Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8xyd
Q-score: 0.366
Fan W, Xu Y, He X, Luo P, Zhu J, Li J, Wang R, Yuan Q, Wu K, Hu W, Zhao Y, Xu S, Cheng X, Wang Y, Xu HE, Zhuang Y
Cell Rep (2024) 43 pp. 114422-114422 [ DOI: doi:10.1016/j.celrep.2024.114422 Pubmed: 38943642 ]
- Ptafr-paf g protein complex (Complex from Homo sapiens)
- Scfv16 (26 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Platelet-activating factor receptor (39 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- (2r)-2-(acetyloxy)-3-(hexadecyloxy)propyl 2-(trimethylammonio)ethyl phosphate (523 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
Cryo-EM structure of prolactin-releasing peptide recognition with Gi
Resolution: 2.97 Å
EM Method: Single-particle
Fitted PDBs: 8zps
Q-score: 0.406
Li Y, Yuan Q, He X, Zhang Y, You C, Wu C, Li J, Xu HE, Zhao LH
Cell Discov (2024) 10 pp. 91-91 [ DOI: doi:10.1038/s41421-024-00724-6 Pubmed: 39223120 ]
- Prolactin-releasing peptide receptor (41 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha-1 (41 kDa, Protein from Homo sapiens)
- Molecular mechanism of prolactin-releasing peptide recognition with gi (160 kDa, Complex from Homo sapiens)
- Scfv16 (26 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Prolactin-releasing peptide prrp20 (2 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
Cryo-EM structure of prolactin-releasing peptide recognition with Gq
Resolution: 2.96 Å
EM Method: Single-particle
Fitted PDBs: 8zpt
Q-score: 0.432
Li Y, Yuan Q, He X, Zhang Y, You C, Wu C, Li J, Xu HE, Zhao LH
Cell Discov (2024) 10 pp. 91-91 [ DOI: doi:10.1038/s41421-024-00724-6 Pubmed: 39223120 ]
- Scfv16 (26 kDa, Protein from Homo sapiens)
- Prolactin-releasing peptide receptor (41 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(324) subunit alpha-1, (41 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Molecular mechanism of prolactin-releasing peptide recognition with gq (160 kDa, Complex from Homo sapiens)
- Prolactin-releasing peptide prrp20 (2 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
Cryo-EM structure of Melanin-Concentrating Hormone Receptor 1 with MCH
Resolution: 3.01 Å
EM Method: Single-particle
Fitted PDBs: 8wss
Q-score: 0.495
He Q, Yuan Q, Shan H, Wu C, Gu Y, Wu K, Hu W, Zhang Y, He X, Xu HE, Zhao LH
Cell Discov (2024) 10 pp. 48-48 [ Pubmed: 38710677 DOI: doi:10.1038/s41421-024-00679-8 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Pro-mch (2 kDa, Protein from Homo sapiens)
- Scfv16 (30 kDa, Protein from Mus musculus)
- Melanin-concentrating hormone receptor 1 (43 kDa, Protein from Homo sapiens)
- Mechanisms of ligand recognition and activation of melanin-concentrating hormone receptors1 (160 kDa, Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (41 kDa, Protein from Homo sapiens)
Cryo-EM structure of Melanin-Concentrating Hormone Receptor 2 with MCH
Resolution: 2.4 Å
EM Method: Single-particle
Fitted PDBs: 8wst
Q-score: 0.531
He Q, Yuan Q, Shan H, Wu C, Gu Y, Wu K, Hu W, Zhang Y, He X, Xu HE, Zhao LH
Cell Discov (2024) 10 pp. 48-48 [ Pubmed: 38710677 DOI: doi:10.1038/s41421-024-00679-8 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Pro-mch (2 kDa, Protein from Homo sapiens)
- Melanin-concentrating hormone receptors2 complex with mch (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(q) subunit alpha-1 (28 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Melanin-concentrating hormone receptor 2 (37 kDa, Protein from Homo sapiens)
- Nb35 (14 kDa, Protein from Homo sapiens)
Structure of 26RFa-pyroglutamylated RFamide peptide receptor complex
Resolution: 2.73 Å
EM Method: Single-particle
Fitted PDBs: 8wz2
Q-score: 0.45
Jin S, Guo S, Xu Y, Li X, Wu C, He X, Pan B, Xin W, Zhang H, Hu W, Yin Y, Zhang T, Wu K, Yuan Q, Xu HE, Xie X, Jiang Y
Cell Discov (2024) 10 pp. 58-58 [ Pubmed: 38830850 DOI: doi:10.1038/s41421-024-00670-3 ]
- Structure of 26rfa-pyroglutamylated rfamide peptide receptor-g protein complex (160 kDa, Complex from Homo sapiens)
- Scfv16 (26 kDa, Protein from Homo sapiens)
- Orexigenic neuropeptide qrfp (2 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Pyroglutamylated rf-amide peptide receptor (49 kDa, Protein from Homo sapiens)
- G-alpha q (41 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
Cryo-EM structure of ACTH-bound melanocortin-2 receptor in complex with MRAP1 and Gs protein
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8gy7
Q-score: 0.453
Luo P, Feng W, Ma S, Dai A, Wu K, Chen X, Yuan Q, Cai X, Yang D, Wang MW, Eric Xu H, Jiang Y
Cell Res (2023) 33 pp. 46-54 [ DOI: doi:10.1038/s41422-022-00751-6 Pubmed: 36588120 ]
- Mrap1 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Acth (Complex from Homo sapiens)
- Corticotropin (2 kDa, Protein from synthetic construct)
- Acth-bound melanocortin-2 receptor in complex with mrap1 and gs protein (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (Complex from Homo sapiens)
- Melanocortin-2 receptor accessory protein (20 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-3,guanine nucleotide-binding protein g(s) subunit alpha isoforms xlas (41 kDa, Protein from Homo sapiens)
- Soluble cytochrome b562,adrenocorticotropic hormone receptor,melanocortin-2 receptor,adrenocorticotropic hormone receptor,adrenocorticotropic hormone receptor (67 kDa, Protein from Homo sapiens)
- Melanocortin-2 receptor (Complex from Homo sapiens)
SARS-CoV-2 Omicron BA.1 Variant Spike Trimer with two mouse ACE2 Bound
Resolution: 3.24 Å
EM Method: Single-particle
Fitted PDBs: 7xo4
Q-score: 0.212
Xu Y, Wu C, Cao X, Gu C, Liu H, Jiang M, Wang X, Yuan Q, Wu K, Liu J, Wang D, He X, Wang X, Deng SJ, Xu HE, Yin W
Cell Res (2022) 32 pp. 609-620 [ DOI: doi:10.1038/s41422-022-00672-4 Pubmed: 35641567 ]
- Mouse ace2 (Complex)
- Spike glycoprotein (133 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Angiotensin-converting enzyme 2 (92 kDa, Protein from Mus musculus)
- Sars-cov-2 omicron ba.1 variant spike trimer with two mouse ace2 bound (Complex from Severe acute respiratory syndrome coronavirus 2)
- Zinc ion (65 Da, Ligand)
- Sars-cov-2 omicron ba.1 variant spike trimer (Complex from Mus musculus)
SARS-CoV-2 Omicron BA.1 Variant Spike Trimer with one mouse ACE2 Bound
Resolution: 3.13 Å
EM Method: Single-particle
Fitted PDBs: 7xo5
Q-score: 0.315
Xu Y, Wu C, Cao X, Gu C, Liu H, Jiang M, Wang X, Yuan Q, Wu K, Liu J, Wang D, He X, Wang X, Deng SJ, Xu HE, Yin W
Cell Res (2022) 32 pp. 609-620 [ DOI: doi:10.1038/s41422-022-00672-4 Pubmed: 35641567 ]
- Mouse ace2 (Complex)
- Spike glycoprotein (133 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Angiotensin-converting enzyme 2 (92 kDa, Protein from Mus musculus)
- Sars-cov-2 omicron ba.1 variant spike trimer with one mouse ace2 bound (Complex from Severe acute respiratory syndrome coronavirus 2)
- Zinc ion (65 Da, Ligand)
- Sars-cov-2 omicron ba.1 variant spike trimer (Complex from Mus musculus)
SARS-CoV-2 Omicron BA.1 Variant RBD with mouse ACE2 Bound
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 7xo6
Q-score: 0.472
Xu Y, Wu C, Cao X, Gu C, Liu H, Jiang M, Wang X, Yuan Q, Wu K, Liu J, Wang D, He X, Wang X, Deng SJ, Xu HE, Yin W
Cell Res (2022) 32 pp. 609-620 [ DOI: doi:10.1038/s41422-022-00672-4 Pubmed: 35641567 ]
- Spike glycoprotein (133 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Mouse ace2 (Complex from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 omicron ba.1 variant rbd with mouse ace2 bound (Complex from Mus musculus)
- Angiotensin-converting enzyme 2 (92 kDa, Protein from Mus musculus)
- Zinc ion (65 Da, Ligand)
- Sars-cov-2 omicron ba.1 variant rbd (Complex)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)