Cryo-EM structure of the g1:Ox-bound human GLP-1R-Gs complex
Resolution: 2.99 Å
EM Method: Single-particle
Fitted PDBs: 9j1p
Q-score: 0.505
Fan S, Li J, Zhuang J, Zhou Q, Mai Y, Lin B, Wang MW, Wu C
J Am Chem Soc (2025) 147 pp. 4821-4832 [ Pubmed: 39688263 DOI: doi:10.1021/jacs.4c12808 ]
- G1:ox (5 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Cryo-em structure of the g1 ox-bound human glp-1r-gs complex (Complex from Homo sapiens)
- Nanobody-35 (15 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- Glucagon-like peptide 1 receptor (50 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1,guanine nucleotide-binding protein g(s) subunit alpha isoforms short,guanine nucleotide-binding protein g(s) subunit alpha isoforms xlas (41 kDa, Protein from Homo sapiens)
Cryo-EM structure of the GLP-1(9-36)-bound human GLP-1R-Gs complex
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 9ivg
Q-score: 0.48
Li J, Li G, Mai Y, Liu X, Yang D, Zhou Q, Wang MW
Acta Pharm Sin B (2024) 14 pp. 5069-5073 [ Pubmed: 39664415 DOI: doi:10.1016/j.apsb.2024.09.002 ]
- Glp-1(9-36) (3 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Nanobody-35 (15 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1,guanine nucleotide-binding protein g(s) subunit alpha isoforms short (41 kDa, Protein from Homo sapiens)
- Glucagon-like peptide 1 receptor (50 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Cryo-em structure of the glp-1(9-36)-bound human glp-1r-gs complex (Complex from Homo sapiens)
Structure of human pyruvate carboxylase
Resolution: 2.61 Å
EM Method: Single-particle
Fitted PDBs: 8xl9
Q-score: 0.559
Zhou FY, Zhang YY, Zhu Y, Zhou Q, Shi Y, Hu Q
eLife (2024) [ DOI: doi:10.7554/eLife.98885.2 ]
- Biotin (244 Da, Ligand)
- Pyruvate carboxylase, mitochondrial (129 kDa, Protein from Homo sapiens)
- Homotetramer complex of human pyruvate carboxylase (Complex from Homo sapiens)
Cryo-EM structure of the GLP-1(9-36)-bound human GLP-1R-Gs complex in the presence of LSN3318839
Resolution: 3.22 Å
EM Method: Single-particle
Fitted PDBs: 9ivm
Q-score: 0.455
Li J, Li G, Mai Y, Liu X, Yang D, Zhou Q, Wang MW
Acta Pharm Sin B (2024) 14 pp. 5069-5073 [ Pubmed: 39664415 DOI: doi:10.1016/j.apsb.2024.09.002 ]
- Cryo-em structure of the glp-1(9-36)-bound human glp-1r-gs complex in the presence of lsn3318839 (Complex from Homo sapiens)
- Glp-1(9-36) (3 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Nanobody-35 (15 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1,guanine nucleotide-binding protein g(s) subunit alpha isoforms short (41 kDa, Protein from Homo sapiens)
- Glucagon-like peptide 1 receptor (50 kDa, Protein from Homo sapiens)
- (2~{r})-2-[2-[1-[(1~{r})-1-[2,6-bis(chloranyl)-3-cyclopropyl-phenyl]ethyl]imidazo[4,5-c]pyridin-6-yl]phenyl]propanoic acid (480 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
Structure of human propionyl-CoA carboxylase at apo-state (PCC-Apo)
Resolution: 3.02 Å
EM Method: Single-particle
Fitted PDBs: 8xl3
Q-score: 0.385
Zhou F, Zhang Y, Zhu Y, Zhou Q, Shi Y, Hu Q
eLife (2024) [ DOI: doi:10.7554/elife.98885.2 ]
- Heterododecamer complex of human propionyl-coa carboxylase at apo-state (pcc-apo) (Complex from Homo sapiens)
- Biotin (244 Da, Ligand)
- Propionyl-coa carboxylase alpha chain, mitochondrial (80 kDa, Protein from Homo sapiens)
- Propionyl-coa carboxylase beta chain, mitochondrial (58 kDa, Protein from Homo sapiens)
Structure of human propionyl-CoA carboxylase in complex with acetyl-CoA (PCC-ACO)
Resolution: 3.38 Å
EM Method: Single-particle
Fitted PDBs: 8xl4
Q-score: 0.358
Zhou F, Zhang Y, Zhu Y, Zhou Q, Shi Y, Hu Q
eLife (2024) [ DOI: doi:10.7554/elife.98885.2 ]
- Propionyl-coa carboxylase beta chain, mitochondrial (58 kDa, Protein from Homo sapiens)
- Biotin (244 Da, Ligand)
- Heterododecamer complex of human propionyl-coa carboxylase in complex with acetyl-coa (pcc-aco) (Complex from Homo sapiens)
- Acetyl coenzyme *a (809 Da, Ligand)
- Propionyl-coa carboxylase alpha chain, mitochondrial (80 kDa, Protein from Homo sapiens)
Structure of human propionyl-CoA carboxylase in complex with propionyl-CoA (PCC-PCO)
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8xl5
Q-score: 0.422
Zhou F, Zhang Y, Zhu Y, Zhou Q, Shi Y, Hu Q
eLife (2024) [ DOI: doi:10.7554/elife.98885.2 ]
- Propionyl-coa carboxylase beta chain, mitochondrial (58 kDa, Protein from Homo sapiens)
- Biotin (244 Da, Ligand)
- Heterododecamer complex of human propionyl-coa carboxylase in complex with propionyl-coa (pcc-pco) (Complex from Homo sapiens)
- Propionyl coenzyme a (823 Da, Ligand)
- Propionyl-coa carboxylase alpha chain, mitochondrial (80 kDa, Protein from Homo sapiens)
Structure of human 3-methylcrotonyl-CoA carboxylase at apo-state (MCC-Apo)
Resolution: 2.29 Å
EM Method: Single-particle
Fitted PDBs: 8xl6
Q-score: 0.531
Zhou F, Zhang Y, Zhu Y, Zhou Q, Shi Y, Hu Q
eLife (2024) [ DOI: doi:10.7554/elife.98885.2 ]
- Biotin (244 Da, Ligand)
- Methylcrotonoyl-coa carboxylase subunit alpha, mitochondrial (80 kDa, Protein from Homo sapiens)
- Heterododecamer complex of human 3-methylcrotonyl-coa carboxylase at apo-state (mcc-apo) (Complex from Homo sapiens)
- Methylcrotonoyl-coa carboxylase beta chain, mitochondrial (61 kDa, Protein from Homo sapiens)
Structure of human 3-methylcrotonyl-CoA carboxylase in complex with acetyl-CoA (MCC-ACO)
Resolution: 2.85 Å
EM Method: Single-particle
Fitted PDBs: 8xl7
Q-score: 0.469
Zhou F, Zhang Y, Zhu Y, Zhou Q, Shi Y, Hu Q
eLife (2024) [ DOI: doi:10.7554/elife.98885.2 ]
- Biotin (244 Da, Ligand)
- Acetyl coenzyme *a (809 Da, Ligand)
- Methylcrotonoyl-coa carboxylase subunit alpha, mitochondrial (80 kDa, Protein from Homo sapiens)
- Heterododecamer complex of human 3-methylcrotonyl-coa carboxylase in complex with acetyl-coa (mcc-aco) (Complex from Homo sapiens)
- Methylcrotonoyl-coa carboxylase beta chain, mitochondrial (61 kDa, Protein from Homo sapiens)
Structure of human 3-methylcrotonyl-CoA carboxylase in complex with propionyl-CoA (MCC-PCO)
Resolution: 2.36 Å
EM Method: Single-particle
Fitted PDBs: 8xl8
Q-score: 0.475
Zhou F, Zhang Y, Zhu Y, Zhou Q, Shi Y, Hu Q
eLife (2024) [ DOI: doi:10.7554/elife.98885.2 ]
- Biotin (244 Da, Ligand)
- Methylcrotonoyl-coa carboxylase beta chain, mitochondrial (61 kDa, Protein from Homo sapiens)
- Methylcrotonoyl-coa carboxylase subunit alpha, mitochondrial (80 kDa, Protein from Homo sapiens)
- Propionyl coenzyme a (823 Da, Ligand)
- Heterododecamer complex of human 3-methylcrotonyl-coa carboxylase in complex with propionyl-coa (mcc-pco) (Complex from Homo sapiens)