Cryo-EM structure of human angiotensin receptor AT1R in complex Gq proteins and Sar1-AngII
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7f6g
Q-score: 0.504
Zhang D, Liu Y, Zaidi SA, Xu L, Zhan Y, Chen A, Guo J, Huang XP, Roth BL, Katritch V, Cherezov V, Zhang H
EMBO J (2023) 42 pp. e112940-e112940 [ DOI: doi:10.15252/embj.2022112940 Pubmed: 37038975 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sar1-angii (1 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (9 kDa, Protein from Homo sapiens)
- Angiotensin receptor at1r in complex with gq proteins and sar1-angii (168 kDa, Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(q) subunit alpha (43 kDa, Protein from Homo sapiens)
- Angiotensin receptor at1r (81 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7w3z
Q-score: 0.51
Peng S, Zhan Y, Zhang D, Ren L, Chen A, Chen ZF, Zhang H
PNAS (2023) 120 pp. e2216230120-e2216230120 [ DOI: doi:10.1073/pnas.2216230120 Pubmed: 36724251 ]
- Maltodextrin-binding protein,gastrin-releasing peptide receptor (99 kDa, Protein from Homo sapiens)
- Scfv16 (32 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (41 kDa, Protein from Homo sapiens)
- Human gastrin releasing peptide receptor in complex with the agonist gastrin releasing peptide and gq heterotrimers and scfv16 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (9 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(q) subunit alpha (41 kDa, Protein from Homo sapiens)
- Gastrin releasing peptide prgnhwavghlm(nh2) (1 kDa, Protein from Homo sapiens)
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7w40
Q-score: 0.437
Peng S, Zhan Y, Zhang D, Ren L, Chen A, Chen ZF, Zhang H
PNAS (2023) 120 pp. e2216230120-e2216230120 [ DOI: doi:10.1073/pnas.2216230120 Pubmed: 36724251 ]
- Maltodextrin-binding protein,gastrin-releasing peptide receptor (99 kDa, Protein from Homo sapiens)
- Scfv16 (32 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (41 kDa, Protein from Homo sapiens)
- Bombesin (1 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (9 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(q) subunit alpha (41 kDa, Protein from Homo sapiens)
- Peptide receptor in complex with the agonist bombesin (6-14) [d-phe6, beta-ala11, phe13, nle14] and gq heterotrimers and scfv16 (Complex from Homo sapiens)
Cryo-EM structure of human bradykinin receptor BK2R in complex Gq proteins and bradykinin
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7f6h
Q-score: 0.554
Shen J, Zhang D, Fu Y, Chen A, Yang X, Zhang H
Nat Commun (2022) 13 pp. 714-714 [ Pubmed: 35132089 DOI: doi:10.1038/s41467-022-28399-1 ]
- Bradykinin receptor bk2r (86 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (9 kDa, Protein from Homo sapiens)
- Bradykinin (1 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(q) subunit alpha (43 kDa, Protein from Homo sapiens)
- Bradykinin receptor bk2rr in complex with gq proteins and bradykinin (173 kDa, Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
Cryo-EM structure of human bradykinin receptor BK2R in complex Gq proteins and kallidin
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 7f6i
Q-score: 0.559
Shen J, Zhang D, Fu Y, Chen A, Yang X, Zhang H
Nat Commun (2022) 13 pp. 714-714 [ Pubmed: 35132089 DOI: doi:10.1038/s41467-022-28399-1 ]
- Bradykinin receptor bk2r (86 kDa, Protein from Homo sapiens)
- Kallidin (1 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (9 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(q) subunit alpha (43 kDa, Protein from Homo sapiens)
- Bradykinin receptor bk2rr in complex with gq proteins and kallidin (173 kDa, Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)