Ab typeII filament from Guam ALS/PDC
Resolution: 3.3 Å
EM Method: Helical reconstruction
Fitted PDBs: 8otf
Q-score: 0.564
Qi C, Verheijen BM, Kokubo Y, Shi Y, Tetter S, Murzin AG, Nakahara A, Morimoto S, Vermulst M, Sasaki R, Aronica E, Hirokawa Y, Oyanagi K, Kakita A, Ryskeldi-Falcon B, Yoshida M, Hasegawa M, Scheres SHW, Goedert M
PNAS (2023) 120 pp. e2306767120-e2306767120 [ DOI: doi:10.1073/pnas.2306767120 Pubmed: 38100415 ]
- Amyloid-beta precursor protein (87 kDa, Protein from Homo sapiens)
- Ab typeii filaments from guam als/pdc (Complex from Homo sapiens)
Resolution: 2.8 Å
EM Method: Helical reconstruction
Fitted PDBs: 8ceb
Q-score: 0.595
Yang Y, Garringer HJ, Shi Y, Lovestam S, Peak-Chew S, Zhang X, Kotecha A, Bacioglu M, Koto A, Takao M, Spillantini MG, Ghetti B, Vidal R, Murzin AG, Scheres SHW, Goedert M
Acta Neuropathol (2023) 145 pp. 561-572 [ DOI: doi:10.1007/s00401-023-02550-8 Pubmed: 36847833 ]
Resolution: 2.7 Å
EM Method: Helical reconstruction
Fitted PDBs: 8ce7
Q-score: 0.606
Yang Y, Garringer HJ, Shi Y, Lovestam S, Peak-Chew S, Zhang X, Kotecha A, Bacioglu M, Koto A, Takao M, Spillantini MG, Ghetti B, Vidal R, Murzin AG, Scheres SHW, Goedert M
Acta Neuropathol (2023) 145 pp. 561-572 [ DOI: doi:10.1007/s00401-023-02550-8 Pubmed: 36847833 ]
Resolution: 3.47 Å
EM Method: Helical reconstruction
Fitted PDBs: 7nca
Q-score: 0.559
Lovestam S, Schweighauser M, Matsubara T, Murayama S, Tomita T, Ando T, Hasegawa K, Yoshida M, Tarutani A, Hasegawa M, Goedert M, Scheres SHW
FEBS Open Bio (2021) 11 pp. 999-1013 [ DOI: doi:10.1002/2211-5463.13110 Pubmed: 33548114 ]
- Alpha-synuclein (14 kDa, Protein from Homo sapiens)
- Alpha synuclein filament (Complex from Homo sapiens)
Resolution: 3.43 Å
EM Method: Helical reconstruction
Fitted PDBs: 7ncg
Q-score: 0.494
Lovestam S, Schweighauser M, Matsubara T, Murayama S, Tomita T, Ando T, Hasegawa K, Yoshida M, Tarutani A, Hasegawa M, Goedert M, Scheres SHW
FEBS Open Bio (2021) 11 pp. 999-1013 [ DOI: doi:10.1002/2211-5463.13110 Pubmed: 33548114 ]
- Alpha-synuclein (14 kDa, Protein from Homo sapiens)
- Alpha synuclein filament (Complex from Homo sapiens)
Resolution: 3.84 Å
EM Method: Helical reconstruction
Fitted PDBs: 7nch
Q-score: 0.244
Lovestam S, Schweighauser M, Matsubara T, Murayama S, Tomita T, Ando T, Hasegawa K, Yoshida M, Tarutani A, Hasegawa M, Goedert M, Scheres SHW
FEBS Open Bio (2021) 11 pp. 999-1013 [ DOI: doi:10.1002/2211-5463.13110 Pubmed: 33548114 ]
- Alpha-synuclein (14 kDa, Protein from Homo sapiens)
- Alpha synuclein filament (Complex from Homo sapiens)
Resolution: 3.55 Å
EM Method: Helical reconstruction
Fitted PDBs: 7nci
Q-score: 0.377
Lovestam S, Schweighauser M, Matsubara T, Murayama S, Tomita T, Ando T, Hasegawa K, Yoshida M, Tarutani A, Hasegawa M, Goedert M, Scheres SHW
FEBS Open Bio (2021) 11 pp. 999-1013 [ DOI: doi:10.1002/2211-5463.13110 Pubmed: 33548114 ]
- Alpha-synuclein (14 kDa, Protein from Homo sapiens)
- Alpha synuclein filament (Complex from Homo sapiens)
Resolution: 4.23 Å
EM Method: Helical reconstruction
Fitted PDBs: 7ncj
Q-score: 0.176
Lovestam S, Schweighauser M, Matsubara T, Murayama S, Tomita T, Ando T, Hasegawa K, Yoshida M, Tarutani A, Hasegawa M, Goedert M, Scheres SHW
FEBS Open Bio (2021) 11 pp. 999-1013 [ DOI: doi:10.1002/2211-5463.13110 Pubmed: 33548114 ]
- Alpha-synuclein (14 kDa, Protein from Homo sapiens)
- Alpha synuclein filament (Complex from Homo sapiens)
Resolution: 3.18 Å
EM Method: Helical reconstruction
Fitted PDBs: 7nck
Q-score: 0.498
Lovestam S, Schweighauser M, Matsubara T, Murayama S, Tomita T, Ando T, Hasegawa K, Yoshida M, Tarutani A, Hasegawa M, Goedert M, Scheres SHW
FEBS Open Bio (2021) 11 pp. 999-1013 [ DOI: doi:10.1002/2211-5463.13110 Pubmed: 33548114 ]
- Alpha-synuclein (14 kDa, Protein from Homo sapiens)
- Alpha synuclein filament (Complex from Homo sapiens)
Resolution: 1.7 Å
EM Method: Single-particle
Fitted PDBs: 7a5v
Q-score: 0.75
Nakane T, Kotecha A, Sente A, McMullan G, Masiulis S, Brown PMGE, Grigoras IT, Malinauskaite L, Malinauskas T, Miehling J, Uchanski T, Yu L, Karia D, Pechnikova EV, de Jong E, Keizer J, Bischoff M, McCormack J, Tiemeijer P, Hardwick SW, Chirgadze DY, Murshudov G, Aricescu AR, Scheres SHW
Nature (2020) 587 pp. 152-156 [ DOI: doi:10.1038/s41586-020-2829-0 Pubmed: 33087931 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Megabody-25 (Complex from Lama glama)
- Human gaba(a)r-beta3 homopentamer (Complex from Homo sapiens)
- Histamine (111 Da, Ligand)
- Hexadecane (226 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit beta-3,gamma-aminobutyric acid receptor subunit beta-3 (45 kDa, Protein from Homo sapiens)
- Decane (142 Da, Ligand)
- N-octane (114 Da, Ligand)
- Human gaba(a)r-beta3 homopentamer in complex with megabody-25 in lipid nanodisc (485 kDa, Complex)
- Megabody mb25 (56 kDa, Protein from Lama glama)
- Water (18 Da, Ligand)
- Chloride ion (35 Da, Ligand)