Structure of 26RFa-pyroglutamylated RFamide peptide receptor complex
Resolution: 2.73 Å
EM Method: Single-particle
Fitted PDBs: 8wz2
Q-score: 0.45
Jin S, Guo S, Xu Y, Li X, Wu C, He X, Pan B, Xin W, Zhang H, Hu W, Yin Y, Zhang T, Wu K, Yuan Q, Xu HE, Xie X, Jiang Y
Cell Discov (2024) 10 pp. 58-58 [ Pubmed: 38830850 DOI: doi:10.1038/s41421-024-00670-3 ]
- G-alpha q (41 kDa, Protein from Homo sapiens)
- Orexigenic neuropeptide qrfp (2 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Scfv16 (26 kDa, Protein from Homo sapiens)
- Structure of 26rfa-pyroglutamylated rfamide peptide receptor-g protein complex (160 kDa, Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- Pyroglutamylated rf-amide peptide receptor (49 kDa, Protein from Homo sapiens)
Structure of NET-Maprotiline in outward-open state
Resolution: 3.29 Å
EM Method: Single-particle
Fitted PDBs: 8y8z
Q-score: 0.403
Zhang H, Yin YL, Dai A, Zhang T, Zhang C, Wu C, Hu W, He X, Pan B, Jin S, Yuan Q, Wang MW, Yang D, Xu HE, Jiang Y
Nature (2024) 630 pp. 247-254 [ Pubmed: 38750358 DOI: doi:10.1038/s41586-024-07437-6 ]
- ~{n}-methyl-3-(1-tetracyclo[6.6.2.0^{2,7}.0^{9,14}]hexadeca-2(7),3,5,9,11,13-hexaenyl)propan-1-amine (277 Da, Ligand)
- Sodium ion (22 Da, Ligand)
- Sodium-dependent noradrenaline transporter (69 kDa, Protein from Homo sapiens)
- Sodium-dependent noradrenaline transporter (Complex from Homo sapiens)
- Water (18 Da, Ligand)
- Chloride ion (35 Da, Ligand)
Structure of NET-Nefopam in outward-open state
Resolution: 3.15 Å
EM Method: Single-particle
Fitted PDBs: 8y90
Q-score: 0.378
Zhang H, Yin YL, Dai A, Zhang T, Zhang C, Wu C, Hu W, He X, Pan B, Jin S, Yuan Q, Wang MW, Yang D, Xu HE, Jiang Y
Nature (2024) 630 pp. 247-254 [ Pubmed: 38750358 DOI: doi:10.1038/s41586-024-07437-6 ]
- Sodium ion (22 Da, Ligand)
- (1s)-5-methyl-1-phenyl-1,3,4,6-tetrahydro-2,5-benzoxazocine (253 Da, Ligand)
- Sodium-dependent noradrenaline transporter (69 kDa, Protein from Homo sapiens)
- Sodium-dependent noradrenaline transporter (Complex from Homo sapiens)
- Water (18 Da, Ligand)
- Chloride ion (35 Da, Ligand)
Structure of NET-nomifensine in outward-open state
Resolution: 3.13 Å
EM Method: Single-particle
Fitted PDBs: 8y91
Q-score: 0.447
Zhang H, Yin YL, Dai A, Zhang T, Zhang C, Wu C, Hu W, He X, Pan B, Jin S, Yuan Q, Wang MW, Yang D, Xu HE, Jiang Y
Nature (2024) 630 pp. 247-254 [ Pubmed: 38750358 DOI: doi:10.1038/s41586-024-07437-6 ]
- (4s)-2-methyl-4-phenyl-3,4-dihydro-1h-isoquinolin-8-amine (238 Da, Ligand)
- Sodium ion (22 Da, Ligand)
- Sodium-dependent noradrenaline transporter (69 kDa, Protein from Homo sapiens)
- Sodium-dependent noradrenaline transporter (Complex from Homo sapiens)
- Chloride ion (35 Da, Ligand)
structure of NET-Atomoxetine in outward-open state
Resolution: 3.29 Å
EM Method: Single-particle
Fitted PDBs: 8y92
Q-score: 0.42
Zhang H, Yin YL, Dai A, Zhang T, Zhang C, Wu C, Hu W, He X, Pan B, Jin S, Yuan Q, Wang MW, Yang D, Xu HE, Jiang Y
Nature (2024) 630 pp. 247-254 [ Pubmed: 38750358 DOI: doi:10.1038/s41586-024-07437-6 ]
- (3r)-n-methyl-3-(2-methylphenoxy)-3-phenyl-propan-1-amine (255 Da, Ligand)
- Sodium ion (22 Da, Ligand)
- Sodium-dependent noradrenaline transporter (69 kDa, Protein from Homo sapiens)
- Sodium-dependent noradrenaline transporter (Complex from Homo sapiens)
- Water (18 Da, Ligand)
- Chloride ion (35 Da, Ligand)
Structure of NET-Amitriptyline in outward-open state
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8y93
Q-score: 0.441
Zhang H, Yin YL, Dai A, Zhang T, Zhang C, Wu C, Hu W, He X, Pan B, Jin S, Yuan Q, Wang MW, Yang D, Xu HE, Jiang Y
Nature (2024) 630 pp. 247-254 [ Pubmed: 38750358 DOI: doi:10.1038/s41586-024-07437-6 ]
- Sodium ion (22 Da, Ligand)
- Sodium-dependent noradrenaline transporter (69 kDa, Protein from Homo sapiens)
- Sodium-dependent noradrenaline transporter (Complex from Homo sapiens)
- Amitriptyline (277 Da, Ligand)
- Chloride ion (35 Da, Ligand)
Structure of Apo human norepinephrine transporter NET
Resolution: 3.29 Å
EM Method: Single-particle
Fitted PDBs: 8y94
Q-score: 0.364
Zhang H, Yin YL, Dai A, Zhang T, Zhang C, Wu C, Hu W, He X, Pan B, Jin S, Yuan Q, Wang MW, Yang D, Xu HE, Jiang Y
Nature (2024) 630 pp. 247-254 [ Pubmed: 38750358 DOI: doi:10.1038/s41586-024-07437-6 ]
- Sodium-dependent noradrenaline transporter (69 kDa, Protein from Homo sapiens)
- Structure of apo human net (100 kDa, Complex from Homo sapiens)
Structure of NET-NE in Occluded state
Resolution: 3.24 Å
EM Method: Single-particle
Fitted PDBs: 8y95
Q-score: 0.412
Zhang H, Yin YL, Dai A, Zhang T, Zhang C, Wu C, Hu W, He X, Pan B, Jin S, Yuan Q, Wang MW, Yang D, Xu HE, Jiang Y
Nature (2024) 630 pp. 247-254 [ Pubmed: 38750358 DOI: doi:10.1038/s41586-024-07437-6 ]
- Sodium-dependent noradrenaline transporter bound noradrenaline (Complex from Homo sapiens)
- Noradrenaline (170 Da, Ligand)
- Sodium ion (22 Da, Ligand)
- Sodium-dependent noradrenaline transporter (69 kDa, Protein from Homo sapiens)
- Chloride ion (35 Da, Ligand)
Structure of NET-Nisoxetine in outward-open state
Resolution: 2.89 Å
EM Method: Single-particle
Fitted PDBs: 8yr2
Q-score: 0.47
Zhang H, Yin YL, Dai A, Zhang T, Zhang C, Wu C, Hu W, He X, Pan B, Jin S, Yuan Q, Wang MW, Yang D, Xu HE, Jiang Y
Nature (2024) 630 pp. 247-254 [ Pubmed: 38750358 DOI: doi:10.1038/s41586-024-07437-6 ]
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (746 Da, Ligand)
- Water (18 Da, Ligand)
- Nisoxetine (271 Da, Ligand)
- Sodium ion (22 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Sodium-dependent noradrenaline transporter (69 kDa, Protein from Homo sapiens)
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(2r,3r,5s,6r)-2,3,4,5,6-pentakis(oxidanyl)cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (586 Da, Ligand)
- Chloride ion (35 Da, Ligand)
- Sodium-dependent noradrenaline transporter (Complex from Homo sapiens)
Fentanyl-bound mu-opioid receptor-Gi complex
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8ef5
Q-score: 0.39
Zhuang Y, Wang Y, He B, He X, Zhou XE, Guo S, Rao Q, Yang J, Liu J, Zhou Q, Wang X, Liu M, Liu W, Jiang X, Yang D, Jiang H, Shen J, Melcher K, Chen H, Jiang Y, Cheng X, Wang MW, Xie X, Xu HE
Cell (2022) 185 pp. 4361-4375.e19 [ Pubmed: 36368306 DOI: doi:10.1016/j.cell.2022.09.041 ]
- Mu-type opioid receptor (41 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from synthetic construct)
- N-phenyl-n-[1-(2-phenylethyl)piperidin-4-yl]propanamide (336 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Rattus norvegicus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Fentanyl bound mu-opioid receptor-g protein complex (Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)