Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8xyd
Q-score: 0.366
Fan W, Xu Y, He X, Luo P, Zhu J, Li J, Wang R, Yuan Q, Wu K, Hu W, Zhao Y, Xu S, Cheng X, Wang Y, Xu HE, Zhuang Y
Cell Rep (2024) 43 pp. 114422-114422 [ DOI: doi:10.1016/j.celrep.2024.114422 Pubmed: 38943642 ]
- Ptafr-paf g protein complex (Complex from Homo sapiens)
- Scfv16 (26 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Platelet-activating factor receptor (39 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- (2r)-2-(acetyloxy)-3-(hexadecyloxy)propyl 2-(trimethylammonio)ethyl phosphate (523 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
LPI-bound GPR55 in complex with G13
Resolution: 2.85 Å
EM Method: Single-particle
Fitted PDBs: 8zx4
Q-score: 0.531
Xia R, Yuan Q, Wang N, Hou L, Abe J, Song J, Ito Y, Xu HE, He Y
Cell Res (2025) 35 pp. 76-79 [ DOI: doi:10.1038/s41422-024-01044-w Pubmed: 39482404 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- G-protein coupled receptor 55 (34 kDa, Protein from Homo sapiens)
- Engineered minigalpha 13 (26 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Gpcr/g-protein complex (Complex from Homo sapiens)
- [(2~{r})-2-oxidanyl-3-[oxidanyl-[(2~{s},3~{r},5~{r},6~{r})-2,3,4,5,6-pentakis(oxidanyl)cyclohexyl]oxy-phosphoryl]oxy-propyl] hexadecanoate (572 Da, Ligand)
AM251-bound GPR55 in complex with G13
Resolution: 3.03 Å
EM Method: Single-particle
Fitted PDBs: 8zx5
Q-score: 0.426
Xia R, Yuan Q, Wang N, Hou L, Abe J, Song J, Ito Y, Xu HE, He Y
Cell Res (2025) 35 pp. 76-79 [ DOI: doi:10.1038/s41422-024-01044-w Pubmed: 39482404 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Engineered minigalpha 13 (26 kDa, Protein from Homo sapiens)
- 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-~{n}-piperidin-1-yl-pyrazole-3-carboxamide (555 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Gpcr/g-protein complex (Complex from Homo sapiens)
- G-protein coupled receptor 55 (36 kDa, Protein from Homo sapiens)
Cryo-EM structure of prolactin-releasing peptide recognition with Gi
Resolution: 2.97 Å
EM Method: Single-particle
Fitted PDBs: 8zps
Q-score: 0.406
Li Y, Yuan Q, He X, Zhang Y, You C, Wu C, Li J, Xu HE, Zhao LH
Cell Discov (2024) 10 pp. 91-91 [ DOI: doi:10.1038/s41421-024-00724-6 Pubmed: 39223120 ]
- Prolactin-releasing peptide receptor (41 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha-1 (41 kDa, Protein from Homo sapiens)
- Molecular mechanism of prolactin-releasing peptide recognition with gi (160 kDa, Complex from Homo sapiens)
- Scfv16 (26 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Prolactin-releasing peptide prrp20 (2 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
Cryo-EM structure of prolactin-releasing peptide recognition with Gq
Resolution: 2.96 Å
EM Method: Single-particle
Fitted PDBs: 8zpt
Q-score: 0.432
Li Y, Yuan Q, He X, Zhang Y, You C, Wu C, Li J, Xu HE, Zhao LH
Cell Discov (2024) 10 pp. 91-91 [ DOI: doi:10.1038/s41421-024-00724-6 Pubmed: 39223120 ]
- Scfv16 (26 kDa, Protein from Homo sapiens)
- Prolactin-releasing peptide receptor (41 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(324) subunit alpha-1, (41 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Molecular mechanism of prolactin-releasing peptide recognition with gq (160 kDa, Complex from Homo sapiens)
- Prolactin-releasing peptide prrp20 (2 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
Cryo-EM structure of the retatrutide-bound human GLP-1R-Gs complex
Resolution: 2.68 Å
EM Method: Single-particle
Fitted PDBs: 8yw3
Q-score: 0.514
Li W, Zhou Q, Cong Z, Yuan Q, Li W, Zhao F, Xu HE, Zhao LH, Yang D, Wang MW
Cell Discov (2024) 10 pp. 77-77 [ Pubmed: 39019866 DOI: doi:10.1038/s41421-024-00700-0 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Retatrutide (3 kDa, Protein from Homo sapiens)
- Glucagon-like peptide 1 receptor (50 kDa, Protein from Homo sapiens)
- Nanobody-35 (15 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Cryo-em structure of the human glucagon-like peptide-1 receptor in complex with retatrutide and g protein (Complex from Homo sapiens)
Cryo-EM structure of the retatrutide-bound human GIPR-Gs complex
Resolution: 3.26 Å
EM Method: Single-particle
Fitted PDBs: 8yw4
Q-score: 0.379
Li W, Zhou Q, Cong Z, Yuan Q, Li W, Zhao F, Xu HE, Zhao LH, Yang D, Wang MW
Cell Discov (2024) 10 pp. 77-77 [ Pubmed: 39019866 DOI: doi:10.1038/s41421-024-00700-0 ]
- Mini-gs (41 kDa, Protein from Homo sapiens)
- Gastric inhibitory polypeptide receptor (65 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Cryo-em structure of the retatrutide-bound human gipr-gs complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Nanobody-35 (15 kDa, Protein from synthetic construct)
- Retatrutide (3 kDa, Protein from Homo sapiens)
Cryo-EM structure of the retatrutide-bound human GCGR-Gs complex
Resolution: 2.84 Å
EM Method: Single-particle
Fitted PDBs: 8yw5
Q-score: 0.57
Li W, Zhou Q, Cong Z, Yuan Q, Li W, Zhao F, Xu HE, Zhao LH, Yang D, Wang MW
Cell Discov (2024) 10 pp. 77-77 [ Pubmed: 39019866 DOI: doi:10.1038/s41421-024-00700-0 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Glucagon receptor (46 kDa, Protein from Homo sapiens)
- Cryo-em structure of the retatrutide-bound human gcgr-gs complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Retatrutide (3 kDa, Protein from Homo sapiens)
- Nanobody-35 (15 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
A Cryo-EM structure of Bitter taste receptor TAS2R14 with Ggust
Resolution: 2.89 Å
EM Method: Single-particle
Fitted PDBs: 9iix
Q-score: 0.4
Tao L, Wang D, Yuan Q, Zhao F, Zhang Y, Du T, Shen S, Xu HE, Li Y, Yang D, Duan J
Cell Res (2024) 34 pp. 735-738 [ Pubmed: 38969802 DOI: doi:10.1038/s41422-024-00995-4 ]
- Tas2r14 with ggust complex (Complex from Homo sapiens)
- 4-methyl-n-[(2m)-2-(1h-tetrazol-5-yl)phenyl]-6-(trifluoromethyl)pyrimidin-2-amine (321 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein mini g(s) subunit alpha-1 (28 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Taste receptor type 2 member 14 (36 kDa, Protein from Homo sapiens)