Structure of a SARS-CoV-2 spike S2 subunit in a pre-fusion, open conformation
Resolution: 2.93 Å
EM Method: Single-particle
Fitted PDBs: 8v5v
Q-score: 0.421
Olmedillas E, Diaz R, Hastie K, Ollmann-Saphire E
To Be Published
- Structure of a sars-cov-2 spike s2 subunit in a pre-fusion, open conformation (Complex from Mus musculus molossinus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Variable domain of the light chain from the human antibody 6c10 (11 kDa, Protein from Homo sapiens)
- Spike protein s2,fibritin (64 kDa, Protein from Tequatrovirus T4)
- Variable domain of the heavy chain from the human antibody 6c10 (13 kDa, Protein from Homo sapiens)
- Structure of a sars-cov-2 spike s2 subunit in a pre-fusion, open conformation in complex with the 6c10 fab (280 kDa, Complex from Severe acute respiratory syndrome coronavirus 2)
- Fab fragment of the 6c10 human monoclonal antibody (Complex from Homo sapiens)
SARS-CoV2 Omicron BA.1 RBD in complex with CAB-A17 antibody
Resolution: 2.68 Å
EM Method: Single-particle
Fitted PDBs: 8c0y
Q-score: 0.491
Sheward DJ, Pushparaj P, Das H, Greaney AJ, Kim C, Kim S, Hanke L, Hyllner E, Dyrdak R, Lee J, Dopico XC, Dosenovic P, Peacock TP, McInerney GM, Albert J, Corcoran M, Bloom JD, Murrell B, Karlsson Hedestam GB, Hallberg BM
Cell Rep Med (2024) 5 pp. 101577-101577 [ DOI: doi:10.1016/j.xcrm.2024.101577 Pubmed: 38761799 ]
- Sars-cov-2 omicron rbd (Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike protein s2' (21 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Cab-a17 antibody (variable) (12 kDa, Protein from Homo sapiens)
- Cab-a17 antibody (fab) (Complex from Enterobacteria phage T4)
- Sars-cov2 omicron ba.1 spike in complex with cab-a17 antibody (95 kDa, Complex)
- Cab-a17 antibody (variable) (11 kDa, Protein from Homo sapiens)
SARS-CoV2 Omicron BA.1 spike in complex with CAB-A17 antibody
Resolution: 2.56 Å
EM Method: Single-particle
Fitted PDBs: 8c2r
Q-score: 0.436
Sheward DJ, Pushparaj P, Das H, Greaney AJ, Kim C, Kim S, Hanke L, Hyllner E, Dyrdak R, Lee J, Dopico XC, Dosenovic P, Peacock TP, McInerney GM, Albert J, Corcoran M, Bloom JD, Murrell B, Karlsson Hedestam GB, Hallberg BM
Cell Rep Med (2024) 5 pp. 101577-101577 [ DOI: doi:10.1016/j.xcrm.2024.101577 Pubmed: 38761799 ]
- Cab-a17 antibody (lc) (23 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cab-a17 antibody (fab) (Complex from Enterobacteria phage T4)
- Sars-cov2 omicron ba.1 spike (Complex from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov2 omicron ba.1 spike in complex with cab-a17 antibody (95 kDa, Complex)
- Spike glycoprotein (124 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Cab-a17 antibody (hc) (22 kDa, Protein from Homo sapiens)
BA.4/5 SARS-CoV-2 Spike bound to human ACE2 (local)
Resolution: 2.92 Å
EM Method: Single-particle
Fitted PDBs: 8aqs
Q-score: 0.549
Ni D, Turelli P, Beckert B, Nazarov S, Uchikawa E, Myasnikov A, Pojer F, Trono D, Stahlberg H, Lau K
PLoS Pathog (2023) 19 pp. e1011206-e1011206 [ Pubmed: 37018380 DOI: doi:10.1371/journal.ppat.1011206 ]
- Zinc ion (65 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Ba.4/5 sars-cov-2 spike bound to human ace2 (local) (430 kDa, Complex)
- Processed angiotensin-converting enzyme 2 (101 kDa, Protein from Homo sapiens)
- Sars-cov-2 ba.4/5 spike protein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Human ace2 (Complex from Homo sapiens)
- Water (18 Da, Ligand)
- Spike glycoprotein,fibritin (142 kDa, Protein from Enterobacteria phage T4)
Beta SARS-CoV-2 Spike bound to mouse ACE2 (local)
Resolution: 4.4 Å
EM Method: Single-particle
Fitted PDBs: 8aqt
Q-score: 0.212
Ni D, Turelli P, Beckert B, Nazarov S, Uchikawa E, Myasnikov A, Pojer F, Trono D, Stahlberg H, Lau K
PLoS Pathog (2023) 19 pp. e1011206-e1011206 [ Pubmed: 37018380 DOI: doi:10.1371/journal.ppat.1011206 ]
- Beta sars-cov-2 spike (Complex from Severe acute respiratory syndrome coronavirus 2)
- Processed angiotensin-converting enzyme 2,ig gamma-2a chain c region, membrane-bound form (101 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Mouse ace2 (Complex from Homo sapiens)
- Beta sars-cov-2 spike bound to mouse ace2 (430 kDa, Complex)
- Spike glycoprotein,fibritin (142 kDa, Protein from Enterobacteria phage T4)
SARS-CoV-2 Spike protein in complex with the single chain fragment scFv76
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7zce
Q-score: 0.354
Milazzo FM, Chaves-Sanjuan A, Minenkova O, Santapaola D, Anastasi AM, Battistuzzi G, Chiapparino C, Rosi A, Merlo Pich E, Albertoni C, Marra E, Luberto L, Viollet C, Spagnoli LG, Riccio A, Rossi A, Santoro MG, Ballabio F, Paissoni C, Camilloni C, Bolognesi M, De Santis R
Mol Ther (2022) 31 pp. 362-373 [ DOI: doi:10.1016/j.ymthe.2022.09.010 Pubmed: 36114671 ]
- Spike glycoprotein,fibritin (142 kDa, Protein from Enterobacteria phage T4)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Scfv76 single chain fragment (28 kDa, Protein from Homo sapiens)
- Sars-cov-2 spike protein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 spike protein in complex with the single chain fragment scfv76 (510 kDa, Complex)
- Scfv76 single chain fragment (Complex from Homo sapiens)
SARS-CoV-2 Spike RBD in complex with the single chain fragment scFv76 (Focused Refinement)
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 7zcf
Q-score: 0.387
Milazzo FM, Chaves-Sanjuan A, Minenkova O, Santapaola D, Anastasi AM, Battistuzzi G, Chiapparino C, Rosi A, Merlo Pich E, Albertoni C, Marra E, Luberto L, Viollet C, Spagnoli LG, Riccio A, Rossi A, Santoro MG, Ballabio F, Paissoni C, Camilloni C, Bolognesi M, De Santis R
Mol Ther (2022) 31 pp. 362-373 [ DOI: doi:10.1016/j.ymthe.2022.09.010 Pubmed: 36114671 ]
- Spike glycoprotein,fibritin (142 kDa, Protein from Enterobacteria phage T4)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Scfv76 single chain fragment (28 kDa, Protein from Homo sapiens)
- Sars-cov-2 spike protein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 spike protein in complex with the single chain fragment scfv76 (510 kDa, Complex)
- Scfv76 single chain fragment (Complex from Homo sapiens)
OMI-42 FAB IN COMPLEX WITH SARS-COV-2 BETA SPIKE GLYCOPROTEIN
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 7zr7
Q-score: 0.258
Nutalai R, Zhou D, Tuekprakhon A, Ginn HM, Supasa P, Liu C, Huo J, Mentzer AJ, Duyvesteyn HME, Dijokaite-Guraliuc A, Skelly D, Ritter TG, Amini A, Bibi S, Adele S, Johnson SA, Constantinides B, Webster H, Temperton N, Klenerman P, Barnes E, Dunachie SJ, Crook D, Pollard AJ, Lambe T, Goulder P, Paterson NG, Williams MA, Hall DR, Mongkolsapaya J, Fry EE, Dejnirattisai W, Ren J, Stuart DI, Screaton GR
Cell (2022) 185 pp. 2116-2131.e18 [ DOI: doi:10.1016/j.cell.2022.05.014 Pubmed: 35662412 ]
- Omi-42 fab (Complex from Homo sapiens)
- Sars-cov-2 beta spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Omi-42 fab in complex with sars-cov-2 beta spike glycoprotein (Complex)
- Omi-42 light chain (11 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Omi-42 heavy chain (13 kDa, Protein from Homo sapiens)
- Spike glycoprotein,fibritin (141 kDa, Protein from Tequatrovirus T4)
OMI-38 FAB IN COMPLEX WITH SARS-COV-2 BETA SPIKE RBD (local refinement)
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 7zr8
Q-score: 0.47
Nutalai R, Zhou D, Tuekprakhon A, Ginn HM, Supasa P, Liu C, Huo J, Mentzer AJ, Duyvesteyn HME, Dijokaite-Guraliuc A, Skelly D, Ritter TG, Amini A, Bibi S, Adele S, Johnson SA, Constantinides B, Webster H, Temperton N, Klenerman P, Barnes E, Dunachie SJ, Crook D, Pollard AJ, Lambe T, Goulder P, Paterson NG, Williams MA, Hall DR, Mongkolsapaya J, Fry EE, Dejnirattisai W, Ren J, Stuart DI, Screaton GR
Cell (2022) 185 pp. 2116-2131.e18 [ DOI: doi:10.1016/j.cell.2022.05.014 Pubmed: 35662412 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sars-cov-2 beta spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Omi-38 fab in complex with sars-cov-2 beta spike glycoprotein (Complex)
- Omi-38 fab heavy chain (12 kDa, Protein from Homo sapiens)
- Omi-38 fab (Complex from Homo sapiens)
- Spike glycoprotein,fibritin (141 kDa, Protein from Enterobacteria phage T4)
- Omi-38 fab light chain (11 kDa, Protein from Homo sapiens)
OMI-2 FAB IN COMPLEX WITH SARS-COV-2 BETA SPIKE GLYCOPROTEIN
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 7zr9
Q-score: 0.259
Nutalai R, Zhou D, Tuekprakhon A, Ginn HM, Supasa P, Liu C, Huo J, Mentzer AJ, Duyvesteyn HME, Dijokaite-Guraliuc A, Skelly D, Ritter TG, Amini A, Bibi S, Adele S, Johnson SA, Constantinides B, Webster H, Temperton N, Klenerman P, Barnes E, Dunachie SJ, Crook D, Pollard AJ, Lambe T, Goulder P, Paterson NG, Williams MA, Hall DR, Mongkolsapaya J, Fry EE, Dejnirattisai W, Ren J, Stuart DI, Screaton GR
Cell (2022) 185 pp. 2116-2131.e18 [ DOI: doi:10.1016/j.cell.2022.05.014 Pubmed: 35662412 ]
- Omi-2 fab in complex with sars-cov-2 beta spike glycoprotein (Complex)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sars-cov-2 beta spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Omi-2 fab (Complex from Homo sapiens)
- Omi-2 fab light chain (11 kDa, Protein from Homo sapiens)
- Omi-2 fab heavy chain (14 kDa, Protein from Homo sapiens)
- Spike glycoprotein,fibritin (141 kDa, Protein from Enterobacteria phage T4)