Structural basis for broad coronavirus neutralization
Sauer MM, Tortorici MA, Park YJ, Walls AC, Homad L, Acton OJ, Bowen JE, Wang C, Xiong X, de van der Schueren W, Quispe J, Hoffstrom BG, Bosch BJ, McGuire AT, Veesler D
Nat Struct Mol Biol (2021) 28 pp. 478-486 [ DOI: doi:10.1038/s41594-021-00596-4 Pubmed: 33981021 ]
MERS-CoV S bound to the broadly neutralizing B6 Fab fragment (C3 refinement)
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 7m5e
Q-score: 0.605
Sauer MM, Tortorici MA, Park YJ, Walls AC, Homad L, Acton OJ, Bowen JE, Wang C, Xiong X, de van der Schueren W, Quispe J, Hoffstrom BG, Bosch BJ, McGuire AT, Veesler D
Nat Struct Mol Biol (2021) 28 pp. 478-486 [ DOI: doi:10.1038/s41594-021-00596-4 Pubmed: 33981021 ]
- Mers-cov s ectodomain trimer bound to the b6 fab fragment in the presence of 100 mm neuraminic acid (Complex)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Spike glycoprotein (149 kDa, Protein from Middle East respiratory syndrome-related coronavirus)
- Mers-cov s ectodomain trimer (Complex from Middle East respiratory syndrome-related coronavirus)
- B6 fab fragment (Complex from Mus musculus)
- Folic acid (441 Da, Ligand)
- N-acetyl-alpha-neuraminic acid (309 Da, Ligand)
MERS-CoV complex with human neutralizing LCA60 antibody Fab fragment (state 1)
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 6nb3
Q-score: 0.402
Walls AC, Xiong X, Park YJ, Tortorici MA, Snijder J, Quispe J, Cameroni E, Gopal R, Dai M, Lanzavecchia A, Zambon M, Rey FA, Corti D, Veesler D
Cell (2019) 176 pp. 1026-1039.e15 [ DOI: doi:10.1016/j.cell.2018.12.028 Pubmed: 30712865 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Spike glycoprotein (149 kDa, Protein from Middle East respiratory syndrome-related coronavirus)
- Lca60 light chain (11 kDa, Protein from Homo sapiens)
- Lca60 heavy chain (13 kDa, Protein from Homo sapiens)
- Mers-cov complex with human neutralizing lca60 antibody fab fragment (state 1) (572 MDa, Complex from Middle East respiratory syndrome coronavirus)
MERS-CoV S complex with human neutralizing LCA60 antibody Fab fragment (state 2)
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 6nb4
Q-score: 0.403
Walls AC, Xiong X, Park YJ, Tortorici MA, Snijder J, Quispe J, Cameroni E, Gopal R, Dai M, Lanzavecchia A, Zambon M, Rey FA, Corti D, Veesler D
Cell (2019) 176 pp. 1026-1039.e15 [ DOI: doi:10.1016/j.cell.2018.12.028 Pubmed: 30712865 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Mers-cov complex with human neutralizing lca60 antibody fab fragment (state 2) (570 kDa, Complex from Middle East respiratory syndrome coronavirus)
- Lca60 light chain (11 kDa, Protein from Homo sapiens)
- Lca60 heavy chain (13 kDa, Protein from Homo sapiens)
- Spike glycoprotein (149 kDa, Protein from Middle East respiratory syndrome coronavirus)