P301L tau filaments from human brain
Schweighauser M, Shi Y, Murzin AG, Garringer HJ, Vidal R, Murrell JR, Erro ME, Seelaar H, Ferrer I, van Swieten JC, Ghetti B, Scheres SHW, Goedert M
bioRxiv (2024) [ DOI: doi:10.1101/2024.08.15.608062 Pubmed: 39185206 ]
P301T type I tau filaments from human brain
Resolution: 2.26 Å
EM Method: Helical reconstruction
Fitted PDBs: 9gg1
Q-score: 0.69
Schweighauser M, Shi Y, Murzin AG, Garringer HJ, Vidal R, Murrell JR, Erro ME, Seelaar H, Ferrer I, van Swieten JC, Ghetti B, Scheres SHW, Goedert M
bioRxiv (2024) [ DOI: doi:10.1101/2024.08.15.608062 Pubmed: 39185206 ]
P301T type II tau filaments from human brain
Schweighauser M, Shi Y, Murzin AG, Garringer HJ, Vidal R, Murrell JR, Erro ME, Seelaar H, Ferrer I, van Swieten JC, Ghetti B, Scheres SHW, Goedert M
bioRxiv (2024) [ DOI: doi:10.1101/2024.08.15.608062 Pubmed: 39185206 ]
Cryo-EM filament structure in FTLD-synuclein
Yang Y, Scheres HWS, Goedert M
To Be Published
- Alpha-synuclein filaments extracted from the human brain with multiple system atrophy (Complex from Homo sapiens)
- Alpha-synuclein (14 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
PHF type tau filament from V337M mutant
Resolution: 2.8 Å
EM Method: Helical reconstruction
Fitted PDBs: 9eo7
Q-score: 0.568
Qi C, Lovestam S, Murzin AG, Peak-Chew S, Franco C, Bogdani M, Latimer C, Murrell JR, Cullinane PW, Jaunmuktane Z, Bird TD, Ghetti B, Scheres SHW, Goedert M
bioRxiv (2024) [ Pubmed: 38746388 DOI: doi:10.1101/2024.04.29.591661 ]
- Tau filament v337m (Complex from Homo sapiens)
- Isoform tau-f of microtubule-associated protein tau (45 kDa, Protein from Homo sapiens)
PHF type tau filament from V337M mutant
Resolution: 3.3 Å
EM Method: Helical reconstruction
Fitted PDBs: 9eo9
Q-score: 0.486
Qi C, Lovestam S, Murzin AG, Peak-Chew S, Franco C, Bogdani M, Latimer C, Murrell JR, Cullinane PW, Jaunmuktane Z, Bird TD, Ghetti B, Scheres SHW, Goedert M
bioRxiv (2024) [ Pubmed: 38746388 DOI: doi:10.1101/2024.04.29.591661 ]
PHF type tau filament from V337M mutant
Resolution: 2.3 Å
EM Method: Helical reconstruction
Fitted PDBs: 9eoe
Q-score: 0.641
Qi C, Lovestam S, Murzin AG, Peak-Chew S, Franco C, Bogdani M, Latimer C, Murrell JR, Cullinane PW, Jaunmuktane Z, Bird TD, Ghetti B, Scheres SHW, Goedert M
bioRxiv (2024) [ Pubmed: 38746388 DOI: doi:10.1101/2024.04.29.591661 ]
PHF type tau filament from R406W mutant
Resolution: 3.0 Å
EM Method: Helical reconstruction
Fitted PDBs: 9eog
Q-score: 0.573
Qi C, Lovestam S, Murzin AG, Peak-Chew S, Franco C, Bogdani M, Latimer C, Murrell JR, Cullinane PW, Jaunmuktane Z, Bird TD, Ghetti B, Scheres SHW, Goedert M
bioRxiv (2024) [ Pubmed: 38746388 DOI: doi:10.1101/2024.04.29.591661 ]
- Microtubule-associated protein tau (45 kDa, Protein from Homo sapiens)
- Phf tau filament from mutant r406w (Complex from Homo sapiens)
PHF type tau filament from in vitro V337M mutant
Resolution: 2.8 Å
EM Method: Helical reconstruction
Fitted PDBs: 9eoh
Q-score: 0.572
Qi C, Lovestam S, Murzin AG, Peak-Chew S, Franco C, Bogdani M, Latimer C, Murrell JR, Cullinane PW, Jaunmuktane Z, Bird TD, Ghetti B, Scheres SHW, Goedert M
bioRxiv (2024) [ Pubmed: 38746388 DOI: doi:10.1101/2024.04.29.591661 ]
CTE typeI tau filament from Guam ALS/PDC
Resolution: 2.0 Å
EM Method: Helical reconstruction
Fitted PDBs: 8ot6
Q-score: 0.709
Qi C, Verheijen BM, Kokubo Y, Shi Y, Tetter S, Murzin AG, Nakahara A, Morimoto S, Vermulst M, Sasaki R, Aronica E, Hirokawa Y, Oyanagi K, Kakita A, Ryskeldi-Falcon B, Yoshida M, Hasegawa M, Scheres SHW, Goedert M
PNAS (2023) 120 pp. e2306767120-e2306767120 [ DOI: doi:10.1073/pnas.2306767120 Pubmed: 38100415 ]
- Microtubule-associated protein tau (45 kDa, Protein from Homo sapiens)
- Tau filaments from guam als/pdc (Complex from Homo sapiens)