Cryo-EM structure of the GPR101-Gs complex
Resolution: 2.89 Å
EM Method: Single-particle
Fitted PDBs: 8w8q
Q-score: 0.564
Yang Z, Wang JY, Yang F, Zhu KK, Wang GP, Guan Y, Ning SL, Lu Y, Li Y, Zhang C, Zheng Y, Zhou SH, Wang XW, Wang MW, Xiao P, Yi F, Zhang C, Zhang PJ, Xu F, Liu BH, Zhang H, Yu X, Gao N, Sun JP
Nat Chem Biol (2024) 20 pp. 484-492 [ Pubmed: 37945893 DOI: doi:10.1038/s41589-023-01456-6 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Soluble cytochrome b562,probable g-protein coupled receptor 101 (73 kDa, Protein from Homo sapiens)
- Cryo-em structure of the gpr101-gs complex (Complex from Homo sapiens)
- Nb35 (13 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
Cryo-EM structure of the AA-14-bound GPR101-Gs complex
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8w8r
Q-score: 0.558
Yang Z, Wang JY, Yang F, Zhu KK, Wang GP, Guan Y, Ning SL, Lu Y, Li Y, Zhang C, Zheng Y, Zhou SH, Wang XW, Wang MW, Xiao P, Yi F, Zhang C, Zhang PJ, Xu F, Liu BH, Zhang H, Yu X, Gao N, Sun JP
Nat Chem Biol (2024) 20 pp. 484-492 [ Pubmed: 37945893 DOI: doi:10.1038/s41589-023-01456-6 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1,guanine nucleotide-binding protein g(s) subunit (42 kDa, Protein from Homo sapiens)
- Cryo-em structure of the aa14-bound gpr101-gs complex (Complex from Homo sapiens)
- Scfv16 (30 kDa, Protein from Homo sapiens)
- Probable g-protein coupled receptor 101 (56 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- 1-(4-methylpyridin-2-yl)-3-[3-(trifluoromethyl)phenyl]thiourea (311 Da, Ligand)
Cryo-EM structure of the AA14-bound GPR101 complex
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8w8s
Q-score: 0.471
Cholesterol bound state of mTRPV2
Resolution: 3.17 Å
EM Method: Single-particle
Fitted PDBs: 7xem
Q-score: 0.44
Su N, Zhen W, Zhang H, Xu L, Jin Y, Chen X, Zhao C, Wang Q, Wang X, Li S, Wen H, Yang W, Guo J, Yang F
Nat Chem Biol (2023) 19 pp. 72-80 [ DOI: doi:10.1038/s41589-022-01139-8 Pubmed: 36163384 ]
- Cholesterol (386 Da, Ligand)
- Complex of mtrpv2 and cholesterol (Complex from Mus musculus)
- Transient receptor potential cation channel subfamily v member 2 (86 kDa, Protein from Mus musculus)
- Water (18 Da, Ligand)
MbetaCD treated state of mTRPV2
Resolution: 2.89 Å
EM Method: Single-particle
Fitted PDBs: 7xeo
Q-score: 0.486
Resolution: 2.47 Å
EM Method: Single-particle
Fitted PDBs: 7xer
Q-score: 0.497
Su N, Zhen W, Zhang H, Xu L, Jin Y, Chen X, Zhao C, Wang Q, Wang X, Li S, Wen H, Yang W, Guo J, Yang F
Nat Chem Biol (2023) 19 pp. 72-80 [ DOI: doi:10.1038/s41589-022-01139-8 Pubmed: 36163384 ]
- Cholesterol (386 Da, Ligand)
- Transient receptor potential cation channel subfamily v member 2 (86 kDa, Protein from Mus musculus)
- Mtrpv2_q525t (Cellular component from Mus musculus)
Resolution: 2.77 Å
EM Method: Single-particle
Fitted PDBs: 7xeu
Q-score: 0.5
Su N, Zhen W, Zhang H, Xu L, Jin Y, Chen X, Zhao C, Wang Q, Wang X, Li S, Wen H, Yang W, Guo J, Yang F
Nat Chem Biol (2023) 19 pp. 72-80 [ DOI: doi:10.1038/s41589-022-01139-8 Pubmed: 36163384 ]
- Transient receptor potential cation channel subfamily v member 2 (86 kDa, Protein from Mus musculus)
- Cholesterol (386 Da, Ligand)
- Mtrpv2_e2 (Cellular component from Mus musculus)
Resolution: 3.27 Å
EM Method: Single-particle
Fitted PDBs: 7xev
Q-score: 0.449
Resolution: 2.59 Å
EM Method: Single-particle
Fitted PDBs: 7xew
Q-score: 0.523
Resolution: 2.83 Å
EM Method: Single-particle
Fitted PDBs: 7yep
Q-score: 0.369