Structure of Dimeric HECT E3 Ubiquitin Ligase UBR5
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8c06
Q-score: 0.478
Hehl LA, Horn-Ghetko D, Prabu JR, Vollrath R, Vu DT, Perez Berrocal DA, Mulder MPC, van der Heden van Noort GJ, Schulman BA
Nat Chem Biol (2024) 20 pp. 190-200 [ DOI: doi:10.1038/s41589-023-01414-2 Pubmed: 37620400 ]
- Zinc ion (65 Da, Ligand)
- E3 ubiquitin-protein ligase ubr5 (310 kDa, Protein from Homo sapiens)
- Dimeric hect e3 ubiquitin ligase ubr5 (620 kDa, Complex from Homo sapiens)
Structure of HECT E3 UBR5 forming K48 linked Ubiquitin chains
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8c07
Q-score: 0.416
Hehl LA, Horn-Ghetko D, Prabu JR, Vollrath R, Vu DT, Perez Berrocal DA, Mulder MPC, van der Heden van Noort GJ, Schulman BA
Nat Chem Biol (2024) 20 pp. 190-200 [ DOI: doi:10.1038/s41589-023-01414-2 Pubmed: 37620400 ]
- E3 ubiquitin-protein ligase ubr5 (310 kDa, Protein from Homo sapiens)
- Polyubiquitin-b (8 kDa, Protein from Homo sapiens)
- Polyubiquitin-b (8 kDa, Protein from Homo sapiens)
- Hect e3 ubr5 forming k48 linked ubiquitin chains (620 kDa, Complex from Homo sapiens)
- 5-azanylpentan-2-one (101 Da, Ligand)
Tetrameric HECT E3 Ubiquitin Ligase UBR5
Hehl LA, Horn-Ghetko D, Prabu JR, Vollrath R, Vu DT, Perez Berrocal DA, Mulder MPC, van der Heden van Noort GJ, Schulman BA
Nat Chem Biol (2024) 20 pp. 190-200 [ DOI: doi:10.1038/s41589-023-01414-2 Pubmed: 37620400 ]
- Homo tetramer of hect e3 ubr5 (1 MDa, Complex from Homo sapiens)
Cryo-EM map of ubiquitin-VME bound HECT E3 ligase UBR5
Hehl LA, Horn-Ghetko D, Prabu JR, Vollrath R, Vu DT, Perez Berrocal DA, Mulder MPC, van der Heden van Noort GJ, Schulman BA
Nat Chem Biol (2024) 20 pp. 190-200 [ DOI: doi:10.1038/s41589-023-01414-2 Pubmed: 37620400 ]
Ubiquitin transfer from E2 to E3: UBE2D2-ubiquitin linked to HECT E3 ligase UBR5
Hehl LA, Horn-Ghetko D, Prabu JR, Vollrath R, Vu DT, Perez Berrocal DA, Mulder MPC, van der Heden van Noort GJ, Schulman BA
Nat Chem Biol (2024) 20 pp. 190-200 [ DOI: doi:10.1038/s41589-023-01414-2 Pubmed: 37620400 ]
- Ub (Complex from Homo sapiens)
- Dimeric ubr5 crosslinked to ube2d2~ub (9 kDa, Complex from Homo sapiens)
- Ube2d2 (Complex from Homo sapiens)
Cryo-EM map of HECT E3 ligase UBR5 forming K48 linked ubiquitin chains
Hehl LA, Horn-Ghetko D, Prabu JR, Vollrath R, Vu DT, Perez Berrocal DA, Mulder MPC, van der Heden van Noort GJ, Schulman BA
Nat Chem Biol (2024) 20 pp. 190-200 [ DOI: doi:10.1038/s41589-023-01414-2 Pubmed: 37620400 ]
- Ubiquitin (9 kDa, Complex from Homo sapiens)
- Hect e3 ubr5 forming k48 linked ubiquitin chains (620 kDa, Complex)
Structure of Neddylated CUL5 C-terminal region-RBX2-ARIH2*
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7oni
Q-score: 0.464
Kostrhon S, Prabu JR, Baek K, Horn-Ghetko D, von Gronau S, Klugel M, Basquin J, Alpi AF, Schulman BA
Nat Chem Biol (2021) 17 pp. 1075-1083 [ Pubmed: 34518685 DOI: doi:10.1038/s41589-021-00858-8 ]
- Zinc ion (65 Da, Ligand)
- Cullin-5 (91 kDa, Protein from Homo sapiens)
- Ring-box protein 2 (12 kDa, Protein from Homo sapiens)
- E3 ubiquitin-protein ligase arih2 (57 kDa, Protein from Homo sapiens)
- Neddylated cul5 c-terminal region-rbx2-arih2 (Complex from Homo sapiens)
- Nedd8 (9 kDa, Protein from Homo sapiens)
Structure of Neddylated CRL5Vif-CBFbeta-ARIH2*-APOBEC3C (A3C fullcomplex consensus )
Kostrhon S, Prabu JR, Baek K, Horn-Ghetko D, von Gronau S, Klugel M, Basquin J, Alpi AF, Schulman BA
Nat Chem Biol (2021) 17 pp. 1075-1083 [ Pubmed: 34518685 DOI: doi:10.1038/s41589-021-00858-8 ]
- Arih2 (Complex from Homo sapiens)
- Neddylated cul5 c-terminal region-rbx2-arih2 (Complex)
- Rbx2 (Complex from Homo sapiens)
- Cullin-5 (Complex from Homo sapiens)
- Nedd8 (Complex from Homo sapiens)
Structure of Neddylated CUL5 C-terminal region-RBX2-ARIH2* ( A3G E3-E3 catalytic focused )
Kostrhon S, Prabu JR, Baek K, Horn-Ghetko D, von Gronau S, Klugel M, Basquin J, Alpi AF, Schulman BA
Nat Chem Biol (2021) 17 pp. 1075-1083 [ Pubmed: 34518685 DOI: doi:10.1038/s41589-021-00858-8 ]
- Arih2 (Complex from Homo sapiens)
- Neddylated cul5 c-terminal region-rbx2-arih2 (Complex)
- Rbx2 (Complex from Homo sapiens)
- Cullin-5 (Complex from Homo sapiens)
- Nedd8 (Complex from Homo sapiens)
Structure of Neddylated CRL5Vif-CBFbeta-ARIH2*-APOBEC3C (A3C consensus )
Kostrhon S, Prabu JR, Baek K, Horn-Ghetko D, von Gronau S, Klugel M, Basquin J, Alpi AF, Schulman BA
Nat Chem Biol (2021) 17 pp. 1075-1083 [ Pubmed: 34518685 DOI: doi:10.1038/s41589-021-00858-8 ]
- Arih2 (Complex from Homo sapiens)
- Neddylated cul5 c-terminal region-rbx2-arih2 (Complex)
- Rbx2 (Complex from Homo sapiens)
- Cullin-5 (Complex from Homo sapiens)
- Nedd8 (Complex from Homo sapiens)