CasA mediates Cas3-catalyzed target degradation during CRISPR RNA-guided interference
Hochstrasser ML, Taylor DW, Bhat P, Guegler CK, Sternberg SH, Nogales E, Doudna JA
PNAS (2014) 111 pp. 6618-6623 [ DOI: doi:10.1073/pnas.1405079111 Pubmed: 24748111 ]
- Crispr system cascade subunit casb (18 kDa, Protein from Escherichia coli K-12)
- Cascade bound to a 72 bp target dsdna (443 kDa, Sample)
- Crispr system cascade subunit casa (55 kDa, Protein from Escherichia coli K-12)
- R44 crispr rna (18 kDa, RNA from Escherichia coli K-12)
- Crispr system cascade subunit casc (40 kDa, Protein from Escherichia coli K-12)
- Crispr system cascade subunit casd (25 kDa, Protein from Escherichia coli K-12)
- Crispr system cascade subunit case (22 kDa, Protein from Escherichia coli K-12)
- 72 bp dsdna target with r44 protospacer (44 kDa, DNA from Enterobacteria phage P7)
CasA mediates Cas3-catalyzed target degradation during CRISPR RNA-guided interference
Hochstrasser ML, Taylor DW, Bhat P, Guegler CK, Sternberg SH, Nogales E, Doudna JA
PNAS (2014) 111 pp. 6618-6623 [ DOI: doi:10.1073/pnas.1405079111 Pubmed: 24748111 ]
- Crispr system cascade subunit casb (18 kDa, Protein from Escherichia coli K-12)
- Crispr system cascade subunit casa (55 kDa, Protein from Escherichia coli K-12)
- R44 crispr rna (18 kDa, RNA from Escherichia coli K-12)
- Cas3 bound to dsdna-cascade (543 kDa, Sample)
- Crispr-associated endonuclease/helicase cas3 (100 kDa, Protein from Escherichia coli K-12)
- Crispr system cascade subunit casc (40 kDa, Protein from Escherichia coli K-12)
- Crispr system cascade subunit casd (25 kDa, Protein from Escherichia coli K-12)
- Crispr system cascade subunit case (22 kDa, Protein from Escherichia coli K-12)
- 72 bp dsdna target with r44 protospacer (44 kDa, DNA from Enterobacteria phage P7)
Structures of Cas9 endonucleases reveal RNA-mediated conformational activation
Jinek M, Jiang F, Taylor DW, Sternberg SH, Kaya E, Ma E, Anders C, Hauer M, Zhou K, Lin S, Kaplan M, Iavarone AT, Charpentier E, Nogales E, Doudna JA
Science (2014) 343 pp. 1247997- [ DOI: doi:10.1126/science.1247997 Pubmed: 24505130 ]
- Apo-cas9 (160 kDa, Sample)
- Crispr-associated endonuclease cas9 (159 kDa, Protein from Streptococcus pyogenes)
Structures of Cas9 endonucleases reveal RNA-mediated conformational activation
Jinek M, Jiang F, Taylor DW, Sternberg SH, Kaya E, Ma E, Anders C, Hauer M, Zhou K, Lin S, Kaplan M, Iavarone AT, Charpentier E, Nogales E, Doudna JA
Science (2014) 343 pp. 1247997- [ DOI: doi:10.1126/science.1247997 Pubmed: 24505130 ]
- Crispr rna (14 kDa, RNA from Streptococcus pyogenes)
- Cas9 loaded with crrna:tracrrna (196 kDa, Sample)
- Trans-activating crispr rna (24 kDa, RNA from Streptococcus pyogenes)
- Crispr-associated endonuclease cas9 (159 kDa, Protein from Streptococcus pyogenes)
Structures of Cas9 endonucleases reveal RNA-mediated conformational activation
Jinek M, Jiang F, Taylor DW, Sternberg SH, Kaya E, Ma E, Anders C, Hauer M, Zhou K, Lin S, Kaplan M, Iavarone AT, Charpentier E, Nogales E, Doudna JA
Science (2014) 343 pp. 1247997- [ DOI: doi:10.1126/science.1247997 Pubmed: 24505130 ]
- Crispr-associated endonuclease cas9 (159 kDa, Protein from Streptococcus pyogenes)
- Crispr rna (14 kDa, RNA from Streptococcus pyogenes)
- 55 bp dna duplex non-target strand (17 kDa, DNA from Enterobacteria phage lambda)
- Cas9 loaded with crrna:tracrrna and bound to target dna duplex (230 kDa, Sample)
- 55 bp dna duplex target strand (17 kDa, DNA from Enterobacteria phage lambda)
- Trans-activating crispr rna (24 kDa, RNA from Streptococcus pyogenes)