Structure of EG.5.1 S trimer with 2 down-RBDs complex with antibody CYFN1006-2.
To Be Published
- Cyfn1006-2 light chain (22 kDa, Protein from Escherichia phage T4)
- Cyfn1006-2 heavy chain (23 kDa, Protein from synthetic construct)
- Structure of eg.5.1 s trimer with 2 down-rbds complex with antibody cyfn1006-2. (Complex from Escherichia phage T4)
- Spike glycoprotein,fibritin,expression tag (143 kDa, Protein from synthetic construct)
Local CryoEM structure of the SARS-CoV-2 BA.5 in complex with ORB10 Fab
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8zpp
Q-score: 0.477
To Be Published
- Variable heavy chain of orb10 fab (13 kDa, Protein from Mus musculus)
- Spike glycoprotein,fibritin (139 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 ba.5 spike in complex with orb10 fab (Complex from Severe acute respiratory syndrome coronavirus 2)
- Variable light chain of orb10 fab (11 kDa, Protein from Mus musculus)
Structure of a SARS-CoV-2 spike S2 subunit in a pre-fusion, open conformation
Resolution: 2.93 Å
EM Method: Single-particle
Fitted PDBs: 8v5v
Q-score: 0.421
Olmedillas E, Diaz R, Hastie K, Ollmann-Saphire E
To Be Published
- Variable domain of the heavy chain from the human antibody 6c10 (13 kDa, Protein from Homo sapiens)
- Spike protein s2,fibritin (64 kDa, Protein from Tequatrovirus T4)
- Fab fragment of the 6c10 human monoclonal antibody (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Structure of a sars-cov-2 spike s2 subunit in a pre-fusion, open conformation (Complex from Mus musculus molossinus)
- Structure of a sars-cov-2 spike s2 subunit in a pre-fusion, open conformation in complex with the 6c10 fab (280 kDa, Complex from Severe acute respiratory syndrome coronavirus 2)
- Variable domain of the light chain from the human antibody 6c10 (11 kDa, Protein from Homo sapiens)
Cryo-EM structure of the Sars-Cov2 S trimer without RBDs
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8r87
Q-score: 0.496
Letscher H, Guilligay D, Sulbaran G, Amen A, Effantin G, Dereuddre-Bosquet N, Burger JA, Poniman M, Grobben M, Dergan Dylon S, Lemaitre J, Gros W, Galllouet A, Herate C, Relouzat F, Schoehn G, van der Werf S, van Gils MJ, Sanders RW, Poignard P, Le Grand R, Weissnhorn W
To Be Published
SARS-CoV-2 Spike protein Beta Variant at 4C structural flexibility / heterogeneity analyses
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 9gdx
Q-score: 0.285
Herreros D, Mata CP, Noddings C, Irene D, Krieger J, Agard DA, Tsai MD, Sorzano COS, Carazo JM
bioRxiv (2024) [ DOI: doi:10.1101/2024.09.16.613176 Pubmed: 39345408 ]
SARS-CoV-2 Spike protein Beta Variant at 37C structural flexibility / heterogeneity analyses
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 9gdy
Q-score: 0.239
Herreros D, Mata CP, Noddings C, Irene D, Krieger J, Agard DA, Tsai MD, Sorzano COS, Carazo JM
bioRxiv (2024) [ DOI: doi:10.1101/2024.09.16.613176 Pubmed: 39345408 ]
SARS-CoV-2 BA-2.87.1 Spike ectodomain
Duyvesteyn HME, Dijokaite-Guraliuc A, Liu C, Supasa P, Kronsteiner B, Jeffery K, Stafford L, Klenerman P, Dunachie SJ, Mongkolsapaya J, Fry EE, Ren J, Stuart DI, Screaton GR
Structure (2024) 32 pp. 1594- [ DOI: doi:10.1016/j.str.2024.07.020 Pubmed: 39173622 ]
Omicron BA.1 Spike protein with neutralizing NTD specific mAb K501SP6
Bjoernsson KH, Walker MR, Raghavan SSR, Ward AB, Barfod LK
To Be Published
- Spike glycoprotein,fibritin (141 kDa, Protein from Enterobacteria phage T4)
- Spike glycoprotein with fibritin (Complex from Severe acute respiratory syndrome coronavirus 2)
- Alphacoronavirus (Complex)
- K501sp6 fv heavy chain (14 kDa, Protein from Homo sapiens)
- K501sp6 fv light chain (14 kDa, Protein from Homo sapiens)
- Antibody (Complex from Homo sapiens)
Stabilised BA.1 SARS-CoV-2 spike with H6 nanobodies in '3 up' RBD conformation
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 8oyt
Q-score: 0.161
Cornish K, Huo J, Jones L, Sharma P, Thrush JW, Abdelkarim S, Kipar A, Ramadurai S, Weckener M, Mikolajek H, Liu S, Buckle I, Bentley E, Kirby A, Han X, Laidlaw SM, Hill M, Eyssen L, Norman C, Le Bas A, Clarke J, James W, Stewart JP, Carroll M, Naismith JH, Owens RJ
Open Biol (2024) 14 pp. 230252-230252 [ DOI: doi:10.1098/rsob.230252 Pubmed: 38835241 ]
- H6 nanobody (14 kDa, Protein from Lama glama)
- Stabilised hexapro omicron ba.1 spike trimer (Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein,fibritin (140 kDa, Protein from Tequatrovirus T4)
- Complex of stabilised hexapro omicron ba.1 spike trimer with three h6 nanobodies (Complex)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- H6 nanobody (Complex from Lama glama)
SARS-CoV2 Omicron BA.1 RBD in complex with CAB-A17 antibody
Resolution: 2.68 Å
EM Method: Single-particle
Fitted PDBs: 8c0y
Q-score: 0.491
Sheward DJ, Pushparaj P, Das H, Greaney AJ, Kim C, Kim S, Hanke L, Hyllner E, Dyrdak R, Lee J, Dopico XC, Dosenovic P, Peacock TP, McInerney GM, Albert J, Corcoran M, Bloom JD, Murrell B, Karlsson Hedestam GB, Hallberg BM
Cell Rep Med (2024) 5 pp. 101577-101577 [ DOI: doi:10.1016/j.xcrm.2024.101577 Pubmed: 38761799 ]
- Cab-a17 antibody (fab) (Complex from Enterobacteria phage T4)
- Sars-cov-2 omicron rbd (Complex from Severe acute respiratory syndrome coronavirus 2)
- Cab-a17 antibody (variable) (11 kDa, Protein from Homo sapiens)
- Cab-a17 antibody (variable) (12 kDa, Protein from Homo sapiens)
- Spike protein s2' (21 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov2 omicron ba.1 spike in complex with cab-a17 antibody (95 kDa, Complex)