Structure of AT118-H Nanobody Antagonist in Complex with the Angiotensin II Type I Receptor
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8th3
Q-score: 0.532
Skiba MA, Sterling SM, Rawson S, Zhang S, Xu H, Jiang H, Nemeth GR, Gilman MSA, Hurley JD, Shen P, Staus DP, Kim J, McMahon C, Lehtinen MK, Rockman HA, Barth P, Wingler LM, Kruse AC
Nat Chem Biol (2024) 20 pp. 1577-1585 [ Pubmed: 38744986 DOI: doi:10.1038/s41589-024-01620-6 ]
- At118-h nanobody antagonist in complex with the angiotensin ii type i receptor bril fusion, anti-bril fab, and anti-fab nanobody (Complex from Homo sapiens)
- Bag2 anti-bril fab heavy chain (24 kDa, Protein from synthetic construct)
- At118-h nanobody, type-1 angiotensin ii receptor, soluble cytochrome b562 complex (65 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Bag2 anti-bril fab light chain (23 kDa, Protein from synthetic construct)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8th4
Q-score: 0.495
Skiba MA, Sterling SM, Rawson S, Zhang S, Xu H, Jiang H, Nemeth GR, Gilman MSA, Hurley JD, Shen P, Staus DP, Kim J, McMahon C, Lehtinen MK, Rockman HA, Barth P, Wingler LM, Kruse AC
Nat Chem Biol (2024) 20 pp. 1577-1585 [ Pubmed: 38744986 DOI: doi:10.1038/s41589-024-01620-6 ]
- Bag2 anti-bril fab heavy chain (24 kDa, Protein from synthetic construct)
- Type-1 angiotensin ii receptor soluble cytochrome b562 complex (49 kDa, Protein from Homo sapiens)
- At118-l nanobody antagonist in complex with the angiotensin ii type i receptor bril fusion protein, anti-bril fab, anti-fab nanobody, and losartan (Complex from Homo sapiens)
- [2-butyl-5-chloranyl-3-[[4-[2-(2h-1,2,3,4-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol (422 Da, Ligand)
- At118-l nanobody (15 kDa, Protein from synthetic construct)
- Bag2 anti-bril fab light chain (23 kDa, Protein from synthetic construct)
Complex Structure of Arginine Kinase McsB and McsA from Staphylococcus aureus
Resolution: 3.41 Å
EM Method: Single-particle
Fitted PDBs: 8gqd
Q-score: 0.359
Lu K, Luo B, Tao X, Luo Y, Ao M, Zheng B, Xu X, Ma X, Niu J, Li H, Xie Y, Zhao Z, Zheng P, Wang G, Gao S, Wang C, Xia W, Su Z, Mao ZW
Nat Chem Biol (2024) [ DOI: doi:10.1038/s41589-024-01720-3 Pubmed: 39232187 ]
- Protein-arginine kinase (38 kDa, Protein from Staphylococcus aureus)
- Mcsa-mcsb complex (Complex from Staphylococcus aureus)
- Protein-arginine kinase activator protein (6 kDa, Protein from Staphylococcus aureus)
- Zinc ion (65 Da, Ligand)
human KCNQ2-CaM-Ebio1 complex in the presence of PIP2
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8ijk
Q-score: 0.383
Zhang S, Ma D, Wang K, Li Y, Yang Z, Li X, Li J, He J, Mei L, Ye Y, Chen Z, Shen J, Hou P, Guo J, Zhang Q, Yang H
Nat Chem Biol (2024) 20 pp. 847-856 [ Pubmed: 38167918 DOI: doi:10.1038/s41589-023-01515-y ]
- N-(1,2-dihydroacenaphthylen-5-yl)-4-fluoranyl-benzamide (291 Da, Ligand)
- Human kcnq2-cam-ebio1 complex in the presence of pip2 (Complex from Homo sapiens)
- Calmodulin-1 (16 kDa, Protein from Homo sapiens)
- Potassium voltage-gated channel subfamily kqt member 2 (73 kDa, Protein from Homo sapiens)
human KCNQ2-CaM-Ebio1-S1 complex in the presence of PIP2
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8x43
Q-score: 0.328
Zhang S, Ma D, Wang K, Li Y, Yang Z, Li X, Li J, He J, Mei L, Ye Y, Chen Z, Shen J, Hou P, Guo J, Zhang Q, Yang H
Nat Chem Biol (2024) 20 pp. 847-856 [ Pubmed: 38167918 DOI: doi:10.1038/s41589-023-01515-y ]
- Calmodulin-1 (16 kDa, Protein from Homo sapiens)
- Human kcnq2-cam-ebio1-s1 complex in the presence of pip2 (Cellular component from Homo sapiens)
- N-(4-azanyl-1,2-dihydroacenaphthylen-5-yl)-4-fluoranyl-benzamide (306 Da, Ligand)
- Potassium voltage-gated channel subfamily kqt member 2 (73 kDa, Protein from Homo sapiens)
Aplysia californica FaNaC in apo state
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7yvc
Q-score: 0.532
Liu F, Dang Y, Li L, Feng H, Li J, Wang H, Zhang X, Zhang Z, Ye S, Tian Y, Chen Q
Nat Chem Biol (2023) 19 pp. 1276-1285 [ Pubmed: 37550431 DOI: doi:10.1038/s41589-023-01401-7 ]
- Fmrfamide-gated na+ channel (76 kDa, Protein from Aplysia californica)
- Trimeric fmrfamide activated sodium channel from aplysia californica (acfanac) (73 kDa, Complex from Aplysia californica)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Calcium ion (40 Da, Ligand)
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8hk3
Q-score: 0.438
Wang Y, Liu W, Xu Y, He X, Yuan Q, Luo P, Fan W, Zhu J, Zhang X, Cheng X, Jiang Y, Xu HE, Zhuang Y
Nat Chem Biol (2023) 19 pp. 1351-1360 [ Pubmed: 37169960 DOI: doi:10.1038/s41589-023-01339-w ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Scfv16 (26 kDa, Protein from Rattus norvegicus)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- C3a anaphylatoxin chemotactic receptor (53 kDa, Protein from Homo sapiens)
- C3ar-gi-apo protein complex (160 kDa, Complex from Homo sapiens)
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8hk5
Q-score: 0.456
Wang Y, Liu W, Xu Y, He X, Yuan Q, Luo P, Fan W, Zhu J, Zhang X, Cheng X, Jiang Y, Xu HE, Zhuang Y
Nat Chem Biol (2023) 19 pp. 1351-1360 [ Pubmed: 37169960 DOI: doi:10.1038/s41589-023-01339-w ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- Complement c5 (8 kDa, Protein from Homo sapiens)
- Palmitic acid (256 Da, Ligand)
- C5ar1-gi-c5a protein complex (160 kDa, Complex from Homo sapiens)
- Guanine nucleotide-binding protein subunit gamma (7 kDa, Protein from Bos taurus)
- C5a anaphylatoxin chemotactic receptor 1 (39 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)