In situ cryo-electron tomogram of a multi-lamellar vesicle in a NPC2-/- HeLa cell. #1
Kraus F, He Y, Swarup S, Overmyer KA, Jiang Y, Brenner J, Capitanio C, Bieber A, Jen A, Nightingale NM, Anderson BJ, Lee C, Paulo JA, Smith IR, Plitzko JM, Gygi SP, Schulman BA, Wilfling F, Coon JJ, Harper JW
Sci Adv (2025) 11 pp. eadu5787-eadu5787 [ DOI: doi:10.1126/sciadv.adu5787 Pubmed: 39841834 ]
In situ cryo-electron tomogram of a multi-lamellar vesicle in a NPC2-/- HeLa cell. #2
Kraus F, He Y, Swarup S, Overmyer KA, Jiang Y, Brenner J, Capitanio C, Bieber A, Jen A, Nightingale NM, Anderson BJ, Lee C, Paulo JA, Smith IR, Plitzko JM, Gygi SP, Schulman BA, Wilfling F, Coon JJ, Harper JW
Sci Adv (2025) 11 pp. eadu5787-eadu5787 [ DOI: doi:10.1126/sciadv.adu5787 Pubmed: 39841834 ]
Cryo-EM structure of a trapped ARIH1-diUB-CRL2-KLHDC10 complex - consensus map
Scott DC, Chittori S, Purser N, King MT, Maiwald SA, Churion K, Nourse A, Lee C, Paulo JA, Miller DJ, Elledge SJ, Harper JW, Kleiger G, Schulman BA
Nat Commun (2024) 15 pp. 9899-9899 [ DOI: doi:10.1038/s41467-024-54126-z Pubmed: 39548056 ]
- Klhdc10 (Protein from Homo sapiens)
- Elob (Protein from Homo sapiens)
- Cul2 (Protein from Homo sapiens)
- Nedd8 (Protein from Homo sapiens)
- Ub (Protein from Homo sapiens)
- Trapped arih1-diub-crl2-klhdc10 complex (270 kDa, Complex)
- Arih1 (Protein from Homo sapiens)
- Eloc (Protein from Homo sapiens)
- Rbx1 (Protein from Homo sapiens)
Focused map of Cryo-EM structure of Ubiquitin C-degron bound to KLHDC10-EloB/C
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 9d8p
Q-score: 0.522
Scott DC, Chittori S, Purser N, King MT, Maiwald SA, Churion K, Nourse A, Lee C, Paulo JA, Miller DJ, Elledge SJ, Harper JW, Kleiger G, Schulman BA
Nat Commun (2024) 15 pp. 9899-9899 [ DOI: doi:10.1038/s41467-024-54126-z Pubmed: 39548056 ]
- Elongin-c (12 kDa, Protein from Homo sapiens)
- Ubiquitin-c (8 kDa, Protein from Homo sapiens)
- Trapped arih1-diub-crl2-klhdc10 complex (Complex)
- Kelch domain-containing protein 10 (45 kDa, Protein from Homo sapiens)
- Elongin-b (13 kDa, Protein from Homo sapiens)
YPEL5-bound WDR26-CTLH E3 ligase - assembly I
Gottemukkala KV, Chrustowicz J, Sherpa D, Sepic S, Vu DT, Karayel O, Papadopoulou EC, Gross A, Schorpp K, von Gronau S, Hadian K, Murray PJ, Mann M, Schulman BA, Alpi AF
Mol Cell (2024) 84 pp. 1948-1963.e11 [ Pubmed: 38759627 DOI: doi:10.1016/j.molcel.2024.04.014 ]
- Complex of human wdr26-ctlh e3 ligase bound to ypel5 (900 kDa, Complex from Homo sapiens)
YPEL5-bound WDR26-CTLH E3 ligase - assembly II
Gottemukkala KV, Chrustowicz J, Sherpa D, Sepic S, Vu DT, Karayel O, Papadopoulou EC, Gross A, Schorpp K, von Gronau S, Hadian K, Murray PJ, Mann M, Schulman BA, Alpi AF
Mol Cell (2024) 84 pp. 1948-1963.e11 [ Pubmed: 38759627 DOI: doi:10.1016/j.molcel.2024.04.014 ]
- Complex of human wdr26-ctlh e3 ligase bound to ypel5 (900 kDa, Complex from Homo sapiens)
NMNAT1 core-bound RANBP9-TWA1-WDR26 module of WDR26-CTLH E3 ligase
Gottemukkala KV, Chrustowicz J, Sherpa D, Sepic S, Vu DT, Karayel O, Papadopoulou EC, Gross A, Schorpp K, von Gronau S, Hadian K, Murray PJ, Mann M, Schulman BA, Alpi AF
Mol Cell (2024) 84 pp. 1948-1963.e11 [ Pubmed: 38759627 DOI: doi:10.1016/j.molcel.2024.04.014 ]
NMNAT1 loop-bound RANBP9-TWA1-WDR26 module of WDR26-CTLH E3 ligase
Gottemukkala KV, Chrustowicz J, Sherpa D, Sepic S, Vu DT, Karayel O, Papadopoulou EC, Gross A, Schorpp K, von Gronau S, Hadian K, Murray PJ, Mann M, Schulman BA, Alpi AF
Mol Cell (2024) 84 pp. 1948-1963.e11 [ Pubmed: 38759627 DOI: doi:10.1016/j.molcel.2024.04.014 ]
NMNAT1-bound WDR26-CTLH E3 ligase assembly I - class 1
Gottemukkala KV, Chrustowicz J, Sherpa D, Sepic S, Vu DT, Karayel O, Papadopoulou EC, Gross A, Schorpp K, von Gronau S, Hadian K, Murray PJ, Mann M, Schulman BA, Alpi AF
Mol Cell (2024) 84 pp. 1948-1963.e11 [ Pubmed: 38759627 DOI: doi:10.1016/j.molcel.2024.04.014 ]
NMNAT1-bound WDR26-CTLH E3 ligase assembly I - class 2
Gottemukkala KV, Chrustowicz J, Sherpa D, Sepic S, Vu DT, Karayel O, Papadopoulou EC, Gross A, Schorpp K, von Gronau S, Hadian K, Murray PJ, Mann M, Schulman BA, Alpi AF
Mol Cell (2024) 84 pp. 1948-1963.e11 [ Pubmed: 38759627 DOI: doi:10.1016/j.molcel.2024.04.014 ]