Kappa opioid receptor:Galphai protein in complex with inverse agonist JDTic, Original map receptor
Tyson AS, Khan S, Motiwala Z, Han GW, Zhang Z, Ranjbar M, Styrpejko D, Ramos-Gonzalez N, Woo S, Villers K, Landaker D, Kenakin T, Shenvi R, Majumdar S, Gati C
Nat Chem Biol (2025) [ Pubmed: 39775170 DOI: doi:10.1038/s41589-024-01812-0 ]
Kappa opioid receptor:Galphai protein in complex with inverse agonist JDTic, Original map G protein
Tyson AS, Khan S, Motiwala Z, Han GW, Zhang Z, Ranjbar M, Styrpejko D, Ramos-Gonzalez N, Woo S, Villers K, Landaker D, Kenakin T, Shenvi R, Majumdar S, Gati C
Nat Chem Biol (2025) [ Pubmed: 39775170 DOI: doi:10.1038/s41589-024-01812-0 ]
Kappa opioid receptor:Galphai protein in complex with inverse agonist norBNI, Original map G protein
Tyson AS, Khan S, Motiwala Z, Han GW, Zhang Z, Ranjbar M, Styrpejko D, Ramos-Gonzalez N, Woo S, Villers K, Landaker D, Kenakin T, Shenvi R, Majumdar S, Gati C
Nat Chem Biol (2025) [ Pubmed: 39775170 DOI: doi:10.1038/s41589-024-01812-0 ]
Kappa opioid receptor:Galphai protein in complex with inverse agonist GB18, Original map receptor
Tyson AS, Khan S, Motiwala Z, Han GW, Zhang Z, Ranjbar M, Styrpejko D, Ramos-Gonzalez N, Woo S, Villers K, Landaker D, Kenakin T, Shenvi R, Majumdar S, Gati C
Nat Chem Biol (2025) [ Pubmed: 39775170 DOI: doi:10.1038/s41589-024-01812-0 ]
Kappa opioid receptor:Galphai protein in complex with inverse agonist GB18, Original map G protein
Tyson AS, Khan S, Motiwala Z, Han GW, Zhang Z, Ranjbar M, Styrpejko D, Ramos-Gonzalez N, Woo S, Villers K, Landaker D, Kenakin T, Shenvi R, Majumdar S, Gati C
Nat Chem Biol (2025) [ Pubmed: 39775170 DOI: doi:10.1038/s41589-024-01812-0 ]
The cryo-EM structure of TdpAB in complex with AMPPNP and PT-DNA
An T, Tan Q, Jiang L, Liu L, Jiang X, Liu L, Chang X, Tian X, Deng Z, Gao S, Wang L, Chen S
Nat Chem Biol (2025) [ Pubmed: 39820821 DOI: doi:10.1038/s41589-024-01832-w ]
- Tdpb (42 kDa, Protein from Thermus antranikianii DSM 12462)
- Dna (5'-d(p*gp*cp*cp*cp*tp*tp*tp*tp*gp*cp*ap*a)-3') (3 kDa, DNA from Thermus antranikianii DSM 12462)
- Dna (5'-d(p*tp*tp*gp*cp*ap*ap*ap*ap*gp*gp*gp*c)-3') (3 kDa, DNA from Thermus antranikianii DSM 12462)
- Phosphoaminophosphonic acid-adenylate ester (506 Da, Ligand)
- Tdpab in complex with amppnp and pt-dna (Complex from Thermus antranikianii DSM 12462)
- Tdpa (66 kDa, Protein from Thermus antranikianii DSM 12462)
The cryo-EM structure of TdpAB complex
Resolution: 2.76 Å
EM Method: Single-particle
Fitted PDBs: 8wet
Q-score: 0.562
An T, Tan Q, Jiang L, Liu L, Jiang X, Liu L, Chang X, Tian X, Deng Z, Gao S, Wang L, Chen S
Nat Chem Biol (2025) [ Pubmed: 39820821 DOI: doi:10.1038/s41589-024-01832-w ]
- Tdpa (66 kDa, Protein from Thermus antranikianii DSM 12462)
- Tdpb (42 kDa, Protein from Thermus antranikianii DSM 12462)
- Tdpab complex (Complex from Thermus antranikianii DSM 12462)
The cryo-EM structure of TdpAB in complex with AMPPNP and DNA
Resolution: 2.67 Å
EM Method: Single-particle
Fitted PDBs: 8wfd
Q-score: 0.599
An T, Tan Q, Jiang L, Liu L, Jiang X, Liu L, Chang X, Tian X, Deng Z, Gao S, Wang L, Chen S
Nat Chem Biol (2025) [ DOI: doi:10.1038/s41589-024-01832-w Pubmed: 39820821 ]
- Tdpab in complex with amppnp and dna (Complex from Thermus antranikianii DSM 12462)
- Tdpa (66 kDa, Protein from Thermus antranikianii DSM 12462)
- Dna (5'-d(p*tp*tp*gp*cp*ap*ap*ap*ap*gp*gp*gp*c)-3') (3 kDa, DNA from Thermus antranikianii DSM 12462)
- Phosphoaminophosphonic acid-adenylate ester (506 Da, Ligand)
- Tdpb (42 kDa, Protein from Thermus antranikianii DSM 12462)
- Dna (5'-d(p*gp*cp*cp*cp*tp*tp*tp*tp*gp*cp*ap*a)-3') (3 kDa, DNA from Thermus antranikianii DSM 12462)
Kappa opioid receptor:Galphai protein in complex with inverse agonist norBNI
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8vve
Q-score: 0.333
Tyson AS, Khan S, Motiwala Z, Han GW, Zhang Z, Ranjbar M, Styrpejko D, Ramos-Gonzalez N, Woo S, Villers K, Landaker D, Kenakin T, Shenvi R, Majumdar S, Gati C
Nat Chem Biol (2025) [ Pubmed: 39775170 DOI: doi:10.1038/s41589-024-01812-0 ]
- Scfv16 (26 kDa, Protein from Mus musculus)
- (4bs,8r,8as,10as,11r,14as,19ar,20br)-7,12-bis(cyclopropylmethyl)-5,6,7,8,9,10,11,12,13,14,20,20b-dodecahydro-19ah-4,8:11,15-dimethanobis[1]benzofuro[2,3-a:3',2'-i]dipyrido[4,3-b:3',4'-h]carbazole-1,8a,10a,18-tetrol (661 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Kappa-type opioid receptor (42 kDa, Protein from Homo sapiens)
- Kappa opioid receptor in complex with heterotrimeric g protein (gai/b/g) and inverse agonist norbni (130 kDa, Complex from Homo sapiens)