Cryo-EM structure of SNAP-94847-bound MCHR1, S1 state
Resolution: 3.33 Å
EM Method: Single-particle
Fitted PDBs: 8yns
Q-score: 0.476
Ye X, Liu G, Li X, He B, Tao Y, Guan J, Mu Y, Liu H, Gong W
Cell Discov (2024) 10 pp. 124-124 [ DOI: doi:10.1038/s41421-024-00754-0 Pubmed: 39616153 ]
- Antibody 1b3 fab light chain (23 kDa, Protein from synthetic construct)
- Snap-94847-mchr1-fab1b3-glue complex (Complex from Homo sapiens)
- Melanin-concentrating hormone receptor 1,soluble cytochrome b562 (64 kDa, Protein from Homo sapiens)
- Glue molecule 4-9 (30 kDa, Protein from synthetic construct)
- Antibody 1b3 fab heavy chain (25 kDa, Protein from synthetic construct)
- ~{n}-[3-[1-[[4-[3,4-bis(fluoranyl)phenoxy]phenyl]methyl]piperidin-4-yl]-4-methyl-phenyl]-2-methyl-propanamide (478 Da, Ligand)
Cryo-EM structure of SNAP-94847-bound MCHR1, S2 state
Resolution: 3.43 Å
EM Method: Single-particle
Fitted PDBs: 8ynt
Q-score: 0.422
Ye X, Liu G, Li X, He B, Tao Y, Guan J, Mu Y, Liu H, Gong W
Cell Discov (2024) 10 pp. 124-124 [ DOI: doi:10.1038/s41421-024-00754-0 Pubmed: 39616153 ]
- Antibody 1b3 fab light chain (23 kDa, Protein from synthetic construct)
- Snap-94847-mchr1-fab1b3-glue complex (Complex from Homo sapiens)
- Melanin-concentrating hormone receptor 1,soluble cytochrome b562 (64 kDa, Protein from Homo sapiens)
- Glue molecule 4-9 (30 kDa, Protein from synthetic construct)
- Antibody 1b3 fab heavy chain (25 kDa, Protein from synthetic construct)
- ~{n}-[3-[1-[[4-[3,4-bis(fluoranyl)phenoxy]phenyl]methyl]piperidin-4-yl]-4-methyl-phenyl]-2-methyl-propanamide (478 Da, Ligand)
MCH-MCHR1-Gi complex, T1 state
Resolution: 2.61 Å
EM Method: Single-particle
Fitted PDBs: 8wwk
Q-score: 0.611
Ye X, Liu G, Li X, He B, Tao Y, Guan J, Mu Y, Liu H, Gong W
Cell Discov (2024) 10 pp. 124-124 [ DOI: doi:10.1038/s41421-024-00754-0 Pubmed: 39616153 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Mch-mchr1-gi complex t1 state (Complex from Homo sapiens)
- Melanin-concentrating hormone (2 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Fusion protein 1,melanin-concentrating hormone receptor 1,fusion protein 2 (68 kDa, Protein from Homo sapiens)
- Antibody fragment scfv16 (27 kDa, Protein from synthetic construct)
MCH-MCHR1-Gi complex, T2 state
Resolution: 2.78 Å
EM Method: Single-particle
Fitted PDBs: 8wwl
Q-score: 0.573
Ye X, Liu G, Li X, He B, Tao Y, Guan J, Mu Y, Liu H, Gong W
Cell Discov (2024) 10 pp. 124-124 [ DOI: doi:10.1038/s41421-024-00754-0 Pubmed: 39616153 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Melanin-concentrating hormone (2 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Fusion protein 1,melanin-concentrating hormone receptor 1,fusion protein 2 (68 kDa, Protein from Homo sapiens)
- Mch-mchr1-gi complex t2 state (Complex from Homo sapiens)
- Antibody fragment scfv16 (27 kDa, Protein from synthetic construct)
MCH-MCHR1-Gi complex, L2 state
Resolution: 2.81 Å
EM Method: Single-particle
Fitted PDBs: 8wwm
Q-score: 0.531
Ye X, Liu G, Li X, He B, Tao Y, Guan J, Mu Y, Liu H, Gong W
Cell Discov (2024) 10 pp. 124-124 [ DOI: doi:10.1038/s41421-024-00754-0 Pubmed: 39616153 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Mch-mchr1-gi complex l2 state (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Melanin-concentrating hormone (2 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Fusion protein 1,melanin-concentrating hormone receptor 1,fusion protein 2 (68 kDa, Protein from Homo sapiens)
- Antibody fragment scfv16 (27 kDa, Protein from synthetic construct)
Resolution: 2.65 Å
EM Method: Single-particle
Fitted PDBs: 8wwn
Q-score: 0.6
Ye X, Liu G, Li X, He B, Tao Y, Guan J, Mu Y, Liu H, Gong W
Cell Discov (2024) 10 pp. 124-124 [ DOI: doi:10.1038/s41421-024-00754-0 Pubmed: 39616153 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Mch-mchr1-gi complex l1 state (Complex from Homo sapiens)
- Melanin-concentrating hormone (2 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Fusion protein 1,melanin-concentrating hormone receptor 1,fusion protein 2 (68 kDa, Protein from Homo sapiens)
- Antibody fragment scfv16 (27 kDa, Protein from synthetic construct)
Cryo-EM structure of kisspeptin receptor bound to KP-10
Resolution: 3.06 Å
EM Method: Single-particle
Fitted PDBs: 8zjd
Q-score: 0.495
Shen S, Wang D, Liu H, He X, Cao Y, Chen J, Li S, Cheng X, Xu HE, Duan J
Cell Rep (2024) 43 pp. 114389-114389 [ DOI: doi:10.1016/j.celrep.2024.114389 Pubmed: 38935498 ]
- Kiss-1 receptor,kiss-1 receptor,kiss-1 receptor,kiss-1 receptor,kiss-1 receptor, g-protein coupled receptor 54, gpr54, kiss1r (55 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1,guanine nucleotide-binding protein g(q) subunit alpha (41 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Mus sp.)
- Cryo-em structure of kisspeptin receptor in complex with g proteins (Complex from Homo Sapiens)
- Kisspeptin-10 (1 kDa, Protein from synthetic construct)
Cryo-EM structure of kisspeptin receptor bound to TAK-448
Resolution: 3.07 Å
EM Method: Single-particle
Fitted PDBs: 8zje
Q-score: 0.504
Shen S, Wang D, Liu H, He X, Cao Y, Chen J, Li S, Cheng X, Xu HE, Duan J
Cell Rep (2024) 43 pp. 114389-114389 [ DOI: doi:10.1016/j.celrep.2024.114389 Pubmed: 38935498 ]
- Ace-dty-hyp-asn-thr-phe-xza-leu-nmm-trp-nh2 (1 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i) subunit alpha-1,guanine nucleotide-binding protein g(q) subunit alpha (41 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Kiss-1 receptor (42 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Mus sp.)
- Cryo-em structure of kisspeptin receptor in complex with g proteins (Complex from Homo Sapiens)
Cryo-EM structure of succinate receptor SUCR1 bound to compound 31
Resolution: 2.48 Å
EM Method: Single-particle
Fitted PDBs: 8ykv
Q-score: 0.585
Li C, Liu H, Li J, He X, Zhu H, Fu W, Xu HE
Cell Res (2024) 34 pp. 594-596 [ DOI: doi:10.1038/s41422-024-00984-7 Pubmed: 38834763 ]
- (2~{s})-2-[[6-[4-(trifluoromethyloxy)phenyl]pyridin-2-yl]carbonylamino]butanedioic acid (398 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Succinate receptor 1 (38 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Antibody fragment scfv16 (26 kDa, Protein from synthetic construct)
- Cryo-em structure of succinate receptor sucr1 bound to succinic acid (160 kDa, Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
Cryo-EM structure of succinate receptor SUCR1 bound to succinic acid
Resolution: 2.75 Å
EM Method: Single-particle
Fitted PDBs: 8ykw
Q-score: 0.553
Li C, Liu H, Li J, He X, Zhu H, Fu W, Xu HE
Cell Res (2024) 34 pp. 594-596 [ DOI: doi:10.1038/s41422-024-00984-7 Pubmed: 38834763 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Succinate receptor 1 (38 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Succinic acid (118 Da, Ligand)
- Antibody fragment scfv16 (26 kDa, Protein from synthetic construct)
- Cryo-em structure of succinate receptor sucr1 bound to succinic acid (160 kDa, Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)