RNA priming complex of Human polymerase alpha-primase (Conformation 2)
Cordoba JJ, Mullins EA, Salay LE, Eichman BF, Chazin WJ
J Mol Biol (2023) 435 pp. 168330-168330 [ Pubmed: 37884206 DOI: doi:10.1016/j.jmb.2023.168330 ]
- Dna primase large subunit (Protein from Homo sapiens)
- Ternary complex of polymerase alpha-primase bound to an rna primed-template substrate. (200 kDa, Complex from Homo sapiens)
- Dna polymerase alpha subunit b (Protein from Homo sapiens)
- Rna priming substrate - template (DNA from Homo sapiens)
- Dna polymerase alpha catalytic subunit (Protein from Homo sapiens)
- Rna priming substrate - primer (RNA from Homo sapiens)
- Dna primase small subunit (Protein from Homo sapiens)
RNA priming complex of Human Polymerase-Alpha-Primase (Conformation 1)
Cordoba JJ, Mullins EA, Salay LE, Eichman BF, Chazin WJ
J Mol Biol (2023) 435 pp. 168330-168330 [ Pubmed: 37884206 DOI: doi:10.1016/j.jmb.2023.168330 ]
- Dna primase large subunit (Protein from Homo sapiens)
- Ternary complex of polymerase alpha-primase bound to an rna primed-template substrate. (200 kDa, Complex from Homo sapiens)
- Dna polymerase alpha subunit b (Protein from Homo sapiens)
- Rna priming substrate - template (DNA from Homo sapiens)
- Dna polymerase alpha catalytic subunit (Protein from Homo sapiens)
- Rna priming substrate - primer (RNA from Homo sapiens)
- Dna primase small subunit (Protein from Homo sapiens)
RNA priming complex of Human Polymerase alpha-primase (Conformation 3)
Cordoba JJ, Mullins EA, Salay LE, Eichman BF, Chazin WJ
J Mol Biol (2023) 435 pp. 168330-168330 [ Pubmed: 37884206 DOI: doi:10.1016/j.jmb.2023.168330 ]
- Dna primase large subunit (Protein from Homo sapiens)
- Ternary complex of polymerase alpha-primase bound to an rna primed-template substrate. (200 kDa, Complex from Homo sapiens)
- Dna polymerase alpha subunit b (Protein from Homo sapiens)
- Rna priming substrate - template (DNA from Homo sapiens)
- Dna polymerase alpha catalytic subunit (Protein from Homo sapiens)
- Rna priming substrate - primer (RNA from Homo sapiens)
- Dna primase small subunit (Protein from Homo sapiens)
Drosophila Dicer-2 bound to blunt dsRNA
Resolution: 6.8 Å
EM Method: Single-particle
Fitted PDBs: 6bu9
Q-score: 0.193
Sinha NK, Iwasa J, Shen PS, Bass BL
Science (2018) 359 pp. 329-334 [ DOI: doi:10.1126/science.aaq0921 Pubmed: 29269422 ]
- Drosophila dicer-2 bound to blunt dsrna (Complex from Drosophila melanogaster)
- Rna (5'-r(*ap*cp*up*ap*cp*up*ap*up*ap*cp*ap*ap*cp*cp*up*ap*c)-3') (16 kDa, RNA from unidentified)
- Dicer-2, isoform a (198 kDa, Protein from Drosophila melanogaster)
- Rna (5'-r(*gp*gp*ap*gp*gp*up*ap*gp*up*ap*gp*gp*up*up*gp*up*ap*up*ap*gp*up*ap*gp*u)-3') (16 kDa, RNA from unidentified)
RNA-targeting by the Type III-A CRISPR-Cas Csm complex of Thermus thermophilus
Staals RHJ, Zhu Y, Taylor DW, Kornfeld JE, Sharma K, Barendregt A, Koehorst JJ, Vlot M, Neupane N, Varossieau K, Sakamoto K, Suzuki T, Dohmae N, Yokoyama S, Schaap PJ, Urlaub H, Heck AJR, Nogales E, Doudna JA, Shinkai A, van der Oost J
Mol Cell (2014) 56 pp. 518-530 [ Pubmed: 25457165 DOI: doi:10.1016/j.molcel.2014.10.005 ]
- Type iii-a crispr-cas csm complex of thermus thermophilus (426 kDa, Sample)
- Csm5 (45 kDa, Protein from Thermus thermophilus)
- Csm3 (27 kDa, Protein from Thermus thermophilus)
- Csm1 (90 kDa, Protein from Thermus thermophilus)
- Csm2 (16 kDa, Protein from Thermus thermophilus)
- Crispr rna (14 kDa, RNA from Thermus thermophilus)
- Csm4 (32 kDa, Protein from Thermus thermophilus)
CasA mediates Cas3-catalyzed target degradation during CRISPR RNA-guided interference
Hochstrasser ML, Taylor DW, Bhat P, Guegler CK, Sternberg SH, Nogales E, Doudna JA
PNAS (2014) 111 pp. 6618-6623 [ DOI: doi:10.1073/pnas.1405079111 Pubmed: 24748111 ]
- Crispr system cascade subunit casb (18 kDa, Protein from Escherichia coli K-12)
- Cascade bound to a 72 bp target dsdna (443 kDa, Sample)
- Crispr system cascade subunit casa (55 kDa, Protein from Escherichia coli K-12)
- R44 crispr rna (18 kDa, RNA from Escherichia coli K-12)
- Crispr system cascade subunit casc (40 kDa, Protein from Escherichia coli K-12)
- Crispr system cascade subunit casd (25 kDa, Protein from Escherichia coli K-12)
- Crispr system cascade subunit case (22 kDa, Protein from Escherichia coli K-12)
- 72 bp dsdna target with r44 protospacer (44 kDa, DNA from Enterobacteria phage P7)
CasA mediates Cas3-catalyzed target degradation during CRISPR RNA-guided interference
Hochstrasser ML, Taylor DW, Bhat P, Guegler CK, Sternberg SH, Nogales E, Doudna JA
PNAS (2014) 111 pp. 6618-6623 [ DOI: doi:10.1073/pnas.1405079111 Pubmed: 24748111 ]
- Crispr system cascade subunit casb (18 kDa, Protein from Escherichia coli K-12)
- Crispr system cascade subunit casa (55 kDa, Protein from Escherichia coli K-12)
- R44 crispr rna (18 kDa, RNA from Escherichia coli K-12)
- Cas3 bound to dsdna-cascade (543 kDa, Sample)
- Crispr-associated endonuclease/helicase cas3 (100 kDa, Protein from Escherichia coli K-12)
- Crispr system cascade subunit casc (40 kDa, Protein from Escherichia coli K-12)
- Crispr system cascade subunit casd (25 kDa, Protein from Escherichia coli K-12)
- Crispr system cascade subunit case (22 kDa, Protein from Escherichia coli K-12)
- 72 bp dsdna target with r44 protospacer (44 kDa, DNA from Enterobacteria phage P7)
Structures of Cas9 endonucleases reveal RNA-mediated conformational activation
Jinek M, Jiang F, Taylor DW, Sternberg SH, Kaya E, Ma E, Anders C, Hauer M, Zhou K, Lin S, Kaplan M, Iavarone AT, Charpentier E, Nogales E, Doudna JA
Science (2014) 343 pp. 1247997- [ DOI: doi:10.1126/science.1247997 Pubmed: 24505130 ]
- Crispr rna (14 kDa, RNA from Streptococcus pyogenes)
- Cas9 loaded with crrna:tracrrna (196 kDa, Sample)
- Trans-activating crispr rna (24 kDa, RNA from Streptococcus pyogenes)
- Crispr-associated endonuclease cas9 (159 kDa, Protein from Streptococcus pyogenes)
Structures of Cas9 endonucleases reveal RNA-mediated conformational activation
Jinek M, Jiang F, Taylor DW, Sternberg SH, Kaya E, Ma E, Anders C, Hauer M, Zhou K, Lin S, Kaplan M, Iavarone AT, Charpentier E, Nogales E, Doudna JA
Science (2014) 343 pp. 1247997- [ DOI: doi:10.1126/science.1247997 Pubmed: 24505130 ]
- Crispr-associated endonuclease cas9 (159 kDa, Protein from Streptococcus pyogenes)
- Crispr rna (14 kDa, RNA from Streptococcus pyogenes)
- 55 bp dna duplex non-target strand (17 kDa, DNA from Enterobacteria phage lambda)
- Cas9 loaded with crrna:tracrrna and bound to target dna duplex (230 kDa, Sample)
- 55 bp dna duplex target strand (17 kDa, DNA from Enterobacteria phage lambda)
- Trans-activating crispr rna (24 kDa, RNA from Streptococcus pyogenes)
Structure and activity of an RNA-targeting Type III-B CRISPER-Cas complex
Staals RH, Agari Y, Maki-Yonekura S, Zhu Y, Taylor DW, van Duijn E, Barendregt A, Vlot M, Koehorst JJ, Sakamoto K, Masuda A, Dohmae N, Schaap PJ, Doudna JA, Heck AJ, Yonekura K, van der Oost J, Shinkai A
Mol Cell (2013) 52 pp. 135-145 [ Pubmed: 24119403 DOI: doi:10.1016/j.molcel.2013.09.013 ]
- Type iii-b crispr-cas complex of thermus thermophilus (365 kDa, Sample)
- Crispr rna (RNA from Thermus thermophilus)
- Crispr-associated protein tm1791 (38 kDa, Protein from Thermus thermophilus)
- Crispr-associated protein tm1795 (44 kDa, Protein from Thermus thermophilus)
- Crispr-associated protein cmr3 (39 kDa, Protein from Thermus thermophilus)
- Crispr-associated ramp cmr4 (37 kDa, Protein from Thermus thermophilus)
- Crispr-associated protein crm2 (65 kDa, Protein from Thermus thermophilus)
- Crispr system cmr subunit cmr5 (12 kDa, Protein from Thermus thermophilus)