FSHR-Follicle stimulating hormone-compound 716340-Gs complex
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8i2g
Q-score: 0.363
Duan J, Xu P, Zhang H, Luan X, Yang J, He X, Mao C, Shen DD, Ji Y, Cheng X, Jiang H, Jiang Y, Zhang S, Zhang Y, Xu HE
Nat Commun (2023) 14 pp. 519-519 [ Pubmed: 36720854 DOI: doi:10.1038/s41467-023-36170-3 ]
- Glycoprotein hormones alpha chain (10 kDa, Protein from Homo sapiens)
- Myristic acid (228 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Palmitic acid (256 Da, Ligand)
- Chimera of guanine nucleotide-binding protein g(s) subunit alpha and guanine nucleotide-binding protein g(s) subunit alpha isoforms xlas (30 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Follitropin subunit beta (12 kDa, Protein from Homo sapiens)
- N-tert-butyl-n-ethyl-8-methoxy-9-propan-2-yloxy-1-thiophen-2-yl-5,6-dihydroimidazo[5,1-a]isoquinoline-3-carboxamide (467 Da, Ligand)
- Fshr-follicle stimulating hormone-compound 716340-gs complex (Complex from Homo sapiens)
- Nb35 (13 kDa, Protein from Lama glama)
- Follicle-stimulating hormone receptor (76 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
Follicle stimulating hormone receptor
Resolution: 6.0 Å
EM Method: Single-particle
Fitted PDBs: 8i2h
Q-score: 0.022
TSHR-thyroid stimulating hormone-Gs-ML109 complex
Resolution: 2.96 Å
EM Method: Single-particle
Fitted PDBs: 7xw5
Q-score: 0.482
Duan J, Xu P, Luan X, Ji Y, He X, Song N, Yuan Q, Jin Y, Cheng X, Jiang H, Zheng J, Zhang S, Jiang Y, Xu HE
Nature (2022) 609 pp. 854-859 [ Pubmed: 35940204 DOI: doi:10.1038/s41586-022-05173-3 ]
- Glycoprotein hormones alpha chain (10 kDa, Protein from Homo sapiens)
- Thyrotropin subunit beta (13 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Palmitic acid (256 Da, Ligand)
- Thyrotropin receptor (79 kDa, Protein from Homo sapiens)
- ~{n}-[4-[[2-methoxy-5-[(2~{s})-5-oxidanyl-4-oxidanylidene-3-(phenylmethyl)-1,2-dihydroquinazolin-2-yl]phenyl]methoxy]phenyl]ethanamide (523 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (29 kDa, Protein from Homo sapiens)
- Nanobody35 (14 kDa, Protein from Lama glama)
- Tshr-thyroid stimulating hormone-gs-ml109 complex (Complex from Homo)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
TSHR-Gs-M22 antibody-ML109 complex
Resolution: 2.78 Å
EM Method: Single-particle
Fitted PDBs: 7xw6
Q-score: 0.441
Duan J, Xu P, Luan X, Ji Y, He X, Song N, Yuan Q, Jin Y, Cheng X, Jiang H, Zheng J, Zhang S, Jiang Y, Xu HE
Nature (2022) 609 pp. 854-859 [ Pubmed: 35940204 DOI: doi:10.1038/s41586-022-05173-3 ]
- The complex was assembled by co-expression. (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Nanobody35 (14 kDa, Protein from Homo sapiens)
- M22 antibody light chain (11 kDa, Protein from Mus musculus)
- Palmitic acid (256 Da, Ligand)
- Thyrotropin receptor (79 kDa, Protein from Homo sapiens)
- ~{n}-[4-[[2-methoxy-5-[(2~{s})-5-oxidanyl-4-oxidanylidene-3-(phenylmethyl)-1,2-dihydroquinazolin-2-yl]phenyl]methoxy]phenyl]ethanamide (523 Da, Ligand)
- M22 antibody heavy chain (13 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (29 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
Resolution: 5.5 Å
EM Method: Single-particle
Fitted PDBs: 7xw7
Q-score: 0.04
Duan J, Xu P, Luan X, Ji Y, He X, Song N, Yuan Q, Jin Y, Cheng X, Jiang H, Zheng J, Zhang S, Jiang Y, Xu HE
Nature (2022) 609 pp. 854-859 [ Pubmed: 35940204 DOI: doi:10.1038/s41586-022-05173-3 ]
- K1-70 scfv (24 kDa, Protein from Homo sapiens)
- Thyrotropin receptor (79 kDa, Protein from Homo sapiens)
- Tshr-thyroid stimulating hormone-gs-ml109 complex (Complex from Homo)
luteinizing hormone/choriogonadotropin receptor(S277I)-chorionic gonadotropin-Gs complex
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 7fig
Q-score: 0.377
Duan J, Xu P, Cheng X, Mao C, Croll T, He X, Shi J, Luan X, Yin W, You E, Liu Q, Zhang S, Jiang H, Zhang Y, Jiang Y, Xu HE
Nature (2021) 598 pp. 688-692 [ DOI: doi:10.1038/s41586-021-03924-2 Pubmed: 34552239 ]
- Chorionic gonadotropin (Complex from Homo sapiens)
- Engineered guanine nucleotide-binding protein g(s) subunit alpha (41 kDa, Protein from Bos taurus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Glycoprotein hormones alpha chain (13 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Choriogonadotropin subunit beta 3 (17 kDa, Protein from Homo sapiens)
- Choriogonadotropin receptor (Complex from Homo sapiens)
- Antibody (Complex from Lama glama)
- Gs protein (Complex from Bos taurus)
- Lutropin-choriogonadotropic hormone receptor (78 kDa, Protein from Homo sapiens)
- Luteinizing hormone (Complex from Homo sapiens)
- Luteinizing hormone/choriogonadotropin receptor(s277i)-chorionic gonadotropin-gs complex (Complex)
- Camelid antibody vhh fragment nb35 (14 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Rattus norvegicus)
luteinizing hormone/choriogonadotropin receptor(S277I)-chorionic gonadotropin-Gs-Org43553 complex
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7fih
Q-score: 0.382
Duan J, Xu P, Cheng X, Mao C, Croll T, He X, Shi J, Luan X, Yin W, You E, Liu Q, Zhang S, Jiang H, Zhang Y, Jiang Y, Xu HE
Nature (2021) 598 pp. 688-692 [ DOI: doi:10.1038/s41586-021-03924-2 Pubmed: 34552239 ]
- Chorionic gonadotropin (Complex from Homo sapiens)
- 5-azanyl-n-tert-butyl-2-methylsulfanyl-4-[3-(2-morpholin-4-ylethanoylamino)phenyl]thieno[2,3-d]pyrimidine-6-carboxamide (514 Da, Ligand)
- Glycoprotein hormones alpha chain (12 kDa, Protein from Homo sapiens)
- Engineered guanine nucleotide-binding protein g(s) subunit alpha (41 kDa, Protein from Bos taurus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Choriogonadotropin subunit beta 3 (17 kDa, Protein from Homo sapiens)
- Choriogonadotropin receptor (Complex from Homo sapiens)
- Gs proteins (Complex from Bos taurus)
- Lutropin-choriogonadotropic hormone receptor (78 kDa, Protein from Homo sapiens)
- Luteinizing hormone (Complex from Homo sapiens)
- Luteinizing hormone/choriogonadotropin receptor(s277i)-chorionic gonadotropin-gs-org43553 complex (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Rattus norvegicus)
luteinizing hormone/choriogonadotropin receptor-chorionic gonadotropin-Gs complex
Resolution: 4.3 Å
EM Method: Single-particle
Fitted PDBs: 7fii
Q-score: 0.326
Duan J, Xu P, Cheng X, Mao C, Croll T, He X, Shi J, Luan X, Yin W, You E, Liu Q, Zhang S, Jiang H, Zhang Y, Jiang Y, Xu HE
Nature (2021) 598 pp. 688-692 [ DOI: doi:10.1038/s41586-021-03924-2 Pubmed: 34552239 ]
- Glycoprotein hormones alpha chain (Complex from Homo sapiens)
- Lutropin-choriogonadotropic hormone receptor (Complex from Homo sapiens)
- Choriogonadotropin subunit beta 3 (Complex from Homo sapiens)
- Engineered guanine nucleotide-binding protein g(s) subunit alpha (41 kDa, Protein from Bos taurus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Lutropin-choriogonadotropic hormone receptor (78 kDa, Protein from Homo sapiens)
- Glycoprotein hormones alpha chain (13 kDa, Protein from Homo sapiens)
- Choriogonadotropin subunit beta 3 (17 kDa, Protein from Homo sapiens)
- Gs proteins (Complex from Bos taurus)
- Luteinizing hormone/choriogonadotropin receptor-chorionic gonadotropin-gs complex (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Rattus norvegicus)
luteinizing hormone/choriogonadotropin receptor
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 7fij
Q-score: 0.247