Cryo-EM Structure of the Prostaglandin D2 Receptor 2 Coupled to G Protein
Resolution: 2.54 Å
EM Method: Single-particle
Fitted PDBs: 8xxu
Q-score: 0.432
Xu J, Xu Y, Hou L, He X, Li Y, Zhao J, Meng X, Wang JJ, Wu Y, Zhang H, Li Y, Hu W, Yuan Q, Wu K, Cheng X, Jiang Y, Xia Y, Xu HE, Wu C
PNAS (2024) 121 pp. e2403304121-e2403304121 [ DOI: doi:10.1073/pnas.2403304121 Pubmed: 39665758 ]
- Pd2r2-g protein (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Mus musculus)
- Prostaglandin d2 receptor 2 (38 kDa, Protein from Homo sapiens)
- [(2~{r})-1-hexadecanoyloxy-3-[oxidanyl-[(2~{s},3~{r},5~{r},6~{s})-2,3,4,5,6-pentakis(oxidanyl)cyclohexyl]oxy-phosphoryl]oxy-propan-2-yl] (~{z})-octadec-9-enoate (837 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
Cryo-EM Structure of the Prostaglandin D2 Receptor 2-indomethacin Coupled to G Protein
Resolution: 2.33 Å
EM Method: Single-particle
Fitted PDBs: 8xxv
Q-score: 0.479
Xu J, Xu Y, Hou L, He X, Li Y, Zhao J, Meng X, Wang JJ, Wu Y, Zhang H, Li Y, Hu W, Yuan Q, Wu K, Cheng X, Jiang Y, Xia Y, Xu HE, Wu C
PNAS (2024) 121 pp. e2403304121-e2403304121 [ DOI: doi:10.1073/pnas.2403304121 Pubmed: 39665758 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Mus musculus)
- [(2~{r})-1-hexadecanoyloxy-3-[oxidanyl-[(2~{s},3~{r},5~{r},6~{s})-2,3,4,5,6-pentakis(oxidanyl)cyclohexyl]oxy-phosphoryl]oxy-propan-2-yl] (~{z})-octadec-9-enoate (837 Da, Ligand)
- Prostaglandin d2 receptor 2 (38 kDa, Protein from Homo sapiens)
- Indomethacin (357 Da, Ligand)
- Pd2r2-indomethacin-g protein (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
Cryo-EM Structure of the Prostaglandin D2 Receptor 2-PGD2 Coupled to G Protein
Resolution: 2.82 Å
EM Method: Single-particle
Fitted PDBs: 9iyb
Q-score: 0.475
Xu J, Xu Y, Hou L, He X, Li Y, Zhao J, Meng X, Wang JJ, Wu Y, Zhang H, Li Y, Hu W, Yuan Q, Wu K, Cheng X, Jiang Y, Xia Y, Xu HE, Wu C
PNAS (2024) 121 pp. e2403304121-e2403304121 [ DOI: doi:10.1073/pnas.2403304121 Pubmed: 39665758 ]
- Prostaglandin d2 receptor 2-pgd2-g protein complex (160 kDa, Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Rattus norvegicus)
- [(2~{r})-1-hexadecanoyloxy-3-[oxidanyl-[(2~{s},3~{r},5~{r},6~{s})-2,3,4,5,6-pentakis(oxidanyl)cyclohexyl]oxy-phosphoryl]oxy-propan-2-yl] (~{z})-octadec-9-enoate (837 Da, Ligand)
- Prostaglandin d2 receptor 2 (43 kDa, Protein from Homo sapiens)
- Prostaglandin d2 (352 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
Structure of L797591-SSTR1 G protein complex
Resolution: 2.65 Å
EM Method: Single-particle
Fitted PDBs: 8xio
Q-score: 0.469
Wang Y, Xu Y, Wang Y, Zhang J, Chen L, He X, Fan W, Wu K, Hu W, Cheng X, Yang G, Xu HE, Zhuang Y, Sun S
PNAS (2024) 121 pp. e2400298121-e2400298121 [ DOI: doi:10.1073/pnas.2400298121 Pubmed: 39361640 ]
- L797591-sstr1 g protein complex (160 kDa, Complex from Homo sapiens)
- G-alpha-i (41 kDa, Protein from Homo sapiens)
- (2~{s})-~{n}-[(4~{s})-6-azanyl-2,2,4-trimethyl-hexyl]-3-naphthalen-1-yl-2-[[2-phenylethyl(2-pyridin-2-ylethyl)carbamoyl]amino]propanamide (607 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Nanobody nb35 (16 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Somatostatin receptor type 1 (42 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
Structure of Pasireotide-SSTR1 G protein complex
Resolution: 3.29 Å
EM Method: Single-particle
Fitted PDBs: 8xip
Q-score: 0.384
Wang Y, Xu Y, Wang Y, Zhang J, Chen L, He X, Fan W, Wu K, Hu W, Cheng X, Yang G, Xu HE, Zhuang Y, Sun S
PNAS (2024) 121 pp. e2400298121-e2400298121 [ DOI: doi:10.1073/pnas.2400298121 Pubmed: 39361640 ]
- 004-dtr-lys-ty5-phe-a1d5e (1 kDa, Protein from synthetic construct)
- G-alpha i (41 kDa, Protein from Homo sapiens)
- Pasireotide-sstr1 g protein complex (160 kDa, Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Nanobody nb35 (16 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Somatostatin receptor type 1 (42 kDa, Protein from Homo sapiens)
Structure of L796778-SSTR3 G protein complex
Resolution: 2.71 Å
EM Method: Single-particle
Fitted PDBs: 8xiq
Q-score: 0.462
Wang Y, Xu Y, Wang Y, Zhang J, Chen L, He X, Fan W, Wu K, Hu W, Cheng X, Yang G, Xu HE, Zhuang Y, Sun S
PNAS (2024) 121 pp. e2400298121-e2400298121 [ DOI: doi:10.1073/pnas.2400298121 Pubmed: 39361640 ]
- Structure of l796778-sstr3 g protein complex (160 kDa, Complex from Homo sapiens)
- G-alpha i (41 kDa, Protein from Homo sapiens)
- Nit-fc0-nle-a1d5b (584 Da, Protein from synthetic construct)
- Somatostatin receptor type 3 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Nanobody nb35 (16 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
Structure of pasireotide-SSTR3 G protein complex
Resolution: 2.52 Å
EM Method: Single-particle
Fitted PDBs: 8xir
Q-score: 0.501
Wang Y, Xu Y, Wang Y, Zhang J, Chen L, He X, Fan W, Wu K, Hu W, Cheng X, Yang G, Xu HE, Zhuang Y, Sun S
PNAS (2024) 121 pp. e2400298121-e2400298121 [ DOI: doi:10.1073/pnas.2400298121 Pubmed: 39361640 ]
- Pasireotide-sstr3 g protein complex (160 kDa, Complex from Homo sapiens)
- G-alpha i (41 kDa, Protein from Homo sapiens)
- Somatostatin receptor type 3 (45 kDa, Protein from Homo sapiens)
- Pasireotide (1 kDa, Protein from synthetic construct)
- Nanobody nb35 (16 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (41 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
Structure of 26RFa-pyroglutamylated RFamide peptide receptor complex
Resolution: 2.73 Å
EM Method: Single-particle
Fitted PDBs: 8wz2
Q-score: 0.45
Jin S, Guo S, Xu Y, Li X, Wu C, He X, Pan B, Xin W, Zhang H, Hu W, Yin Y, Zhang T, Wu K, Yuan Q, Xu HE, Xie X, Jiang Y
Cell Discov (2024) 10 pp. 58-58 [ Pubmed: 38830850 DOI: doi:10.1038/s41421-024-00670-3 ]
- G-alpha q (41 kDa, Protein from Homo sapiens)
- Orexigenic neuropeptide qrfp (2 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Scfv16 (26 kDa, Protein from Homo sapiens)
- Structure of 26rfa-pyroglutamylated rfamide peptide receptor-g protein complex (160 kDa, Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- Pyroglutamylated rf-amide peptide receptor (49 kDa, Protein from Homo sapiens)
Cryo-EM structure of succinate receptor SUCR1 bound to compound 31
Resolution: 2.48 Å
EM Method: Single-particle
Fitted PDBs: 8ykv
Q-score: 0.585
Li C, Liu H, Li J, He X, Zhu H, Fu W, Xu HE
Cell Res (2024) 34 pp. 594-596 [ Pubmed: 38834763 DOI: doi:10.1038/s41422-024-00984-7 ]
- Cryo-em structure of succinate receptor sucr1 bound to succinic acid (160 kDa, Complex from Homo sapiens)
- Antibody fragment scfv16 (26 kDa, Protein from synthetic construct)
- Succinate receptor 1 (38 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- (2~{s})-2-[[6-[4-(trifluoromethyloxy)phenyl]pyridin-2-yl]carbonylamino]butanedioic acid (398 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
Cryo-EM structure of succinate receptor SUCR1 bound to succinic acid
Resolution: 2.75 Å
EM Method: Single-particle
Fitted PDBs: 8ykw
Q-score: 0.553
Li C, Liu H, Li J, He X, Zhu H, Fu W, Xu HE
Cell Res (2024) 34 pp. 594-596 [ Pubmed: 38834763 DOI: doi:10.1038/s41422-024-00984-7 ]
- Succinic acid (118 Da, Ligand)
- Cryo-em structure of succinate receptor sucr1 bound to succinic acid (160 kDa, Complex from Homo sapiens)
- Antibody fragment scfv16 (26 kDa, Protein from synthetic construct)
- Succinate receptor 1 (38 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)