Structure of CUL9-RBX1 ubiquitin E3 ligase complex - hexameric assembly
Resolution: 4.4 Å
EM Method: Single-particle
Fitted PDBs: 8q7e
Q-score: 0.301
Horn-Ghetko D, Hopf LVM, Tripathi-Giesgen I, Du J, Kostrhon S, Vu DT, Beier V, Steigenberger B, Prabu JR, Stier L, Bruss EM, Mann M, Xiong Y, Schulman BA
Nat Struct Mol Biol (2024) 31 pp. 1083-1094 [ Pubmed: 38605244 DOI: doi:10.1038/s41594-024-01257-y ]
- E3 ubiquitin-protein ligase rbx1 (12 kDa, Protein from Homo sapiens)
- Structure of cul9-rbx1 ubiquitin e3 ligase complex - hexameric assembly (Complex from Homo sapiens)
- Cullin-9 (281 kDa, Protein from Homo sapiens)
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 8q7h
Q-score: 0.39
Horn-Ghetko D, Hopf LVM, Tripathi-Giesgen I, Du J, Kostrhon S, Vu DT, Beier V, Steigenberger B, Prabu JR, Stier L, Bruss EM, Mann M, Xiong Y, Schulman BA
Nat Struct Mol Biol (2024) 31 pp. 1083-1094 [ Pubmed: 38605244 DOI: doi:10.1038/s41594-024-01257-y ]
- Zinc ion (65 Da, Ligand)
- Cullin-9 (281 kDa, Protein from Homo sapiens)
- E3 ubiquitin-protein ligase rbx1 (12 kDa, Protein from Homo sapiens)
- Structure of cul9-rbx1 ubiquitin e3 ligase complex in unneddylated and neddylated conformation - focused cullin dimer (Complex from Homo sapiens)
- Nedd8 (9 kDa, Protein from Homo sapiens)
- Unknown (12 kDa, Protein from Homo sapiens)
Horn-Ghetko D, Hopf LVM, Tripathi-Giesgen I, Du J, Kostrhon S, Vu DT, Beier V, Steigenberger B, Prabu JR, Stier L, Bruss EM, Mann M, Xiong Y, Schulman BA
Nat Struct Mol Biol (2024) 31 pp. 1083-1094 [ Pubmed: 38605244 DOI: doi:10.1038/s41594-024-01257-y ]
Horn-Ghetko D, Hopf LVM, Tripathi-Giesgen I, Du J, Kostrhon S, Vu DT, Beier V, Steigenberger B, Prabu JR, Stier L, Bruss EM, Mann M, Xiong Y, Schulman BA
Nat Struct Mol Biol (2024) 31 pp. 1083-1094 [ Pubmed: 38605244 DOI: doi:10.1038/s41594-024-01257-y ]
Structure of the hexameric CUL9-RBX1 complex with deletion of CUL9 CPH domain
Horn-Ghetko D, Hopf LVM, Tripathi-Giesgen I, Du J, Kostrhon S, Vu DT, Beier V, Steigenberger B, Prabu JR, Stier L, Bruss EM, Mann M, Xiong Y, Schulman BA
Nat Struct Mol Biol (2024) 31 pp. 1083-1094 [ Pubmed: 38605244 DOI: doi:10.1038/s41594-024-01257-y ]
Structure of the hexameric CUL9-RBX1 complex with deletion of CUL9 DOC domain
Horn-Ghetko D, Hopf LVM, Tripathi-Giesgen I, Du J, Kostrhon S, Vu DT, Beier V, Steigenberger B, Prabu JR, Stier L, Bruss EM, Mann M, Xiong Y, Schulman BA
Nat Struct Mol Biol (2024) 31 pp. 1083-1094 [ Pubmed: 38605244 DOI: doi:10.1038/s41594-024-01257-y ]
Structure of the hexameric CUL9-RBX1 complex with deletion of CUL9 ARM9 domain
Horn-Ghetko D, Hopf LVM, Tripathi-Giesgen I, Du J, Kostrhon S, Vu DT, Beier V, Steigenberger B, Prabu JR, Stier L, Bruss EM, Mann M, Xiong Y, Schulman BA
Nat Struct Mol Biol (2024) 31 pp. 1083-1094 [ Pubmed: 38605244 DOI: doi:10.1038/s41594-024-01257-y ]
Structure of the hexameric CUL9-RBX1 complex with deletion of CUL9 ARIH-RBR element
Horn-Ghetko D, Hopf LVM, Tripathi-Giesgen I, Du J, Kostrhon S, Vu DT, Beier V, Steigenberger B, Prabu JR, Stier L, Bruss EM, Mann M, Xiong Y, Schulman BA
Nat Struct Mol Biol (2024) 31 pp. 1083-1094 [ Pubmed: 38605244 DOI: doi:10.1038/s41594-024-01257-y ]
Resolution: 3.37 Å
EM Method: Single-particle
Fitted PDBs: 8rhz
Q-score: 0.425
Horn-Ghetko D, Hopf LVM, Tripathi-Giesgen I, Du J, Kostrhon S, Vu DT, Beier V, Steigenberger B, Prabu JR, Stier L, Bruss EM, Mann M, Xiong Y, Schulman BA
Nat Struct Mol Biol (2024) 31 pp. 1083-1094 [ Pubmed: 38605244 DOI: doi:10.1038/s41594-024-01257-y ]
- E3 ubiquitin-protein ligase rbx1 (12 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Cullin-9 (281 kDa, Protein from Homo sapiens)
- Structure of cul9-rbx1 ubiquitin e3 ligase complex in unneddylated conformation - symmetry expanded unneddylated dimer (Complex from Homo sapiens)
Liwocha J, Li J, Purser N, Rattanasopa C, Maiwald S, Krist DT, Scott DC, Steigenberger B, Prabu JR, Schulman BA, Kleiger G
Nat Struct Mol Biol (2024) 31 pp. 378-389 [ DOI: doi:10.1038/s41594-023-01206-1 Pubmed: 38326650 ]
- Protein fem-1 homolog c (68 kDa, Protein from Homo sapiens)
- E3 ubiquitin-protein ligase rbx1 (12 kDa, Protein from Homo sapiens)
- Elongin-c (12 kDa, Protein from Homo sapiens)
- Elongin-b (elob), elongin-c (eloc), protein fem-1 homolog c (fem1c) and trapped ube2r2-donor ub-acceptor ub-sil1 peptide (Complex from Homo sapiens)
- Polyubiquitin-c,nucleotide exchange factor sil1 (79 kDa, Protein from Homo sapiens)
- Ring e3 ligase (rbx1) and cullin-2 (cul2) (Complex from Homo sapiens)
- Cullin-2 (87 kDa, Protein from Homo sapiens)
- Elongin-b (13 kDa, Protein from Homo sapiens)
- K48-linked ubiquitin chain formation with a cullin-ring e3 ligase and cdc34:nedd8-cul2-rbx1-elob/c-fem1c with trapped ube2r2-donor ub-acceptor ub-sil1 peptide (190 kDa, Complex)