Structure of TAX-4_R421W w/cGMP open state
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7n15
Q-score: 0.571
Zheng X, Li H, Hu Z, Su D, Yang J
Commun Biol (2022) 5 pp. 190-190 [ Pubmed: 35233102 DOI: doi:10.1038/s42003-022-03120-6 ]
- 1,2-dilauroyl-sn-glycero-3-phosphate (535 Da, Ligand)
- Cyclic nucleotide-gated cation channel (84 kDa, Protein from Caenorhabditis elegans)
- Cyclic nucleotide-gated channel tax-4 with an achromatopsia-associated missense mutation r421w (Complex from Caenorhabditis elegans)
- 1-palmitoyl-2-linoleoyl-sn-glycero-3-phosphocholine (758 Da, Ligand)
- Cyclic guanosine monophosphate (345 Da, Ligand)
Structure of TAX-4_R421W apo closed state
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7n16
Q-score: 0.49
Structure of TAX-4_R421W apo open state
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7n17
Q-score: 0.514
Structure of cGMP-unbound WT TAX-4 reconstituted in lipid nanodiscs
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 6wej
Q-score: 0.582
Zheng X, Fu Z, Su D, Zhang Y, Li M, Pan Y, Li H, Li S, Grassucci RA, Ren Z, Hu Z, Li X, Zhou M, Li G, Frank J, Yang J
Nat Struct Mol Biol (2020) 27 pp. 625-634 [ DOI: doi:10.1038/s41594-020-0433-5 Pubmed: 32483338 ]
- 1,2-dilauroyl-sn-glycero-3-phosphate (535 Da, Ligand)
- Sodium ion (22 Da, Ligand)
- 1-palmitoyl-2-linoleoyl-sn-glycero-3-phosphocholine (758 Da, Ligand)
- Structure of cgmp-unbound wt tax-4 reconstituted in lipid nanodiscs (Complex from Caenorhabditis elegans)
- Cyclic nucleotide-gated cation channel (83 kDa, Protein from Caenorhabditis elegans)
Structure of cGMP-bound WT TAX-4 reconstituted in lipid nanodiscs
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 6wek
Q-score: 0.593
Zheng X, Fu Z, Su D, Zhang Y, Li M, Pan Y, Li H, Li S, Grassucci RA, Ren Z, Hu Z, Li X, Zhou M, Li G, Frank J, Yang J
Nat Struct Mol Biol (2020) 27 pp. 625-634 [ DOI: doi:10.1038/s41594-020-0433-5 Pubmed: 32483338 ]
- 1,2-dilauroyl-sn-glycero-3-phosphate (535 Da, Ligand)
- 1-palmitoyl-2-linoleoyl-sn-glycero-3-phosphocholine (758 Da, Ligand)
- Cyclic guanosine monophosphate (345 Da, Ligand)
- Cyclic nucleotide-gated cation channel (83 kDa, Protein from Caenorhabditis elegans)
- Structure of cgmp-bound wt tax-4 reconstituted in lipid nanodiscs (Complex from Caenorhabditis elegans)
Structure of cGMP-unbound F403V/V407A mutant TAX-4 reconstituted in lipid nanodiscs
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 6wel
Q-score: 0.616
Zheng X, Fu Z, Su D, Zhang Y, Li M, Pan Y, Li H, Li S, Grassucci RA, Ren Z, Hu Z, Li X, Zhou M, Li G, Frank J, Yang J
Nat Struct Mol Biol (2020) 27 pp. 625-634 [ DOI: doi:10.1038/s41594-020-0433-5 Pubmed: 32483338 ]
- 1,2-dilauroyl-sn-glycero-3-phosphate (535 Da, Ligand)
- Sodium ion (22 Da, Ligand)
- 1-palmitoyl-2-linoleoyl-sn-glycero-3-phosphocholine (758 Da, Ligand)
- Structure of cgmp-unbound f403v/v407a mutant tax-4 reconstituted in lipid nanodiscs (Complex from Caenorhabditis elegans)
- Cyclic nucleotide-gated cation channel (83 kDa, Protein from Caenorhabditis elegans)