Cryo-EM structure of the relaxin receptor RXFP1 in complex with heterotrimeric Gs
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7tmw
Q-score: 0.336
Erlandson SC, Rawson S, Osei-Owusu J, Brock KP, Liu X, Paulo JA, Mintseris J, Gygi SP, Marks DS, Cong X, Kruse AC
Nat Chem Biol (2023) 19 pp. 1013-1021 [ DOI: doi:10.1038/s41589-023-01321-6 Pubmed: 37081311 ]
- Camelid antibody vhh fragment nb35 (Complex from Lama glama)
- Camelid antibody vhh fragment nb35 (17 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Complex of the relaxin receptor rxfp1 and heterotrimeric gs (180 kDa, Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1, guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from Homo sapiens)
- Relaxin receptor 1, guanine nucleotide-binding protein g(s) subunit alpha isoforms short fusion (113 kDa, Protein from Homo sapiens)
- Relaxin receptor 1, guanine nucleotide-binding protein g(s) subunit alpha isoforms short fusion (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
Infectious mouse-adapted ME7 scrapie prion fibril purified from terminally-infected mouse brains
Resolution: 2.6 Å
EM Method: Helical reconstruction
Fitted PDBs: 8a00
Q-score: 0.633
Manka SW, Wenborn A, Betts J, Joiner S, Saibil HR, Collinge J, Wadsworth JDF
Nat Chem Biol (2023) 19 pp. 607-613 [ DOI: doi:10.1038/s41589-022-01229-7 Pubmed: 36646960 ]
- Major prion protein (15 kDa, Protein from Mus musculus)
- Amyloid fibril of prion protein (Complex from Mus musculus)
Harris JA, Faust B, Gondin AB, Dämgen MA, Suomivuori CM, Veldhuis NA, Cheng Y, Dror RO, Thal DM, Manglik A
Nat Chem Biol (2021) 18 pp. 109-115 [ Pubmed: 34711980 DOI: 10.1038/s41589-021-00890-8 ]
Image sets:
Ex4-D-Ala bound to the glucagon-like peptide-1 receptor/g protein complex (conformer 2)
Resolution: 2.51 Å
EM Method: Single-particle
Fitted PDBs: 7s3i
Q-score: 0.58
Cary BP, Deganutti G, Zhao P, Truong TT, Piper SJ, Liu X, Belousoff MJ, Danev R, Sexton PM, Wootten D, Gellman SH
Nat Chem Biol (2022) 18 pp. 256-263 [ Pubmed: 34937906 DOI: doi:10.1038/s41589-021-00945-w ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Nb35 (13 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Glucagon-like peptide 1 receptor (56 kDa, Protein from Homo sapiens)
- Glp-1r bound to ex4-d-ala, g alpha s, g beta-1, g gamma-2, and nb35 (Complex from Homo sapiens)
SARS CoV2 Spike ectodomain with engineered trimerized VH binder
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7jwb
Q-score: 0.232
Bracken CJ, Lim SA, Solomon P, Rettko NJ, Nguyen DP, Zha BS, Schaefer K, Byrnes JR, Zhou J, Lui I, Liu J, Pance K, Zhou XX, Leung KK, Wells JA
Nat Chem Biol (2021) 17 pp. 113-121 [ DOI: doi:10.1038/s41589-020-00679-1 Pubmed: 33082574 ]
- Engineered trimerized vh domain (Complex from Homo sapiens)
- Spike glycoprotein (133 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Sars cov2 spike ectodomain (Complex from Severe acute respiratory syndrome coronavirus 2)
- Complex of sars cov2 spike ectodomain with engineered trimerized vh domain (445 kDa, Complex)
- Autonomous human heavy chain variable domain (44 kDa, Protein from Homo sapiens)