The cryo-EM structure of TdpAB in complex with AMPPNP and PT-DNA
An T, Tan Q, Jiang L, Liu L, Jiang X, Liu L, Chang X, Tian X, Deng Z, Gao S, Wang L, Chen S
Nat Chem Biol (2025) [ Pubmed: 39820821 DOI: doi:10.1038/s41589-024-01832-w ]
- Tdpa (66 kDa, Protein from Thermus antranikianii DSM 12462)
- Tdpb (42 kDa, Protein from Thermus antranikianii DSM 12462)
- Tdpab in complex with amppnp and pt-dna (Complex from Thermus antranikianii DSM 12462)
- Dna (5'-d(p*tp*tp*gp*cp*ap*ap*ap*ap*gp*gp*gp*c)-3') (3 kDa, DNA from Thermus antranikianii DSM 12462)
- Dna (5'-d(p*gp*cp*cp*cp*tp*tp*tp*tp*gp*cp*ap*a)-3') (3 kDa, DNA from Thermus antranikianii DSM 12462)
- Phosphoaminophosphonic acid-adenylate ester (506 Da, Ligand)
human KCNQ2-CaM-Ebio1 complex in the presence of PIP2
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8ijk
Q-score: 0.383
Zhang S, Ma D, Wang K, Li Y, Yang Z, Li X, Li J, He J, Mei L, Ye Y, Chen Z, Shen J, Hou P, Guo J, Zhang Q, Yang H
Nat Chem Biol (2024) 20 pp. 847-856 [ Pubmed: 38167918 DOI: doi:10.1038/s41589-023-01515-y ]
- N-(1,2-dihydroacenaphthylen-5-yl)-4-fluoranyl-benzamide (291 Da, Ligand)
- Human kcnq2-cam-ebio1 complex in the presence of pip2 (Complex from Homo sapiens)
- Calmodulin-1 (16 kDa, Protein from Homo sapiens)
- Potassium voltage-gated channel subfamily kqt member 2 (73 kDa, Protein from Homo sapiens)
human KCNQ2-CaM-Ebio1-S1 complex in the presence of PIP2
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8x43
Q-score: 0.328
Zhang S, Ma D, Wang K, Li Y, Yang Z, Li X, Li J, He J, Mei L, Ye Y, Chen Z, Shen J, Hou P, Guo J, Zhang Q, Yang H
Nat Chem Biol (2024) 20 pp. 847-856 [ Pubmed: 38167918 DOI: doi:10.1038/s41589-023-01515-y ]
- Calmodulin-1 (16 kDa, Protein from Homo sapiens)
- Human kcnq2-cam-ebio1-s1 complex in the presence of pip2 (Cellular component from Homo sapiens)
- N-(4-azanyl-1,2-dihydroacenaphthylen-5-yl)-4-fluoranyl-benzamide (306 Da, Ligand)
- Potassium voltage-gated channel subfamily kqt member 2 (73 kDa, Protein from Homo sapiens)
Cryo-EM structure of the beta2AR-mBRIL/1b3 Fab/Glue complex with a partial agonist
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8jj8
Q-score: 0.453
Guo Q, He B, Zhong Y, Jiao H, Ren Y, Wang Q, Ge Q, Gao Y, Liu X, Du Y, Hu H, Tao Y
Nat Chem Biol (2024) 20 pp. 74-82 [ Pubmed: 37580554 DOI: doi:10.1038/s41589-023-01389-0 ]
- ~{n}-[5-[(1~{r})-2-[[(2~{r})-1-(4-methoxyphenyl)propan-2-yl]amino]-1-oxidanyl-ethyl]-2-oxidanyl-phenyl]methanamide (344 Da, Ligand)
- Beta-2 adrenergic receptor,soluble cytochrome b562 (51 kDa, Protein from Homo sapiens)
- Cryo-em structure of the beta2ar-mbril/1b3 fab/glue complex with a partial agonist (Complex from Homo sapiens)
cryo-EM structure of the beta2-AR-mBRIL/1b3 Fab/Glue complex with a full agonist
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8jjl
Q-score: 0.447
Guo Q, He B, Zhong Y, Jiao H, Ren Y, Wang Q, Ge Q, Gao Y, Liu X, Du Y, Hu H, Tao Y
Nat Chem Biol (2024) 20 pp. 74-82 [ Pubmed: 37580554 DOI: doi:10.1038/s41589-023-01389-0 ]
- Chimeric beta-2ar adrenergic receptor (Complex from Homo sapiens)
- Beta-2 adrenergic receptor,soluble cytochrome b562 (51 kDa, Protein from Homo sapiens)
- Olodaterol (386 Da, Ligand)
Cryo-EM structure of the beta2AR-mBRIL/1b3 Fab/Glue complex with an antagonist
Aplysia californica FaNaC in apo state
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7yvc
Q-score: 0.532
Liu F, Dang Y, Li L, Feng H, Li J, Wang H, Zhang X, Zhang Z, Ye S, Tian Y, Chen Q
Nat Chem Biol (2023) 19 pp. 1276-1285 [ Pubmed: 37550431 DOI: doi:10.1038/s41589-023-01401-7 ]
- Fmrfamide-gated na+ channel (76 kDa, Protein from Aplysia californica)
- Trimeric fmrfamide activated sodium channel from aplysia californica (acfanac) (73 kDa, Complex from Aplysia californica)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Calcium ion (40 Da, Ligand)