Cryo-EM structure of Chikungunya virus in complex with Fab fragments of mAb CHK-124
Resolution: 5.2 Å
EM Method: Single-particle
Fitted PDBs: 7cvy
Q-score: 0.178
Zhou QF, Fox JM, Earnest JT, Ng TS, Kim AS, Fibriansah G, Kostyuchenko VA, Shi J, Shu B, Diamond MS, Lok SM
PNAS (2020) 117 pp. 27637-27645 [ DOI: doi:10.1073/pnas.2008051117 Pubmed: 33087569 ]
- Fab light chain (23 kDa, Protein from Mus musculus)
- Fab heavy chain (23 kDa, Protein from Mus musculus)
- E2 glycoprotein (46 kDa, Protein from Chikungunya virus)
- Fab region of chk-124 (Cellular component from Mus musculus)
- Chikungunya virus in complex with fab fragments of mab chk-124 (Complex)
- Capsid protein (16 kDa, Protein from Chikungunya virus)
- Chikungunya virus (Cellular component from Chikungunya virus)
- E1 glycoprotein (47 kDa, Protein from Chikungunya virus)
Cryo-EM structure of Chikungunya virus in complex with Fab fragments of mAb CHK-263
Resolution: 4.7 Å
EM Method: Single-particle
Fitted PDBs: 7cvz
Q-score: 0.281
Zhou QF, Fox JM, Earnest JT, Ng TS, Kim AS, Fibriansah G, Kostyuchenko VA, Shi J, Shu B, Diamond MS, Lok SM
PNAS (2020) 117 pp. 27637-27645 [ DOI: doi:10.1073/pnas.2008051117 Pubmed: 33087569 ]
- Fab light chain (23 kDa, Protein from Mus musculus)
- Chk-263 fab (Cellular component from Mus musculus)
- Fab heavy chain (22 kDa, Protein from Mus musculus)
- Capsid protein (16 kDa, Protein from Chikungunya virus)
- E2 glycoprotein (46 kDa, Protein from Chikungunya virus)
- Chikungunya virus in complex with fab fragments of mab chk-263 (Complex)
- Chikungunya virus (Cellular component from Chikungunya virus)
- E1 glycoprotein (47 kDa, Protein from Chikungunya virus)
Cryo-EM structure of Chikungunya virus in complex with mAb CHK-263 IgG
Resolution: 5.9 Å
EM Method: Single-particle
Fitted PDBs: 7cw0
Q-score: 0.184
Zhou QF, Fox JM, Earnest JT, Ng TS, Kim AS, Fibriansah G, Kostyuchenko VA, Shi J, Shu B, Diamond MS, Lok SM
PNAS (2020) 117 pp. 27637-27645 [ DOI: doi:10.1073/pnas.2008051117 Pubmed: 33087569 ]
- Fab light chain (23 kDa, Protein from Mus musculus)
- Fab heavy chain (22 kDa, Protein from Mus musculus)
- Capsid protein (16 kDa, Protein from Chikungunya virus)
- Chikungunya virus in complex with mab chk-263 igg (Complex)
- Fab region of chk-263 (Cellular component from Mus musculus)
- Chikungunya virus (Cellular component from Chikungunya virus)
- E2 glycoprotein (46 kDa, Protein from Chikungunya virus)
- E1 glycoprotein (47 kDa, Protein from Chikungunya virus)
Resolution: 4.5 Å
EM Method: Single-particle
Fitted PDBs: 7cw2
Q-score: 0.316
Zhou QF, Fox JM, Earnest JT, Ng TS, Kim AS, Fibriansah G, Kostyuchenko VA, Shi J, Shu B, Diamond MS, Lok SM
PNAS (2020) 117 pp. 27637-27645 [ DOI: doi:10.1073/pnas.2008051117 Pubmed: 33087569 ]
- Chikungunya virus (Cellular component from Chikungunya virus)
- Fab light chain (23 kDa, Protein from Mus musculus)
- Fab heavy chain (22 kDa, Protein from Mus musculus)
- Capsid protein (16 kDa, Protein from Chikungunya virus)
- Fab region of chk-263 (Cellular component from Mus musculus)
- Localized reconstruction of subregions around the icosahedral 5-fold vertex of chikv:chk-263 fab complex (Complex)
- E2 glycoprotein (46 kDa, Protein from Chikungunya virus)
- E1 glycoprotein (47 kDa, Protein from Chikungunya virus)
Resolution: 9.4 Å
EM Method: Single-particle
Fitted PDBs: 7cw3
Q-score: 0.117
Zhou QF, Fox JM, Earnest JT, Ng TS, Kim AS, Fibriansah G, Kostyuchenko VA, Shi J, Shu B, Diamond MS, Lok SM
PNAS (2020) 117 pp. 27637-27645 [ DOI: doi:10.1073/pnas.2008051117 Pubmed: 33087569 ]
- Fab region of chk-263 igg (Complex)
- Chikungunya virus (Complex from Mus musculus)
- Fab light chain (23 kDa, Protein from Mus musculus)
- Fab heavy chain (22 kDa, Protein from Mus musculus)
- Capsid protein (16 kDa, Protein from Chikungunya virus)
- Subregions around the icosahedral 2-fold vertex of chikungunya virus in complexed with chk-263 igg (Complex from Chikungunya virus)
- E2 glycoprotein (46 kDa, Protein from Chikungunya virus)
- E1 glycoprotein (47 kDa, Protein from Chikungunya virus)
Electron Cryo-Microscopy of Chikungunya in Complex with Mouse Mxra8 Receptor
Resolution: 4.99 Å
EM Method: Single-particle
Fitted PDBs: 6nk7
Q-score: 0.205
Basore K, Kim AS, Nelson CA, Zhang R, Smith BK, Uranga C, Vang L, Cheng M, Gross ML, Smith J, Diamond MS, Fremont DH
Cell (2019) 177 pp. 1725- [ Pubmed: 31080061 DOI: doi:10.1016/j.cell.2019.04.006 ]
- Chikungunya virus with mxra8 receptor (Complex)
- Mouse mxra8 receptor ectodomain (Complex from Mus musculus)
- Matrix remodeling-associated protein 8 (30 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- E2 glycoprotein (47 kDa, Protein from Chikungunya virus)
- E3 glycoprotein (6 kDa, Protein from Chikungunya virus)
- E1 glycoprotein (47 kDa, Protein from Chikungunya virus)
- Capsid protein (16 kDa, Protein from Chikungunya virus)
- Chikungunya virus (Complex from Chikungunya virus)
Cryo-EM of CHIKV VLP in complex with Fab fragment of neutralizing antibody IM-CKV063
Electron cryo-microscopy of chikungunya virus in complex with neutralizing antibody Fab CHK265
Resolution: 16.9 Å
EM Method: Single-particle
Fitted PDBs: 5any
Q-score: -0.013
Fox JM, Long F, Edeling MA, Lin H, Duijl-Richter M, Fong RH, Kahle KM, Smit JM, Jin J, Simmons G, Doranz BJ, Crowe JE, Fremont DH, Rossmann MG, Diamond MS
Cell (2015) 163 pp. 1095-1107 [ DOI: doi:10.1016/J.CELL.2015.10.050 Pubmed: 26553503 ]
Porta J, Prasad VM, Wang CI, Akahata W, Ng LF, Rossmann MG
J Virol (2016) 90 pp. 1169-1177 [ DOI: doi:10.1128/JVI.02364-15 Pubmed: 26537684 ]
Electron Cryo-microscopy of Chikungunya VLP in complex with neutralizing antibody Fab 9.8B
Resolution: 14.9 Å
EM Method: Single-particle
Fitted PDBs: 3j2y
Q-score: 0.046
Sun S, Xiang Y, Akahata W, Holdaway H, Pal P, Zhang X, Diamond MS, Nabel GJ, Rossmann MG
eLife (2013) 2 pp. e00435-e00435 [ Pubmed: 23577234 DOI: doi:10.7554/eLife.00435 ]