Structure of the native glutamine synthetase in the adult cortex and hippocampus
Zhang M, Feng J, Xie C, Song N, Jin C, Wang J, Zhao Q, Zhang L, Wang B, Sun Y, Guo F, Li Y, Zhu S
Cell (2025) [ DOI: doi:10.1016/j.cell.2025.01.004 Pubmed: 39855198 ]
- Glutamine synthetase (42 kDa, Protein from Rattus norvegicus)
- Decamer of glutamine synthetase from rat brain (600 MDa, Complex from Rattus norvegicus)
Structure of native tri-heteromeric GluN1-GluN2A-GluN2B NMDA receptor in rat cortex and hippocampus
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 8xlk
Q-score: 0.278
Zhang M, Feng J, Xie C, Song N, Jin C, Wang J, Zhao Q, Zhang L, Wang B, Sun Y, Guo F, Li Y, Zhu S
Cell (2025) [ Pubmed: 39855198 DOI: doi:10.1016/j.cell.2025.01.004 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Nmda receptor (Complex)
- Glutamate receptor ionotropic, nmda 2b (166 kDa, Protein from Rattus norvegicus)
- Heavy chain of glun2a fab, 28c (24 kDa, Protein from Mus musculoides)
- Native tri-heteromeric glun1-glun2a-glun2b nmda receptor in rat cortex and hippocampus (Tissue from Rattus norvegicus)
- Glutamate receptor ionotropic, nmda 1 (105 kDa, Protein from Rattus norvegicus)
- Light chain of glun2b fab2 (28 kDa, Protein from Mus musculoides)
- Fab 28c (Complex)
- Fab (Complex from Mus musculoides)
- Heavy chain of glun1 fab, 4f11 (15 kDa, Protein from Mus musculoides)
- Light chain of glun2a fab, 28c (22 kDa, Protein from Mus musculoides)
- (2r)-4-(3-phosphonopropyl)piperazine-2-carboxylic acid (252 Da, Ligand)
- Fab 4f11 (Complex)
- Glutamate receptor ionotropic, nmda 2a (165 kDa, Protein from Rattus norvegicus)
- Light chain of glun1 fab, 4f11 (13 kDa, Protein from Mus musculoides)
- Fab2 (Complex)
- Heavy chain of glun2b fab2 (26 kDa, Protein from Mus musculoides)
Structure of native di-heteromeric GluN1-GluN2B NMDA receptor in rat cortex and hippocampus
Resolution: 5.4 Å
EM Method: Single-particle
Fitted PDBs: 9jnn
Q-score: 0.183
Zhang M, Feng J, Xie C, Song N, Jin C, Wang J, Zhao Q, Zhang L, Wang B, Sun Y, Guo F, Li Y, Zhu S
Cell (2025) [ Pubmed: 39855198 DOI: doi:10.1016/j.cell.2025.01.004 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Light chain of glun2b fab2 (11 kDa, Protein from Mus musculus)
- Native di-heteromeric glun1-glun2b nmda receptor in rat cortex and hippocampus (Tissue)
- Glutamate receptor ionotropic, nmda 2b (91 kDa, Protein from Rattus norvegicus)
- Fab (Complex from Mus musculus)
- Glutamate receptor ionotropic, nmda 1 (91 kDa, Protein from Rattus norvegicus)
- Light chain of glun1 fab, 4f11 (11 kDa, Protein from Mus musculus)
- Heavy chain of glun2b fab2 (12 kDa, Protein from Mus musculus)
- (2r)-4-(3-phosphonopropyl)piperazine-2-carboxylic acid (252 Da, Ligand)
- Fab 4f11 (Complex)
- Nmda receptor (Complex from Rattus norvegicus)
- Heavy chain of glun1 fab, 4f11 (13 kDa, Protein from Mus musculus)
- Fab2 (Complex)
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 8y1v
Q-score: 0.333
To Be Published
- Isoform 6 of glutamate receptor ionotropic, nmda 1 (97 kDa, Protein from Homo sapiens)
- Glutamate receptor ionotropic, nmda 2d (99 kDa, Protein from Homo sapiens)
- (2~{r},3~{s},4~{s},5~{r},6~{r})-2-(hydroxymethyl)-6-[(2~{s})-2-methyl-4-[(1~{r},2~{r},4~{s},6~{s},7~{s},8~{r},9~{s},12~{s},13~{r},16~{s},18~{r})-7,9,13,18-tetramethyl-16-oxidanyl-5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icosan-6-yl]butoxy]oxane-3,4,5-triol (592 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- N-methyl-d-aspartate receptors (400 MDa, Complex from Homo sapiens)
Resolution: 3.14 Å
EM Method: Single-particle
Fitted PDBs: 8w2p
Q-score: 0.394
Shen BW, Heiter D, Xu S, Stoddard BL
To Be Published
- Water (18 Da, Ligand)
- Quaternary complex of rm, s and dna complex (2 MDa, Complex from Geobacillus stearothermophilus)
- Calcium ion (40 Da, Ligand)
- S.bsaxi (55 kDa, Protein from Geobacillus stearothermophilus)
- Site-specific dna-methyltransferase (adenine-specific) (107 kDa, Protein from Geobacillus stearothermophilus)
- S-adenosyl-l-homocysteine (384 Da, Ligand)
- Dna (41-mer) top strand of bsaxi cognate dna substrate (16 kDa, DNA from Geobacillus stearothermophilus)
- S-adenosylmethionine (398 Da, Ligand)
- Dna (41-mer) complementary strand of bsaxi dna substrate (15 kDa, DNA from Geobacillus stearothermophilus)
Resolution: 3.06 Å
EM Method: Single-particle
Fitted PDBs: 8w2q
Q-score: 0.396
Shen BW, Heiter D, Xu S, Stoddard BL
To Be Published
- Quaternary complex of rm, s and dna complex (2 MDa, Complex from Geobacillus stearothermophilus)
- Dna (41-mer) (15 kDa, DNA from Geobacillus stearothermophilus)
- Dna (41-mer) (16 kDa, DNA from Geobacillus stearothermophilus)
- S.bsaxi (55 kDa, Protein from Geobacillus stearothermophilus)
- S-adenosyl-l-homocysteine (384 Da, Ligand)
- Rm.bsaxi (107 kDa, Protein from Geobacillus stearothermophilus)
- S-adenosylmethionine (398 Da, Ligand)
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 7yff
Q-score: 0.445
Zhang J, Zhang M, Wang Q, Wen H, Liu Z, Wang F, Wang Y, Yao F, Song N, Kou Z, Li Y, Guo F, Zhu S
Nat Struct Mol Biol (2023) 30 pp. 629-639 [ Pubmed: 36959261 DOI: doi:10.1038/s41594-023-00959-z ]
- (2r)-4-(3-phosphonopropyl)piperazine-2-carboxylic acid (252 Da, Ligand)
- Glycine (75 Da, Ligand)
- Glutamate receptor ionotropic, nmda 1 (94 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Nmda receptor with nmda 1 incorperated with nmda 2d (384 MDa, Complex from Homo sapiens)
- Glutamate receptor ionotropic, nmda 2d (97 kDa, Protein from Homo sapiens)
Structure of GluN1a-GluN2D NMDA receptor in complex with agonists glycine and glutamate.
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 7yfl
Q-score: 0.404
Zhang J, Zhang M, Wang Q, Wen H, Liu Z, Wang F, Wang Y, Yao F, Song N, Kou Z, Li Y, Guo F, Zhu S
Nat Struct Mol Biol (2023) 30 pp. 629-639 [ Pubmed: 36959261 DOI: doi:10.1038/s41594-023-00959-z ]
- Glycine (75 Da, Ligand)
- Glutamate receptor ionotropic, nmda 1 (95 kDa, Protein from Homo sapiens)
- Glutamic acid (147 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Nmda receptor with nmda 1 incorperated with nmda 2d (384 MDa, Complex from Homo sapiens)
- Glutamate receptor ionotropic, nmda 2d (97 kDa, Protein from Homo sapiens)