Mahalingan KK, Grotjahn DA, Li Y, Lander GC, Zehr EA, Roll-Mecak A
Nat Chem Biol (2024) [ DOI: doi:10.1038/s41589-024-01599-0 Pubmed: 38658656 ]
- Tubulin alpha-1b chain (Protein from Homo sapiens)
- Tubulin polyglutamylase ttll6 (Protein from Mus musculus)
- Ttll6 bound to unmodified human microtubules (300 kDa, Complex)
- Tubulin beta-i/ivb chain (Protein from Homo sapiens)
- Tubulin polyglutamylase ttll6 (Complex from Mus musculus)
- Tubulin alpha-1b, betai and betaivb (Complex from Homo sapiens)
Composite map of TTLL6 bound to unmodified human microtubule
Mahalingan KK, Grotjahn DA, Li Y, Lander GC, Zehr EA, Roll-Mecak A
Nat Chem Biol (2024) 20 pp. 1493-1504 [ DOI: doi:10.1038/s41589-024-01599-0 Pubmed: 38658656 ]
- Tubulin alpha-1b chain (Macromolecule from Homo sapiens)
- Ttll6 bound to unmodified human microtubule (100 kDa, Complex)
- Tubulin polyglutamylase ttll6 in complex with unmodified human microtubule (Complex from Mus musculus)
- Alpha1b and betai/betaivb microtubule (Complex from Homo sapiens)
- Tubulin beta chain (Macromolecule from Homo sapiens)
- Tubulin polyglutamylase ttll6 (Macromolecule from Mus musculus)
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8t42
Q-score: 0.395
Mahalingan KK, Grotjahn DA, Li Y, Lander GC, Zehr EA, Roll-Mecak A
Nat Chem Biol (2024) 20 pp. 1493-1504 [ DOI: doi:10.1038/s41589-024-01599-0 Pubmed: 38658656 ]
- Phosphomethylphosphonic acid guanylate ester (521 Da, Ligand)
- Tubulin beta chain (49 kDa, Protein from Homo sapiens)
- Tubulin alpha-1b chain (50 kDa, Protein from Homo sapiens)
- Ttll6 bound to unmodified human microtubules (300 kDa, Complex)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Tubulin polyglutamylase ttll6 (59 kDa, Protein from Mus musculus)
- Tubulin alpha-1b chain, tubulin betai chain (Complex from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Tubulin polyglutamylase ttll6 (Complex from Mus musculus)
hPAD4 bound to Activating Fab hA362
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8smk
Q-score: 0.419
Zhou X, Kong S, Maker A, Remesh SG, Leung KK, Verba KA, Wells JA
Nat Chem Biol (2024) 20 pp. 742-750 [ DOI: doi:10.1038/s41589-023-01535-8 Pubmed: 38308046 ]
- Protein-arginine deiminase type-4 (77 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Activating fab 362 heavy chain (24 kDa, Protein from Homo sapiens)
- Hpad4 bound to activating fab ha362 (248 kDa, Complex from Homo sapiens)
- Activating fab 362 light chain (23 kDa, Protein from Homo sapiens)
hPAD4 bound to inhibitory Fab hI365
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8sml
Q-score: 0.399
Zhou X, Kong S, Maker A, Remesh SG, Leung KK, Verba KA, Wells JA
Nat Chem Biol (2024) 20 pp. 742-750 [ DOI: doi:10.1038/s41589-023-01535-8 Pubmed: 38308046 ]
- Protein-arginine deiminase type-4 (77 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Fab hi365 light chain (23 kDa, Protein from Homo sapiens)
- Hpad4 bound to inhibitory fab hi365 (248 kDa, Complex from Homo sapiens)
- Fab hi365 heavy chain (24 kDa, Protein from Homo sapiens)
Cryo-EM structure of the AA-14-bound GPR101-Gs complex
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8w8r
Q-score: 0.558
Yang Z, Wang JY, Yang F, Zhu KK, Wang GP, Guan Y, Ning SL, Lu Y, Li Y, Zhang C, Zheng Y, Zhou SH, Wang XW, Wang MW, Xiao P, Yi F, Zhang C, Zhang PJ, Xu F, Liu BH, Zhang H, Yu X, Gao N, Sun JP
Nat Chem Biol (2024) 20 pp. 484-492 [ Pubmed: 37945893 DOI: doi:10.1038/s41589-023-01456-6 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1,guanine nucleotide-binding protein g(s) subunit (42 kDa, Protein from Homo sapiens)
- Cryo-em structure of the aa14-bound gpr101-gs complex (Complex from Homo sapiens)
- Scfv16 (30 kDa, Protein from Homo sapiens)
- Probable g-protein coupled receptor 101 (56 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- 1-(4-methylpyridin-2-yl)-3-[3-(trifluoromethyl)phenyl]thiourea (311 Da, Ligand)
Cryo-EM structure of the AA14-bound GPR101 complex
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8w8s
Q-score: 0.471
SARS CoV2 Spike ectodomain with engineered trimerized VH binder
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7jwb
Q-score: 0.232
Bracken CJ, Lim SA, Solomon P, Rettko NJ, Nguyen DP, Zha BS, Schaefer K, Byrnes JR, Zhou J, Lui I, Liu J, Pance K, Zhou XX, Leung KK, Wells JA
Nat Chem Biol (2021) 17 pp. 113-121 [ DOI: doi:10.1038/s41589-020-00679-1 Pubmed: 33082574 ]
- Engineered trimerized vh domain (Complex from Homo sapiens)
- Spike glycoprotein (133 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Sars cov2 spike ectodomain (Complex from Severe acute respiratory syndrome coronavirus 2)
- Complex of sars cov2 spike ectodomain with engineered trimerized vh domain (445 kDa, Complex)
- Autonomous human heavy chain variable domain (44 kDa, Protein from Homo sapiens)