The insulin receptor ectodomain in complex with a venom hybrid insulin analog - "head" region
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7mqo
Q-score: 0.44
Xiong X, Blakely A, Kim JH, Menting JG, Schafer IB, Schubert HL, Agrawal R, Gutmann T, Delaine C, Zhang YW, Artik GO, Merriman A, Eckert D, Lawrence MC, Coskun U, Fisher SJ, Forbes BE, Safavi-Hemami H, Hill CP, Chou DH
Nat Chem Biol (2022) 18 pp. 511-519 [ DOI: doi:10.1038/s41589-022-00981-0 Pubmed: 35289328 ]
- Insulin receptor ectodomain in complex with insulin analog vh-ins-hslq - focused refinement. (209 kDa, Complex from Homo sapiens)
- Insulin a chain (2 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Insulin b chain (2 kDa, Protein from Homo sapiens)
- Isoform short of insulin receptor (104 kDa, Protein from Homo sapiens)
The insulin receptor ectodomain in complex with four venom hybrid insulins - symmetric conformation
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 7mqr
Q-score: 0.304
Xiong X, Blakely A, Kim JH, Menting JG, Schafer IB, Schubert HL, Agrawal R, Gutmann T, Delaine C, Zhang YW, Artik GO, Merriman A, Eckert D, Lawrence MC, Coskun U, Fisher SJ, Forbes BE, Safavi-Hemami H, Hill CP, Chou DH
Nat Chem Biol (2022) 18 pp. 511-519 [ DOI: doi:10.1038/s41589-022-00981-0 Pubmed: 35289328 ]
- Insulin receptor ectodomain in complex with insulin analog vh-ins-hslq - whole ectodomain. (209 kDa, Complex from Homo sapiens)
- Isoform short of insulin receptor (104 kDa, Protein from Homo sapiens)
- Insulin a chain (2 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Insulin b chain (2 kDa, Protein from Homo sapiens)
Resolution: 4.4 Å
EM Method: Single-particle
Fitted PDBs: 7mqs
Q-score: 0.232
Xiong X, Blakely A, Kim JH, Menting JG, Schafer IB, Schubert HL, Agrawal R, Gutmann T, Delaine C, Zhang YW, Artik GO, Merriman A, Eckert D, Lawrence MC, Coskun U, Fisher SJ, Forbes BE, Safavi-Hemami H, Hill CP, Chou DH
Nat Chem Biol (2022) 18 pp. 511-519 [ DOI: doi:10.1038/s41589-022-00981-0 Pubmed: 35289328 ]
- Isoform short of insulin receptor (104 kDa, Protein from Homo sapiens)
- Insulin receptor ectodomain in complex with insulin analog vh-ins-hslq - asymmetric conformation. (209 kDa, Complex from Homo sapiens)
- Insulin b chain (2 kDa, Protein from Homo sapiens)
- Insulin a chain (2 kDa, Protein from Homo sapiens)
Forbes BE, Safavi-Hemami H, Hill CP, Chou DH
Nat Chem Biol (2022) 18 pp. 511-519 [ DOI: 10.1038/s41589-022-00981-0 Pubmed: 35289328 ]
Image sets:
Cryo-EM structure of an activated Cholecystokinin A receptor (CCKAR)-Gi complex
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7ezh
Q-score: 0.42
Liu Q, Yang D, Zhuang Y, Croll TI, Cai X, Dai A, He X, Duan J, Yin W, Ye C, Zhou F, Wu B, Zhao Q, Xu HE, Wang MW, Jiang Y
Nat Chem Biol (2021) 17 pp. 1238-1244 [ DOI: doi:10.1038/s41589-021-00841-3 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Cryo-em structure of an activated cholecystokinin a receptor (cckar)-gi complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Cholecystokinin receptor type a (47 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from synthetic construct)
- Cholecystokinin-8 (1 kDa, Protein from Homo sapiens)
Cryo-EM structure of an activated Cholecystokinin A receptor (CCKAR)-Gs complex
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7ezk
Q-score: 0.435
Liu Q, Yang D, Zhuang Y, Croll TI, Cai X, Dai A, He X, Duan J, Yin W, Ye C, Zhou F, Wu B, Zhao Q, Xu HE, Wang MW, Jiang Y
Nat Chem Biol (2021) 17 pp. 1238-1244 [ DOI: doi:10.1038/s41589-021-00841-3 ]
- Cryo-em structure of an activated cholecystokinin a receptor (cckar)-gs complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Cholecystokinin receptor type a (47 kDa, Protein from Homo sapiens)
- Chimera of guanine nucleotide-binding protein g(i) subunit alpha-1 and guanine nucleotide-binding protein g(s) subunit alpha isoforms short (41 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Cholecystokinin-8 (1 kDa, Protein from Homo sapiens)
Cryo-EM structure of an activated Cholecystokinin A receptor (CCKAR)-Gq complex
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7ezm
Q-score: 0.486
Liu Q, Yang D, Zhuang Y, Croll TI, Cai X, Dai A, He X, Duan J, Yin W, Ye C, Zhou F, Wu B, Zhao Q, Xu HE, Wang MW, Jiang Y
Nat Chem Biol (2021) 17 pp. 1238-1244 [ DOI: doi:10.1038/s41589-021-00841-3 ]
- Fusion protein of guanine nucleotide-binding protein g(i) subunit alpha-1 and guanine nucleotide-binding protein g(q) subunit alpha-q (41 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Cholecystokinin receptor type a (47 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Cryo-em structure of an activated cholecystokinin a receptor (cckar)-gq complex (Complex from Homo sapiens)
- Scfv16 (26 kDa, Protein from synthetic construct)
- Cholecystokinin-8 (1 kDa, Protein from Homo sapiens)