MERS NTD-specific polyclonal antibodies
Abiona OM, Wang N, Leist SR, Schafer A, Cockrell AS, Wang L, Bangaru S, Stevens L, Graham RL, Kocher JF, Tsybovsky Y, Kanekiyo M, Kumar A, Morabito KM, Rosen O, Shi W, Werner A, Zhang Y, Ziwawo C, Dzuvor CKO, Palandjian C, Eastman C, Matthews HR, Joseph J, Chappell JD, Kong WP, Mascola JR, Ward AB, Denison MR, Baric R, McLellan JS, Graham BS, Corbett-Helaire KS
iScience (2025) 28 pp. 111632-111632 [ Pubmed: 39898019 DOI: doi:10.1016/j.isci.2024.111632 ]
BtCoV-422 in complex with neutralizing antibody JC57-11
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8sak
Q-score: 0.514
Tse LV, Hou YJ, McFadden E, Lee RE, Scobey TD, Leist SR, Martinez DR, Meganck RM, Schafer A, Yount BL, Mascenik T, Powers JM, Randell SH, Zhang Y, Wang L, Mascola J, McLellan JS, Baric RS
Sci Transl Med (2023) 15 pp. eadg5567-eadg5567 [ Pubmed: 37756379 DOI: doi:10.1126/scitranslmed.adg5567 ]
- Spike glycoprotein (142 kDa, Protein from unclassified Merbecovirus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Btcov-422 spike (600 kDa, Complex from Middle East respiratory syndrome-related coronavirus)
- Jc57-11 fab light chain (23 kDa, Protein from Macaca)
- Jc57-11 fab heavy chain (25 kDa, Protein from Macaca)
- Jc57-11 fab (50 kDa, Complex from Macaca)
- Btcov-422 in complex with jc57-11 fab (650 kDa, Complex)
BtCoV-422 spike in complex with JC57-11 Fab, global map
Tse LV, Hou YJ, McFadden E, Lee RE, Scobey TD, Leist SR, Martinez DR, Meganck RM, Schafer A, Yount BL, Mascenik T, Powers JM, Randell SH, Zhang Y, Wang L, Mascola J, McLellan JS, Baric RS
Sci Transl Med (2023) 15 pp. eadg5567-eadg5567 [ Pubmed: 37756379 DOI: doi:10.1126/scitranslmed.adg5567 ]
- Btcov-422 spike in complex with jc57-11 fab (650 kDa, Complex)
- Jc57-11 fab (50 kDa, Complex from Macaca)
- Btcov-422 spike (600 kDa, Complex from Middle East respiratory syndrome-related coronavirus)
BtCoV-422 spike in complex with JC57-11 Fab, local map
Tse LV, Hou YJ, McFadden E, Lee RE, Scobey TD, Leist SR, Martinez DR, Meganck RM, Schafer A, Yount BL, Mascenik T, Powers JM, Randell SH, Zhang Y, Wang L, Mascola J, McLellan JS, Baric RS
Sci Transl Med (2023) 15 pp. eadg5567-eadg5567 [ Pubmed: 37756379 DOI: doi:10.1126/scitranslmed.adg5567 ]
- Btcov-422 spike (600 kDa, Complex from Middle East respiratory syndrome-related coronavirus)
- Jc57-11 fab (50 kDa, Complex from Macaca)
- Btcov-422 in complex with jc57-11 fab (650 kDa, Complex)
Negative stain EM map of MERS 2 in complex with G2 Fab
Wang N, Rosen O, Wang L, Turner HL, Stevens LJ, Corbett KS, Bowman CA, Pallesen J, Shi W, Zhang Y, Leung K, Kirchdoerfer RN, Becker MM, Denison MR, Chappell JD, Ward AB, Graham BS, McLellan JS
Cell Rep (2019) 28 pp. 3395-3405.e6 [ DOI: doi:10.1016/j.celrep.2019.08.052 Pubmed: 31553909 ]
MERS S0 trimer in complex with antibody G2
Resolution: 4.19 Å
EM Method: Single-particle
Fitted PDBs: 6pz8
Q-score: 0.133
Wang N, Rosen O, Wang L, Turner HL, Stevens LJ, Corbett KS, Bowman CA, Pallesen J, Shi W, Zhang Y, Leung K, Kirchdoerfer RN, Becker MM, Denison MR, Chappell JD, Ward AB, Graham BS, McLellan JS
Cell Rep (2019) 28 pp. 3395-3405.e6 [ DOI: doi:10.1016/j.celrep.2019.08.052 Pubmed: 31553909 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- G2 light chain (23 kDa, Protein from Mus musculus)
- Antibody g2 (Complex from Mus musculus)
- S protein (51 kDa, Protein from Middle East respiratory syndrome-related coronavirus)
- Mers s0 ectodomain trimer in complex with antibody g2 (Complex)
- G2 heavy chain (24 kDa, Protein from Mus musculus)
- Mers s0 ectodomain trimer (Complex from Middle East respiratory syndrome-related coronavirus)
- S protein (80 kDa, Protein from Middle East respiratory syndrome-related coronavirus)
MERS S ectodomain trimer in complex with Fab of neutralizing antibody G4
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 5w9h
Q-score: 0.313
Pallesen J, Wang N, Corbett KS, Wrapp D, Kirchdoerfer RN, Turner HL, Cottrell CA, Becker MM, Wang L, Shi W, Kong WP, Andres EL, Kettenbach AN, Denison MR, Chappell JD, Graham BS, Ward AB, McLellan JS
PNAS (2017) 114 pp. E7348-E7357 [ Pubmed: 28807998 DOI: doi:10.1073/pnas.1707304114 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- G4 vh (25 kDa, Protein from Mus musculus)
- Mers s (146 kDa, Protein from Middle East respiratory syndrome-related coronavirus)
- G4 vl (23 kDa, Protein from Mus musculus)
- Mers s ectodomain trimer in complex with fab of neutralizing antibody g4 (600 kDa, Complex from Middle East respiratory syndrome-related coronavirus)
MERS S ectodomain trimer in complex with Fab of neutralizing antibody G4
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 5w9i
Q-score: 0.414
Pallesen J, Wang N, Corbett KS, Wrapp D, Kirchdoerfer RN, Turner HL, Cottrell CA, Becker MM, Wang L, Shi W, Kong WP, Andres EL, Kettenbach AN, Denison MR, Chappell JD, Graham BS, Ward AB, McLellan JS
PNAS (2017) 114 pp. E7348-E7357 [ Pubmed: 28807998 DOI: doi:10.1073/pnas.1707304114 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- G4 vh (25 kDa, Protein from Mus musculus)
- Spike glycoprotein (146 kDa, Protein from Middle East respiratory syndrome-related coronavirus)
- G4 vl (23 kDa, Protein from Mus musculus)
- Mers s ectodomain trimer in complex with fab of neutralizing antibody g4 (600 kDa, Complex from Middle East respiratory syndrome-related coronavirus)
MERS S ectodomain trimer in complex with Fab of neutralizing antibody G4
Resolution: 4.8 Å
EM Method: Single-particle
Fitted PDBs: 5w9j
Q-score: 0.237
Pallesen J, Wang N, Corbett KS, Wrapp D, Kirchdoerfer RN, Turner HL, Cottrell CA, Becker MM, Wang L, Shi W, Kong WP, Andres EL, Kettenbach AN, Denison MR, Chappell JD, Graham BS, Ward AB, McLellan JS
PNAS (2017) 114 pp. E7348-E7357 [ Pubmed: 28807998 DOI: doi:10.1073/pnas.1707304114 ]
- Mers s ectodomain trimer in complex with fab of neutralizing antibody g4 (600 kDa, Complex from Middle East respiratory syndrome-related coronavirus)
- G4 vl (23 kDa, Protein from Mus musculus)
- Spike glycoprotein (146 kDa, Protein from Middle East respiratory syndrome-related coronavirus)
- G4 vh (25 kDa, Protein from Mus musculus)
MERS S ectodomain trimer in complex with Fab of neutralizing antibody G4
Resolution: 4.6 Å
EM Method: Single-particle
Fitted PDBs: 5w9k
Q-score: 0.242
Pallesen J, Wang N, Corbett KS, Wrapp D, Kirchdoerfer RN, Turner HL, Cottrell CA, Becker MM, Wang L, Shi W, Kong WP, Andres EL, Kettenbach AN, Denison MR, Chappell JD, Graham BS, Ward AB, McLellan JS
PNAS (2017) 114 pp. E7348-E7357 [ Pubmed: 28807998 DOI: doi:10.1073/pnas.1707304114 ]
- Mers s ectodomain trimer in complex with fab of neutralizing antibody g4 (600 kDa, Complex from Middle East respiratory syndrome-related coronavirus)
- G4 vl (23 kDa, Protein from Mus musculus)
- Spike glycoprotein (146 kDa, Protein from Middle East respiratory syndrome-related coronavirus)
- G4 vh (25 kDa, Protein from Mus musculus)