CTE type I tau filament from vacuolar tauopathy
Resolution: 2.3 Å
EM Method: Helical reconstruction
Fitted PDBs: 9erm
Q-score: 0.68
Qi C, Kobayashi R, Kawakatsu S, Kametani F, Scheres SHW, Goedert M, Hasegawa M
Acta Neuropathol (2024) 147 pp. 86-86 [ DOI: doi:10.1007/s00401-024-02741-x Pubmed: 38758288 ]
CTE type II tau filament from vacuolar tauopathy
Resolution: 2.5 Å
EM Method: Helical reconstruction
Fitted PDBs: 9ern
Q-score: 0.619
Qi C, Kobayashi R, Kawakatsu S, Kametani F, Scheres SHW, Goedert M, Hasegawa M
Acta Neuropathol (2024) 147 pp. 86-86 [ DOI: doi:10.1007/s00401-024-02741-x Pubmed: 38758288 ]
CTE type II tau filament from vacuolar tauopathy
Resolution: 2.9 Å
EM Method: Helical reconstruction
Fitted PDBs: 9ero
Q-score: 0.559
Qi C, Kobayashi R, Kawakatsu S, Kametani F, Scheres SHW, Goedert M, Hasegawa M
Acta Neuropathol (2024) 147 pp. 86-86 [ DOI: doi:10.1007/s00401-024-02741-x Pubmed: 38758288 ]
Resolution: 3.1 Å
EM Method: Helical reconstruction
Fitted PDBs: 8azu
Q-score: 0.549
Stern AM, Yang Y, Jin S, Yamashita K, Meunier AL, Liu W, Cai Y, Ericsson M, Liu L, Goedert M, Scheres SHW, Selkoe DJ
Neuron (2023) 111 pp. 2012- [ Pubmed: 37167969 DOI: doi:10.1016/j.neuron.2023.04.007 ]
Resolution: 2.8 Å
EM Method: Helical reconstruction
Fitted PDBs: 8ceb
Q-score: 0.595
Yang Y, Garringer HJ, Shi Y, Lovestam S, Peak-Chew S, Zhang X, Kotecha A, Bacioglu M, Koto A, Takao M, Spillantini MG, Ghetti B, Vidal R, Murzin AG, Scheres SHW, Goedert M
Acta Neuropathol (2023) 145 pp. 561-572 [ DOI: doi:10.1007/s00401-023-02550-8 Pubmed: 36847833 ]
Alpha-synuclein filament assembled in vitro with mutant (7 residues insertion) protein
Yang Y, Garringer HJ, Shi Y, Lovestam S, Peak-Chew S, Zhang X, Kotecha A, Bacioglu M, Koto A, Takao M, Spillantini MG, Ghetti B, Vidal R, Murzin AG, Scheres SHW, Goedert M
Acta Neuropathol (2023) 145 pp. 561-572 [ DOI: doi:10.1007/s00401-023-02550-8 Pubmed: 36847833 ]
WT alpha-synuclein filament assembled in vitro
Yang Y, Garringer HJ, Shi Y, Lovestam S, Peak-Chew S, Zhang X, Kotecha A, Bacioglu M, Koto A, Takao M, Spillantini MG, Ghetti B, Vidal R, Murzin AG, Scheres SHW, Goedert M
Acta Neuropathol (2023) 145 pp. 561-572 [ DOI: doi:10.1007/s00401-023-02550-8 Pubmed: 36847833 ]
Resolution: 2.7 Å
EM Method: Helical reconstruction
Fitted PDBs: 8ce7
Q-score: 0.606
Yang Y, Garringer HJ, Shi Y, Lovestam S, Peak-Chew S, Zhang X, Kotecha A, Bacioglu M, Koto A, Takao M, Spillantini MG, Ghetti B, Vidal R, Murzin AG, Scheres SHW, Goedert M
Acta Neuropathol (2023) 145 pp. 561-572 [ DOI: doi:10.1007/s00401-023-02550-8 Pubmed: 36847833 ]
Cryo-EM structure of alpha-synuclein singlet filament from Juvenile-onset synucleinopathy
Resolution: 2.0 Å
EM Method: Helical reconstruction
Fitted PDBs: 8bqv
Q-score: 0.74
Yang Y, Garringer HJ, Shi Y, Lovestam S, Peak-Chew S, Zhang X, Kotecha A, Bacioglu M, Koto A, Takao M, Spillantini MG, Ghetti B, Vidal R, Murzin AG, Scheres SHW, Goedert M
Acta Neuropathol (2023) 145 pp. 561-572 [ DOI: doi:10.1007/s00401-023-02550-8 Pubmed: 36847833 ]
- Alpha-synuclein (14 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Alpha-synuclein singlet filament extracted from the human brain with jos (Tissue from Homo sapiens)
- Unknown protein (613 Da, Protein from Homo sapiens)
Cryo-EM structure of alpha-synuclein filaments doublet from Juvenile-onset synucleinopathy
Resolution: 2.3 Å
EM Method: Helical reconstruction
Fitted PDBs: 8bqw
Q-score: 0.652
Yang Y, Garringer HJ, Shi Y, Lovestam S, Peak-Chew S, Zhang X, Kotecha A, Bacioglu M, Koto A, Takao M, Spillantini MG, Ghetti B, Vidal R, Murzin AG, Scheres SHW, Goedert M
Acta Neuropathol (2023) 145 pp. 561-572 [ DOI: doi:10.1007/s00401-023-02550-8 Pubmed: 36847833 ]
- Alpha-synuclein (14 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Unknown protein (783 Da, Protein from Homo sapiens)
- Alpha-synuclein doublet filament extracted from the human brain with jos (Tissue from Homo sapiens)