CryoEM Structure of Inactive NTSR1 Bound to SR48692 and Nb6
Resolution: 2.4 Å
EM Method: Single-particle
Fitted PDBs: 7ul2
Q-score: 0.645
Robertson MJ, Papasergi-Scott MM, He F, Seven AB, Meyerowitz JG, Panova O, Peroto MC, Che T, Skiniotis G
Nat Struct Mol Biol (2022) 29 pp. 1188-1195 [ DOI: doi:10.1038/s41594-022-00859-8 Pubmed: 36396979 ]
- Ntsr1 (Complex from Homo sapiens)
- Neurotensin receptor 1 (47 kDa, Protein from Homo sapiens)
- Complex of ntsr1 and nb6 (Complex from Homo sapiens)
- Nanobody 6 (14 kDa, Protein from Lama glama)
- Sodium ion (22 Da, Ligand)
- Nb6 (Complex from Lama glama)
- 2-[[1-(7-chloranylquinolin-4-yl)-5-(2,6-dimethoxyphenyl)pyrazol-3-yl]carbonylamino]adamantane-2-carboxylic acid (587 Da, Ligand)
- Water (18 Da, Ligand)
CryoEM Structure of Inactive H2R Bound to Famotidine, Nb6M, and NabFab
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7ul3
Q-score: 0.36
Robertson MJ, Papasergi-Scott MM, He F, Seven AB, Meyerowitz JG, Panova O, Peroto MC, Che T, Skiniotis G
Nat Struct Mol Biol (2022) 29 pp. 1188-1195 [ DOI: doi:10.1038/s41594-022-00859-8 Pubmed: 36396979 ]
- Nanobody 6m (14 kDa, Protein from synthetic construct)
- H2r (Complex from Homo sapiens)
- Nabfab hc (25 kDa, Protein from synthetic construct)
- Famotidine (339 Da, Ligand)
- Nb6m (Complex from Lama glama)
- Nabfab lc (23 kDa, Protein from synthetic construct)
- Nabfab (Complex from synthetic construct)
- Histamine h2 receptor (44 kDa, Protein from Homo sapiens)
- Complex of h2r, nb6m, and nabfab (Complex from Homo sapiens)
CryoEM Structure of Inactive MOR Bound to Alvimopan and Mb6
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 7ul4
Q-score: 0.563
Robertson MJ, Papasergi-Scott MM, He F, Seven AB, Meyerowitz JG, Panova O, Peroto MC, Che T, Skiniotis G
Nat Struct Mol Biol (2022) 29 pp. 1188-1195 [ DOI: doi:10.1038/s41594-022-00859-8 Pubmed: 36396979 ]
- Complex of mor and nb6 (Complex from Mus musculus)
- Megabody 6 (55 kDa, Protein from synthetic construct)
- N-[(2s)-2-{[(3r,4r)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]methyl}-3-phenylpropanoyl]glycine (424 Da, Ligand)
- Mb6 (Complex from Lama glama)
- Mor (Complex from Mus musculus)
- Mu-type opioid receptor (47 kDa, Protein from Mus musculus)
- Water (18 Da, Ligand)
CryoEM Structure of Inactive SSTR2 bound to Nb6
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7ul5
Q-score: 0.562
Robertson MJ, Papasergi-Scott MM, He F, Seven AB, Meyerowitz JG, Panova O, Peroto MC, Che T, Skiniotis G
Nat Struct Mol Biol (2022) 29 pp. 1188-1195 [ DOI: doi:10.1038/s41594-022-00859-8 Pubmed: 36396979 ]
- Somatostatin receptor type 2 (46 kDa, Protein from Homo sapiens)
- Complex of sstr2 and nb6 (Complex from Homo sapiens)
- Nanobody 6 (14 kDa, Protein from Lama glama)
- Nb6 (Complex from Lama glama)
- Sstr2 (Complex from Homo sapiens)