Cryo-EM structure of the g1:Ox-bound human GLP-1R-Gs complex
Resolution: 2.99 Å
EM Method: Single-particle
Fitted PDBs: 9j1p
Q-score: 0.505
Fan S, Li J, Zhuang J, Zhou Q, Mai Y, Lin B, Wang MW, Wu C
J Am Chem Soc (2025) 147 pp. 4821-4832 [ Pubmed: 39688263 DOI: doi:10.1021/jacs.4c12808 ]
- G1:ox (5 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Cryo-em structure of the g1 ox-bound human glp-1r-gs complex (Complex from Homo sapiens)
- Nanobody-35 (15 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- Glucagon-like peptide 1 receptor (50 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1,guanine nucleotide-binding protein g(s) subunit alpha isoforms short,guanine nucleotide-binding protein g(s) subunit alpha isoforms xlas (41 kDa, Protein from Homo sapiens)
Cryo-EM structure of the GLP-1(9-36)-bound human GLP-1R-Gs complex
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 9ivg
Q-score: 0.48
Li J, Li G, Mai Y, Liu X, Yang D, Zhou Q, Wang MW
Acta Pharm Sin B (2024) 14 pp. 5069-5073 [ Pubmed: 39664415 DOI: doi:10.1016/j.apsb.2024.09.002 ]
- Glp-1(9-36) (3 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Nanobody-35 (15 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1,guanine nucleotide-binding protein g(s) subunit alpha isoforms short (41 kDa, Protein from Homo sapiens)
- Glucagon-like peptide 1 receptor (50 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Cryo-em structure of the glp-1(9-36)-bound human glp-1r-gs complex (Complex from Homo sapiens)
Cryo-EM structure of the GLP-1(9-36)-bound human GLP-1R-Gs complex in the presence of LSN3318839
Resolution: 3.22 Å
EM Method: Single-particle
Fitted PDBs: 9ivm
Q-score: 0.455
Li J, Li G, Mai Y, Liu X, Yang D, Zhou Q, Wang MW
Acta Pharm Sin B (2024) 14 pp. 5069-5073 [ Pubmed: 39664415 DOI: doi:10.1016/j.apsb.2024.09.002 ]
- Cryo-em structure of the glp-1(9-36)-bound human glp-1r-gs complex in the presence of lsn3318839 (Complex from Homo sapiens)
- Glp-1(9-36) (3 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Nanobody-35 (15 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1,guanine nucleotide-binding protein g(s) subunit alpha isoforms short (41 kDa, Protein from Homo sapiens)
- Glucagon-like peptide 1 receptor (50 kDa, Protein from Homo sapiens)
- (2~{r})-2-[2-[1-[(1~{r})-1-[2,6-bis(chloranyl)-3-cyclopropyl-phenyl]ethyl]imidazo[4,5-c]pyridin-6-yl]phenyl]propanoic acid (480 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
Cryo-EM structure of the retatrutide-bound human GLP-1R-Gs complex
Resolution: 2.68 Å
EM Method: Single-particle
Fitted PDBs: 8yw3
Q-score: 0.514
Li W, Zhou Q, Cong Z, Yuan Q, Li W, Zhao F, Xu HE, Zhao LH, Yang D, Wang MW
Cell Discov (2024) 10 pp. 77-77 [ Pubmed: 39019866 DOI: doi:10.1038/s41421-024-00700-0 ]
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Retatrutide (3 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Glucagon-like peptide 1 receptor (50 kDa, Protein from Homo sapiens)
- Cryo-em structure of the human glucagon-like peptide-1 receptor in complex with retatrutide and g protein (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Nanobody-35 (15 kDa, Protein from synthetic construct)
Cryo-EM structure of the retatrutide-bound human GIPR-Gs complex
Resolution: 3.26 Å
EM Method: Single-particle
Fitted PDBs: 8yw4
Q-score: 0.379
Li W, Zhou Q, Cong Z, Yuan Q, Li W, Zhao F, Xu HE, Zhao LH, Yang D, Wang MW
Cell Discov (2024) 10 pp. 77-77 [ Pubmed: 39019866 DOI: doi:10.1038/s41421-024-00700-0 ]
- Retatrutide (3 kDa, Protein from Homo sapiens)
- Gastric inhibitory polypeptide receptor (65 kDa, Protein from Homo sapiens)
- Mini-gs (41 kDa, Protein from Homo sapiens)
- Cryo-em structure of the retatrutide-bound human gipr-gs complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Nanobody-35 (15 kDa, Protein from synthetic construct)
Cryo-EM structure of the retatrutide-bound human GCGR-Gs complex
Resolution: 2.84 Å
EM Method: Single-particle
Fitted PDBs: 8yw5
Q-score: 0.57
Li W, Zhou Q, Cong Z, Yuan Q, Li W, Zhao F, Xu HE, Zhao LH, Yang D, Wang MW
Cell Discov (2024) 10 pp. 77-77 [ Pubmed: 39019866 DOI: doi:10.1038/s41421-024-00700-0 ]
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Retatrutide (3 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Cryo-em structure of the retatrutide-bound human gcgr-gs complex (Complex from Homo sapiens)
- Glucagon receptor (46 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Nanobody-35 (15 kDa, Protein from synthetic construct)
The structure of HKU1-B S protein with bsAb1
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8yww
Q-score: 0.291
Sun H, Xia L, Li J, Zhang Y, Zhang G, Huang P, Wang X, Cui Y, Fang T, Fan P, Zhou Q, Chi X, Yu C
Emerg Microbes Infect (2024) 13 pp. 2373307-2373307 [ Pubmed: 38953857 DOI: doi:10.1080/22221751.2024.2373307 ]
- The structure of the bsab1-omicron ba.5 s complex (Complex from Severe acute respiratory syndrome coronavirus 2)
- H4b6 heavy chain (23 kDa, Protein from Homo sapiens)
- H4b6 light chain (23 kDa, Protein from Homo sapiens)
- The scfv of h4d12 (26 kDa, Protein from Homo sapiens)
- Spike glycoprotein (134 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
the complex structure of the H4B6 Fab with the RBD of Omicron BA.5 S protein
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8ywx
Q-score: 0.387
Sun H, Xia L, Li J, Zhang Y, Zhang G, Huang P, Wang X, Cui Y, Fang T, Fan P, Zhou Q, Chi X, Yu C
Emerg Microbes Infect (2024) 13 pp. 2373307-2373307 [ Pubmed: 38953857 DOI: doi:10.1080/22221751.2024.2373307 ]
- The complex structure of the h4b6 fab with the rbd of omicron ba.5 s protein (Complex from Homo sapiens)
- H4b6 fab's light chain (23 kDa, Protein from Homo sapiens)
- H4b6 fab's heavy chain (76 kDa, Protein from Homo sapiens)
- Spike protein s2' (124 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
Cryo-EM structure of GluN1-2A NMDAR in complex with human Fab5F6 in two fab bind conformation
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 8jiz
Q-score: 0.335
Wang H, Xie C, Deng B, Ding J, Li N, Kou Z, Jin M, He J, Wang Q, Wen H, Zhang J, Zhou Q, Chen S, Chen X, Yuan TF, Zhu S
Nat Struct Mol Biol (2024) 31 pp. 1987-1996 [ Pubmed: 39227720 DOI: doi:10.1038/s41594-024-01387-3 ]
- Fab5f6 heavy chain (27 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Fab5f6 light chain (25 kDa, Protein from Homo sapiens)
- Glutamate receptor ionotropic, nmda 1 (95 kDa, Protein from Homo sapiens)
- Cryo-em structure of glun1-2a nmdar in complex with human fab23 (Cell from Homo sapiens)
- Glutamate receptor ionotropic, nmda 2a (94 kDa, Protein from Homo sapiens)
Cryo-EM structure of GluN1-2A NMDAR in complex with human Fab5F6 in one fab bind conformation
Resolution: 4.5 Å
EM Method: Single-particle
Fitted PDBs: 8jj0
Q-score: 0.25
Wang H, Xie C, Deng B, Ding J, Li N, Kou Z, Jin M, He J, Wang Q, Wen H, Zhang J, Zhou Q, Chen S, Chen X, Yuan TF, Zhu S
Nat Struct Mol Biol (2024) 31 pp. 1987-1996 [ Pubmed: 39227720 DOI: doi:10.1038/s41594-024-01387-3 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Fab5f6 light chain (25 kDa, Protein from Homo sapiens)
- Fab5f6 heavy chain (27 kDa, Protein from Homo sapiens)
- Glutamate receptor ionotropic, nmda 1 (95 kDa, Protein from Homo sapiens)
- Cryo-em structure of glun1-2a nmdar in complex with human fab23 (Cell from Homo sapiens)
- Glutamate receptor ionotropic, nmda 2a (94 kDa, Protein from Homo sapiens)