P301L tau filaments from human brain
Schweighauser M, Shi Y, Murzin AG, Garringer HJ, Vidal R, Murrell JR, Erro ME, Seelaar H, Ferrer I, van Swieten JC, Ghetti B, Scheres SHW, Goedert M
bioRxiv (2024) [ DOI: doi:10.1101/2024.08.15.608062 Pubmed: 39185206 ]
P301T type I tau filaments from human brain
Resolution: 2.26 Å
EM Method: Helical reconstruction
Fitted PDBs: 9gg1
Q-score: 0.69
Schweighauser M, Shi Y, Murzin AG, Garringer HJ, Vidal R, Murrell JR, Erro ME, Seelaar H, Ferrer I, van Swieten JC, Ghetti B, Scheres SHW, Goedert M
bioRxiv (2024) [ DOI: doi:10.1101/2024.08.15.608062 Pubmed: 39185206 ]
P301T type II tau filaments from human brain
Schweighauser M, Shi Y, Murzin AG, Garringer HJ, Vidal R, Murrell JR, Erro ME, Seelaar H, Ferrer I, van Swieten JC, Ghetti B, Scheres SHW, Goedert M
bioRxiv (2024) [ DOI: doi:10.1101/2024.08.15.608062 Pubmed: 39185206 ]
P301S Tau Filaments from the Brains of PS19 Transgenic Mouse Line
Resolution: 3.05 Å
EM Method: Helical reconstruction
Fitted PDBs: 8q92
Q-score: 0.556
Schweighauser M, Murzin AG, Macdonald J, Lavenir I, Crowther RA, Scheres SHW, Goedert M
Acta Neuropathol (2023) 11 pp. 160-160 [ Pubmed: 37798679 DOI: doi:10.1186/s40478-023-01658-y ]
- Microtubule-associated protein tau (9 kDa, Protein from Homo sapiens)
- P301s tau protein filament (ps19) (Tissue from Mus musculus)
Resolution: 2.8 Å
EM Method: Helical reconstruction
Fitted PDBs: 8bfz
Q-score: 0.621
Yang Y, Zhang W, Murzin AG, Schweighauser M, Huang M, Lovestam S, Peak-Chew SY, Saito T, Saido TC, Macdonald J, Lavenir I, Ghetti B, Graff C, Kumar A, Nordberg A, Goedert M, Scheres SHW
Acta Neuropathol (2023) 145 pp. 325-333 [ DOI: doi:10.1007/s00401-022-02533-1 Pubmed: 36611124 ]
Resolution: 1.99 Å
EM Method: Helical reconstruction
Fitted PDBs: 8bg0
Q-score: 0.743
Yang Y, Zhang W, Murzin AG, Schweighauser M, Huang M, Lovestam S, Peak-Chew SY, Saito T, Saido TC, Macdonald J, Lavenir I, Ghetti B, Graff C, Kumar A, Nordberg A, Goedert M, Scheres SHW
Acta Neuropathol (2023) 145 pp. 325-333 [ DOI: doi:10.1007/s00401-022-02533-1 Pubmed: 36611124 ]
Type I beta-amyloid 42 Filaments from Human Brain
Resolution: 2.5 Å
EM Method: Helical reconstruction
Fitted PDBs: 7q4b
Q-score: 0.688
Yang Y, Arseni D, Zhang W, Huang M, Lovestam S, Schweighauser M, Kotecha A, Murzin AG, Peak-Chew SY, Macdonald J, Lavenir I, Garringer HJ, Gelpi E, Newell KL, Kovacs GG, Vidal R, Ghetti B, Ryskeldi-Falcon B, Scheres SHW, Goedert M
Science (2022) 375 pp. 167-172 [ Pubmed: 35025654 DOI: doi:10.1126/science.abm7285 ]
- Beta-amyloid 42 filaments extracted from the human brain with alzheimer's disease (Tissue from Homo sapiens)
- Water (18 Da, Ligand)
- Amyloid-beta precursor protein (4 kDa, Protein from Homo sapiens)
- Unknown atom or ion (Ligand)
Type II beta-amyloid 42 Filaments from Human Brain
Resolution: 2.8 Å
EM Method: Helical reconstruction
Fitted PDBs: 7q4m
Q-score: 0.631
Yang Y, Arseni D, Zhang W, Huang M, Lovestam S, Schweighauser M, Kotecha A, Murzin AG, Peak-Chew SY, Macdonald J, Lavenir I, Garringer HJ, Gelpi E, Newell KL, Kovacs GG, Vidal R, Ghetti B, Ryskeldi-Falcon B, Scheres SHW, Goedert M
Science (2022) 375 pp. 167-172 [ Pubmed: 35025654 DOI: doi:10.1126/science.abm7285 ]