME, McWhirter SM, Sivick KE, Pham HT, Chen CH, Tria GS, McKenna JM, Schirle M, Mao X, Nicholson TB, Wang Y, Jenkins JL, Jain RK, Tallarico JA, Patel SJ, Zheng L, Ross NT, Cho CY, Zhang X, Bai XC, Feng Y
Nat Chem Biol (2024) 20 pp. 365-372 [ Pubmed: 37828400 DOI: doi:10.1038/s41589-023-01434-y ]
- 4-({[4-(2-tert-butyl-5,5-dimethyl-1,3-dioxan-2-yl)phenyl]methyl}amino)-3-methoxybenzoic acid (427 Da, Ligand)
- Cgamp (674 Da, Ligand)
- Stimulator of interferon genes protein (39 kDa, Protein from Homo sapiens)
- Sting tetramer (300 kDa, Complex from Homo sapiens)
Cryo-EM structure of STING oligomer bound to cGAMP, NVS-STG2 and C53
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8flm
Q-score: 0.573
Li J, Canham SM, Wu H, Henault M, Chen L, Liu G, Chen Y, Yu G, Miller HR, Hornak V, Brittain SM, Michaud GA, Tutter A, Broom W, Digan ME, McWhirter SM, Sivick KE, Pham HT, Chen CH, Tria GS, McKenna JM, Schirle M, Mao X, Nicholson TB, Wang Y, Jenkins JL, Jain RK, Tallarico JA, Patel SJ, Zheng L, Ross NT, Cho CY, Zhang X, Bai XC, Feng Y
Nat Chem Biol (2024) 20 pp. 365-372 [ Pubmed: 37828400 DOI: doi:10.1038/s41589-023-01434-y ]
- 4-({[4-(2-tert-butyl-5,5-dimethyl-1,3-dioxan-2-yl)phenyl]methyl}amino)-3-methoxybenzoic acid (427 Da, Ligand)
- Stimulator of interferon genes protein (39 kDa, Protein from Homo sapiens)
- Sting tetramer (300 kDa, Complex from Homo sapiens)
- Cgamp (674 Da, Ligand)
- 1-[(2-chloro-6-fluorophenyl)methyl]-3,3-dimethyl-2-oxo-n-[(2,4,6-trifluorophenyl)methyl]-2,3-dihydro-1h-indole-6-carboxamide (490 Da, Ligand)
Cryo-EM map of octopus sensory receptor CRT1
Resolution: 2.62 Å
EM Method: Single-particle
Fitted PDBs: 8eis
Q-score: 0.574
Kang G, Allard CAH, Valencia-Montoya WA, van Giesen L, Kim JJ, Kilian PB, Bai X, Bellono NW, Hibbs RE
Nature (2023) 616 pp. 378-383 [ Pubmed: 37045917 DOI: doi:10.1038/s41586-023-05808-z ]
- 2-[2-[(1~{s},2~{s},4~{s},5'~{r},6~{r},7~{s},8~{r},9~{s},12~{s},13~{r},16~{s})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxyethyl]propane-1,3-diol (516 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Octopus sensory receptor crt1 in complex with diosgenin (200 MDa, Complex from Octopus bimaculoides)
- Octopus sensory receptor (43 kDa, Protein from Octopus bimaculoides)
Cryo-EM map of squid sensory receptor CRB1
Resolution: 3.13 Å
EM Method: Single-particle
Fitted PDBs: 8eiz
Q-score: 0.505
Kang G, Allard CAH, Valencia-Montoya WA, van Giesen L, Kim JJ, Kilian PB, Bai X, Bellono NW, Hibbs RE
Nature (2023) 616 pp. 378-383 [ Pubmed: 37045917 DOI: doi:10.1038/s41586-023-05808-z ]
- Squid sensory receptor crb1 in complex with denatonium (200 MDa, Complex from Sepioloidea lineolata)
- N-benzyl-2-(2,6-dimethylanilino)-n,n-diethyl-2-oxoethan-1-aminium (325 Da, Ligand)
- Squid sensory receptor crb1 (45 kDa, Protein from Sepioloidea lineolata)
- Water (18 Da, Ligand)
Cryo-EM structure of STRIPAK complex
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7k36
Q-score: 0.43
Jeong BC, Bae SJ, Ni L, Zhang X, Bai XC, Luo X
Nat Struct Mol Biol (2021) 28 pp. 290-299 [ DOI: doi:10.1038/s41594-021-00564-y Pubmed: 33633399 ]
- Zinc ion (65 Da, Ligand)
- Striatin-3 (77 kDa, Protein from Homo sapiens)
- Serine/threonine-protein phosphatase 2a catalytic subunit alpha isoform (35 kDa, Protein from Homo sapiens)
- Sk7 complex (817 kDa, Complex from Homo sapiens)
- Striatin-interacting protein 1 (95 kDa, Protein from Homo sapiens)
- Mob-like protein phocein (26 kDa, Protein from Homo sapiens)
- Serine/threonine-protein phosphatase 2a 65 kda regulatory subunit a alpha isoform (65 kDa, Protein from Homo sapiens)
- Manganese (ii) ion (54 Da, Ligand)
- Inositol hexakisphosphate (660 Da, Ligand)