Structure of Calcium-Sensing Receptor in complex with positive allosteric modulator '6218
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 9c1p
Q-score: 0.568
Liu F, Wu CG, Tu CL, Glenn I, Meyerowitz J, Kaplan AL, Lyu J, Cheng Z, Tarkhanova OO, Moroz YS, Irwin JJ, Chang W, Shoichet BK, Skiniotis G
Science (2024) 385 pp. eado1868-eado1868 [ Pubmed: 39298584 DOI: doi:10.1126/science.ado1868 ]
- Phosphate ion (94 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Tryptophan (204 Da, Ligand)
- (5r)-n-[2-(1,2-benzothiazol-3-yl)ethyl]-1-methyl-2,3,4,5-tetrahydro-1h-1-benzazepin-5-amine (337 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Calcium-sensing receptor bound to compound '6218 (Complex from Homo sapiens)
- Extracellular calcium-sensing receptor (105 kDa, Protein from Homo sapiens)
- Extracellular calcium-sensing receptor (108 kDa, Protein from Homo sapiens)
Structure of Calcium-Sensing Receptor in complex with positive allosteric modulator '54149
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 9c2f
Q-score: 0.553
Liu F, Wu CG, Tu CL, Glenn I, Meyerowitz J, Kaplan AL, Lyu J, Cheng Z, Tarkhanova OO, Moroz YS, Irwin JJ, Chang W, Shoichet BK, Skiniotis G
Science (2024) 385 pp. eado1868-eado1868 [ Pubmed: 39298584 DOI: doi:10.1126/science.ado1868 ]
- Phosphate ion (94 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Tryptophan (204 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- (1r)-1-(2h-1,3-benzodioxol-4-yl)-n-[2-(1,2-benzothiazol-3-yl)ethyl]ethan-1-amine (326 Da, Ligand)
- Extracellular calcium-sensing receptor (105 kDa, Protein from Homo sapiens)
- Calcium-sensing receptor bound to compound '54149 (Complex from Homo sapiens)
- Extracellular calcium-sensing receptor (108 kDa, Protein from Homo sapiens)
Liu F, Wu CG, Tu CL, Glenn I, Meyerowitz J, Kaplan AL, Lyu J, Cheng Z, Tarkhanova OO, Moroz YS, Irwin JJ, Chang W, Shoichet BK, Skiniotis G
Science (2024) 385 pp. eado1868-eado1868 [ Pubmed: 39298584 DOI: doi:10.1126/science.ado1868 ]
Focused refinement of the Heptahelical transmembrane (7TM) domain of the calcium-sensing receptor
Liu F, Wu CG, Tu CL, Glenn I, Meyerowitz J, Kaplan AL, Lyu J, Cheng Z, Tarkhanova OO, Moroz YS, Irwin JJ, Chang W, Shoichet BK, Skiniotis G
Science (2024) 385 pp. eado1868-eado1868 [ Pubmed: 39298584 DOI: doi:10.1126/science.ado1868 ]
Liu F, Wu CG, Tu CL, Glenn I, Meyerowitz J, Kaplan AL, Lyu J, Cheng Z, Tarkhanova OO, Moroz YS, Irwin JJ, Chang W, Shoichet BK, Skiniotis G
Science (2024) 385 pp. eado1868-eado1868 [ Pubmed: 39298584 DOI: doi:10.1126/science.ado1868 ]
Liu F, Wu CG, Tu CL, Glenn I, Meyerowitz J, Kaplan AL, Lyu J, Cheng Z, Tarkhanova OO, Moroz YS, Irwin JJ, Chang W, Shoichet BK, Skiniotis G
Science (2024) 385 pp. eado1868-eado1868 [ Pubmed: 39298584 DOI: doi:10.1126/science.ado1868 ]
Liu F, Wu CG, Tu CL, Glenn I, Meyerowitz J, Kaplan AL, Lyu J, Cheng Z, Tarkhanova OO, Moroz YS, Irwin JJ, Chang W, Shoichet BK, Skiniotis G
Science (2024) 385 pp. eado1868-eado1868 [ Pubmed: 39298584 DOI: doi:10.1126/science.ado1868 ]
Liu F, Wu CG, Tu CL, Glenn I, Meyerowitz J, Kaplan AL, Lyu J, Cheng Z, Tarkhanova OO, Moroz YS, Irwin JJ, Chang W, Shoichet BK, Skiniotis G
Science (2024) 385 pp. eado1868-eado1868 [ Pubmed: 39298584 DOI: doi:10.1126/science.ado1868 ]
Papasergi-Scott MM, Pérez-Hernández G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi C, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G
Nature (2024) [ Pubmed: 38480881 DOI: 10.1038/s41586-024-07153-1 ]
Image sets:
- Unaligned multi-frame micrographs of β2-adrenergic receptor in complex with GTP-bound G protein Gs, vitrified 10 seconds after GTP addition (Collection 1, Grid B)
- Unaligned multi-frame micrographs of β2-adrenergic receptor in complex with GTP-bound G protein Gs, vitrified 10 seconds after GTP addition (Collection 3, Grid C)
- Unaligned multi-frame micrographs of β2-adrenergic receptor in complex with GTP-bound G protein Gs, vitrified 10 seconds after GTP addition (Collection 2, Grid B)
- Unaligned multi-frame micrographs of β2-adrenergic receptor in complex with GTP-bound G protein Gs, vitrified 10 seconds after GTP addition (Collection 1, Grid A)
Papasergi-Scott MM, Pérez-Hernández G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G
Nature (2024) [ Pubmed: 38480881 DOI: 10.1038/s41586-024-07153-1 ]
Image sets: